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1-(2-Methoxyphenyl)piperazine hydrochloride

1-(2-Methoxyphenyl)piperazine hydrochloride structure

CAS No.: 5464-78-8

Chemical Name:: 1-(2-Methoxyphenyl)piperazine hydrochloride

Synonyms: OMPP;TIMTEC-BB SBB003293;Urapidil Impurity B;)piperazine hydrochL;LABOTEST-BB LT00159868;Urapidil Impurity 6 HCl;Natalizumab (Anti-CD49d);1,3-dimethyl-17-nitrosourea;2-MethoxyphenylPiperazineHCl;o-Methoxyphenyl Piperazine HCl

CBNumber:: CB4166128

Molecular Formula:: C11H17ClN2O

Molecular Weight:: 228.71848

MDL Number:: MFCD03540958

MOL File:: 5464-78-8.mol

MSDS File:: SDS

Last updated:2026-05-28 04:43:08

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1-(2-Methoxyphenyl)piperazine hydrochloride Properties

Melting point	217-219 °C(lit.)
Boiling point	130-133C
Density	1.106g/cm
refractive index	1,574-1,576
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in DMSO and Methanol.
form	A crystalline solid
Sensitive	Hygroscopic
BRN	4276925
InChI	InChI=1S/C11H16N2O.ClH/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13;/h2-5,12H,6-9H2,1H3;1H
InChIKey	DDMVHGULHRJOEC-UHFFFAOYSA-N
SMILES	N1(C2=CC=CC=C2OC)CCNCC1.[H]Cl
CAS DataBase Reference	5464-78-8(CAS DataBase Reference)
FDA UNII	3XQ74IHW73
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-28A

RIDADR

UN2811

WGK Germany

HazardClass

6.1

PackingGroup

III

HS Code

29335990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

REACH Registrations

Active

NFPA 704


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1-(2-Methoxyphenyl)piperazine hydrochloride price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	270067	1-(2-Methoxyphenyl)piperazine hydrochloride 97%	5464-78-8	100g	$171	2026-04-30	Buy
TCI Chemical	M3643	1-(2-Methoxyphenyl)piperazine Hydrochloride	5464-78-8	5G	$25	2026-04-30	Buy
TCI Chemical	M3643	1-(2-Methoxyphenyl)piperazine Hydrochloride	5464-78-8	25G	$82	2026-04-30	Buy
Cayman Chemical	37139	1-(2-Methoxyphenyl)piperazine (hydrochloride) ≥98%	5464-78-8	1mg	$49	2026-04-30	Buy
Cayman Chemical	37139	1-(2-Methoxyphenyl)piperazine (hydrochloride) ≥98%	5464-78-8	5mg	$120	2026-04-30	Buy

Product number	Packaging	Price	Buy
270067	100g	$171	Buy
M3643	5G	$25	Buy
M3643	25G	$82	Buy
37139	1mg	$49	Buy
37139	5mg	$120	Buy

1-(2-Methoxyphenyl)piperazine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

1-(2-Methoxyphenyl)piperazine hydrochloride is Off-White Solid

Uses

1-(2-Methoxyphenyl)piperazine hydrochloride is used as reference material for forensic laboratories. It is used in chemical synthesis studies.

Synthesis

tert-butyl 4-(2-methoxyphenyl)piperazine-1-carboxylate

95520-98-2

1-(2-Methoxyphenyl)piperazine hydrochloride

5464-78-8

Procedure for the synthesis of compound 6: In a double necked round bottom flask (RB flask), tert-butyl 4-(2-methoxyphenyl)piperazine-1-carboxylate (Compound 5, 0.600 g, 0.00205 mol, 1 equiv.) was dissolved in ethyl ether (10 mL) followed by addition of ethyl ether hydrochloric acid solution. The reaction mixture was stirred at room temperature overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw material, the ether was removed by evaporation under reduced pressure to give a solid product. The solid product was washed with ethyl acetate and then dried to give the final 1-(2-methoxyphenyl)piperazine hydrochloride (compound 6) as a white solid (0.425 g, 90.08% yield).

References

[1] Patent: US2010/331307, 2010, A1. Location in patent: Page/Page column 19
[2] Patent: WO2011/72174, 2011, A1. Location in patent: Page/Page column 100
[3] Patent: WO2012/3418, 2012, A2. Location in patent: Page/Page column 92

1-(2-Methoxyphenyl)piperazine hydrochloride synthesis

Synthesis of 1-(2-Methoxyphenyl)piperazine hydrochloride from Bis(2-chloroethyl)amine hydrochloride and o-Anisidine

1-(2-Methoxyphenyl)piperazine hydrochloride Preparation Products And Raw materials

Raw materials

tert-butyl 4-(2-methoxyphenyl)piperazine-1-carboxylate Bis(2-chloroethyl)amine hydrochloride o-Anisidine 2-Bromoanisole Diethyl ether

Hydrochloric acid

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Preparation Products

1-(2-Methoxyphenyl)piperazine hydrochloride Suppliers

Global( 354)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanxi Yongjin Group Co.,Ltd	4009982989 13456132869	sales2@jinjingroup.com	China	20	56
Shijiazhuang Kunen Trading Co.,Ltd	0311-89683399 15373948596	sales@kunenchem.com	China	42	58
Shijiazhuang Feizi Chemical Technology Co. LTD	0311-85957988 18633001459	sales@feizichem.com	China	82	58
Shijiazhuang Kunxiangda Technology Co., Ltd.	0311-89683399 15373948595	sales@kunenchem.com	China	20	56
Huaian Jiamu Biotechnology Co., Ltd.	0517-83187139 18205232085	cai@jiamu-bio.com	China	2999	58
Shandong Yinsheng Pharmaceutical Technology Co., Ltd	18865947357	liguiling16888@163.com	China	32	58
NINGBO SYNTAME BIOTECH CO LTD	+86-0574-28802872 18668283131	sales@syntame.com	China	114	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84

Supplier	Advantage
Shanxi Yongjin Group Co.,Ltd	56
Shijiazhuang Kunen Trading Co.,Ltd	58
Shijiazhuang Feizi Chemical Technology Co. LTD	58
Shijiazhuang Kunxiangda Technology Co., Ltd.	56
Huaian Jiamu Biotechnology Co., Ltd.	58
Shandong Yinsheng Pharmaceutical Technology Co., Ltd	58
NINGBO SYNTAME BIOTECH CO LTD	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84

View Lastest Price from 1-(2-Methoxyphenyl)piperazine hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	1-(2-Methoxyphenyl)piperazine hydrochloride 5464-78-8	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2026-03-12	Urapidil Impurity 18(Hydrochloride) 5464-78-8		10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD
2026-03-12	Urapidil Impurity 18(Hydrochloride) 5464-78-8		10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD

1-(2-Methoxyphenyl)piperazine hydrochloride
5464-78-8
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

Urapidil Impurity 18(Hydrochloride)
5464-78-8
$0.00
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

Urapidil Impurity 18(Hydrochloride)
5464-78-8
$0.00
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

1-(2-Methoxyphenyl)piperazine hydrochloride Spectrum

1-(2-Methoxyphenyl)piperazine hydrochloride(5464-78-8)¹HNMR 1-(2-Methoxyphenyl)piperazine hydrochloride(5464-78-8)Raman 1-(2-Methoxyphenyl)piperazine hydrochloride(5464-78-8)IR

5464-78-8(1-(2-Methoxyphenyl)piperazine hydrochloride)Related Search:

3-(METHOXYMETHOXY)BENZALDEHYDE Piperazine Anisole (Trifluoromethoxy)benzene p-Anisaldehyde

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1-(3-AMinopropyl)-4-(2-Methoxyphenyl)piperazine 97% 4-(3-Hydroxypropylamino)-1,3-dimethyluracil 1,3-Propanediamine, N1-(3-chloropropyl)- O-DesMethyl Urapidil 6-[(3-chloropropyl)amino]-1,3-dimethyluracil

URAPIDIL 5-METHYL- Urapidil N-Oxide 2-Demethoxy-2-chloro urapidil

1of4

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