1,2-Diphenylhydrazine
- CAS No.
- 122-66-7
- Chemical Name:
- 1,2-Diphenylhydrazine
- Synonyms
- HYDRAZOBENZENE;NSC 3510;RCRA U-109;NCI-C01854;NCI-C-01845;1,2-Diphenyl;Hydrazobenzen;n,n’-bianiline;N,N'-Bianiline;Hydroazobenzene
- CBNumber:
- CB4172325
- Molecular Formula:
- C12H12N2
- Molecular Weight:
- 184.24
- MDL Number:
- MFCD00003012
- MOL File:
- 122-66-7.mol
| Melting point | 123-126 °C(lit.) |
|---|---|
| Boiling point | 308.2°C (rough estimate) |
| Density | 1,158 g/cm3 |
| vapor pressure | 2.6 x 10-5 mmHg at 25 °C (Mabey et al., 1982) |
| refractive index | 1.6266 (estimate) |
| storage temp. | Refrigerator |
| solubility | Soluble in ethanol (Weast, 1986). |
| pka | 3.02±0.70(Predicted) |
| form | solid |
| color | Colorless to pale yellow to orange crystals |
| Water Solubility | 221 mg/L at 25 °C (U.S. EPA, 1980a) |
| BRN | 639793 |
| Henry's Law Constant | 2.1×101 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| Stability | Stable. Incompatible with strong oxidizing agents, strong acids. |
| Major Application |
cleaning products cosmetics environmental food and beverages personal care |
| InChI | 1S/C12H12N2/c1-3-7-11(8-4-1)13-14-12-9-5-2-6-10-12/h1-10,13-14H |
| InChIKey | YBQZXXMEJHZYMB-UHFFFAOYSA-N |
| SMILES | N(Nc1ccccc1)c2ccccc2 |
| Toxicology and Carcinogenesis | Bioassay of Hydrazobenzene for Possible Carcinogenicity (CASRN 122-66-7) |
| CAS DataBase Reference | 122-66-7(CAS DataBase Reference) |
| EWG's Food Scores | 5 |
| FDA UNII | 1G3CS09TUK |
| Proposition 65 List | Hydrazobenzene (1,2-Diphenylhydrazine) |
| NIST Chemistry Reference | Hydrazine, 1,2-diphenyl-(122-66-7) |
| EPA Substance Registry System | 1,2-Diphenylhydrazine (122-66-7) |
| Toxicological Profile|ATSDR | 1,2-Diphenylhydrazine|Toxicological Profile|ATSDR |
| UNSPSC Code | 77101502 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H350-H410 |
| Precautionary statements | P501-P273-P270-P202-P201-P264-P280-P391-P308+P313-P301+P312+P330-P405 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T,N |
| Risk Statements | 45-22-50/53 |
| Safety Statements | 53-45-60-61 |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | MW2625000 |
| F | 10-23 |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29280000 |
| Storage Class | 6.1D - Non-combustible acute toxic Cat.3 toxic hazardous materials or hazardous materials causing chronic effects |
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Carc. 1B |
| Hazardous Substances Data | 122-66-7(Hazardous Substances Data) |
| Toxicity | Acute oral LD50 for rats 301 mg/kg (quoted, RTECS, 1985). |
1,2-Diphenylhydrazine price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 126721 | Hydrazobenzene | 122-66-7 | 25g | $118 | 2026-04-30 | Buy |
| Sigma-Aldrich | 442232-U | 1,2-Diphenylhydrazine analytical standard, ampule of 100?mg | 122-66-7 | 100mg | $60 | 2022-05-15 | Buy |
| TCI Chemical | H0180 | Hydrazobenzene >98.0%(HPLC) | 122-66-7 | 25g | $145 | 2026-04-30 | Buy |
| TCI Chemical | H0180 | Hydrazobenzene >98.0%(HPLC) | 122-66-7 | 100g | $567 | 2026-04-30 | Buy |
| Usbiological | 273570 | 1,2-DipHenylHydrazine, TecHnical grade, remainder mainly azobenzene Asreported | 122-66-7 | 100g | $398 | 2026-06-03 | Buy |
1,2-Diphenylhydrazine Chemical Properties, Uses, Production
Description
Diphenylhydrazine is a man-made chemical that occurs in two isomeric forms: 1,1-diphenylhydrazine and 1,2-diphenylhdrazine. Diphenylhydrazine is produced by the reduction of nitrobenzene. Little or no information is available for 1,1-diphenylhydrazine. Most toxicological and use data pertain to 1,2-diphenylhydrazine.
Chemical Properties
yellow crystalline powder
Uses
Impurity in the production of Phenylbutazone (P319570). Hydrazobenzene is a metabolic intermediate of Azobenzene Carcinogenic
Uses
Formerly used as a starting material in the production of benzidine for dyes; production of certain drugs.
Uses
Previously, 1,2-diphenylhydrazine was used for producing benzidine that was used in the synthesis of benzidine-based dyes. However, these dyes are no longer produced in the United States. The primary use of 1,2-diphenylhydrazine is in the production of the anti-inflammatory agent phenylbutazone and sulfinpyrazone, a uricosuric agent.
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 36, p. 1529, 1988 DOI: 10.1248/cpb.36.1529
Tetrahedron, 32, p. 2157, 1976 DOI: 10.1016/0040-4020(76)85128-9
General Description
Orange powder or a bright orange crystalline solid.
Air & Water Reactions
1,2-Diphenylhydrazine oxidizes in air. 1,2-Diphenylhydrazine decomposes in acid solutions. Insoluble in water.
Reactivity Profile
1,2-Diphenylhydrazine is a mild reducing agent. Incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. Interaction with perchloryl fluoride in the presence of a dilutent below 32°F has caused separation of explosive solids. Is readily oxidized by nitric acid, silver nitrate or permanganate. Is reduced under alkaline conditions .
Health Hazard
1,2-Diphenylhydrazine is a liver toxin in rodents and appears to be carcinogenic in experimental animals.
Fire Hazard
Flash point data for 1,2-Diphenylhydrazine are not available; however, 1,2-Diphenylhydrazine is probably combustible.
Potential Exposure
Tumorigen,Mutagen. 1,2-Diphenylhydrazine (DPH) is a precursor inthe manufacture of benzidine, an intermediate in the production of dyes. 1,2-Diphenylhydrazine is used in the synthesis of phenylbutazone, a potent anti-inflammatory(antiarthritic) drug. Manufacturers of dyes and pharmaceuticals are subject to occupational exposure. Groups workingin the laboratory and forensic medicine may also be subjectto 1,2-diphenylhydrazine exposure.
First aid
Skin Contact: Flood all areas of body thathave contacted the substance with water. Do not wait toremove contaminated clothing; do it under the water stream.Use soap to help assure removal. Isolate contaminatedclothing when removed to prevent contact by others. EyeContact: Remove any contact lenses at once. Flush eyeswell with copious quantities of water or normal saline for atleast 2030 min. Seek medical attention. Inhalation: Leavecontaminated area immediately; breathe fresh air. Properrespiratory protection must be supplied to any rescuers. Ifcoughing, difficult breathing, or any other symptomsdevelop, seek medical attention at once, even if symptomsdevelop many hours after exposure. Ingestion: If convulsions are not present, give a glass or two of water or milk todilute the substance. Assure that the person’s airway isunobstructed and contact a hospital or poison center imm
Carcinogenicity
Hydrazobenzene is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
Biological. When 5 and 10 mg/L of diphenylhydrazine was statically incubated in the dark at 25
°C with yeast extract and settled domestic wastewater inoculum, 80 and 72% biodegradation,
respectively, were observed after 7 d (Tabak et al., 1981).
Chemical/Physical. Wet oxidation of 1,2-diphenylhydrazine at 320 °C yielded formic and acetic
acids (Randall and Knopp, 1980). 1,2-Diphenylhydrazine will not hydrolyze (Kollig, 1993).
At influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities
were 16,000, 160, 1.5, and 0.015 mg/g, respectively (Dobbs and Cohen, 1980).
storage
Color Code—Green: General storage may be used.Prior to working with this chemical you should be trainedon its proper handling and storage. Store under nitrogenaway from oxidizers, strong acids, acid chlorides, acidanhydrides. A regulated, marked area should be establishedwhere this chemical is handled, used, or stored in compliance with OSHA Standard 1910.1045.
Shipping
The name of this material is not in the DOT listof materials for label and packaging standards. However,based on regulations, it may be classified as anEnvironmentally hazardous substances, solid, n.o.s. Thischemical requires a shipping label of “CLASS 9.” It falls inHazard Class 9 and Packing Group III.[20,21]
Purification Methods
Crystallise hydrazobenzene from hot EtOH containing a little ammonium sulfide or H2SO3 (to prevent atmospheric oxidation), preferably under N2. Dry it in a vacuum desiccator, and store it in the dark or under N2. Alternatively, crystallise it from pet ether (b 60-100o) to constant absorption spectrum. It is almost colourless but in air it turns yellow, then red with the formation of azobenzene. The hydrochloride crystallises from EtOH and has m 163-164o(dec); however, hydrazobenzene readily rearranges to benzidine in the presence of acid. The picrate crystallises from *C6H6 and has m 123o(dec). [Beilstein 15 H 123.]
Toxicity evaluation
The mechanism of action of diphenylhydrazine is not known. It is possible that some toxic effects may be attributed to its major metabolites, aniline and azobenzene, both of which are known carcinogens. Results of metabolism studies reporting aniline, benzidine, hyroxybenzidines, and aminophenols as metabolites in rats following multiple routes of administration suggest that the diphenylhydrazine metabolism may be similar to that of azobenzene and aniline. It is also possible that conversion of 1,2-diphenylhydrazine to aniline in the gastrointestinal tract may occur due to intestinal microflora and via acid hydrolysis.
Incompatibilities
Not compatible with oxidizers, strongacids, acid chlorides, acid anhydrides, and mineral acidsforming benzidine. Store under nitrogen.
1,2-Diphenylhydrazine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Lianyungang Kebyke Biotechnology Co., Ltd. | 18011665355 | 304508608@qq.com | China | 121 | 58 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
View Latest Price from 1,2-Diphenylhydrazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | Hydrazobenzene
122-66-7
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2019-09-02 | Hydrazobenzene
122-66-7
|
$7.00 | 1KG | 99% | Career Henan Chemical Co |
-
- Hydrazobenzene
122-66-7
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Hydrazobenzene
122-66-7
- $7.00
- 99%
- Career Henan Chemical Co
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