2-Thiophenecarbonyl chloride
- CAS No.
- 5271-67-0
- Chemical Name:
- 2-Thiophenecarbonyl chloride
- Synonyms
- THIOPHENE-2-CARBONYL CHLORIDE;2-THENOYL CHLORIDE;2-thiophene chloride;2-THIOPHENOYL CHLORIDE;SKL1317;INDIP-024;AKOS 92490;AKOS BBS-00003924;2-Theonyl Chloride;A-THENOYL CHLORIDE
- CBNumber:
- CB4181033
- Molecular Formula:
- C5H3ClOS
- Molecular Weight:
- 146.59
- MDL Number:
- MFCD00005428
- MOL File:
- 5271-67-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Thiophenecarbonyl chloride 97% | 288985 | 25g | $64 |
| 2-Thiophenecarbonyl chloride 97% | 288985 | 100g | $109 |
| 2-Thenoyl Chloride >99.0%(T) | T0177 | 25g | $47 |
| 2-Thenoyl Chloride >99.0%(T) | T0177 | 100g | $134 |
| Thiophene-2-carbonyl chloride | 289778 | 10g | $319 |
| More product size | |||
| Boiling point | 206-208 °C (lit.) |
|---|---|
| Density | 1.371 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 195 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform |
| form | Liquid |
| Specific Gravity | 1.371 |
| color | Clear colorless to yellow-gray |
| Sensitive | Moisture Sensitive |
| BRN | 110145 |
| InChI | 1S/C5H3ClOS/c6-5(7)4-2-1-3-8-4/h1-3H |
| InChIKey | QIQITDHWZYEEPA-UHFFFAOYSA-N |
| SMILES | ClC(=O)c1cccs1 |
| CAS DataBase Reference | 5271-67-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Thiophenecarbonyl chloride(5271-67-0) |
| EPA Substance Registry System | 2-Thiophenecarbonyl chloride (5271-67-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H290-H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P305+P351+P338+P310 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-37 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Eye Dam. 1 Met. Corr. 1 Skin Corr. 1B |
|||||||||
| REACH Registrations | Inactive | |||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
2-Thiophenecarbonyl chloride price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 288985 | 2-Thiophenecarbonyl chloride 97% | 5271-67-0 | 25g | $64 | 2026-04-30 | Buy |
| Sigma-Aldrich | 288985 | 2-Thiophenecarbonyl chloride 97% | 5271-67-0 | 100g | $109 | 2026-04-30 | Buy |
| TCI Chemical | T0177 | 2-Thenoyl Chloride >99.0%(T) | 5271-67-0 | 25g | $47 | 2026-04-30 | Buy |
| TCI Chemical | T0177 | 2-Thenoyl Chloride >99.0%(T) | 5271-67-0 | 100g | $134 | 2026-04-30 | Buy |
| Usbiological | 289778 | Thiophene-2-carbonyl chloride | 5271-67-0 | 10g | $319 | 2026-06-03 | Buy |
2-Thiophenecarbonyl chloride Chemical Properties,Uses,Production
Chemical Properties
CLEAR COLOURLESS TO YELLOW-GREY LIQUID
Uses
2-Thiophenecarbonyl Chloride is used in the synthesis of substituted pyridines as selective and highly effective GPR119 agonists. It is also seen in the preparation of diuretics.
Uses
2-Thiophenecarbonyl chloride was used in the synthesis of building blocks derived from ornithine by undergoing acylation/sulphonation of copper complex of orthinine.
General Description
The postfunctionalization reaction of 2-thiophenecarbonyl chloride with single walled carbon nanotubes (SWCNTs) was studied.
Synthesis
88-15-3
5271-67-0
The general procedure for the synthesis of 2-thiophenecarbonyl chloride from 2-acetylthiophene was as follows: to a mixed solution containing 2-acetylthiophene (0.108 mL, 1.0 mmol), pyridine (0.016 mL, 0.20 mmol), and chlorobenzene (0.35 mL), disulfur dichloride (S2Cl2, 0.16 mL, 2.0 mmol) was slowly added at room temperature (S2Cl2, 0.16 mL, 2.0 mmol), while stirring continuously. After the reaction mixture was stirred for 1 hour and 45 minutes, sulfuryl chloride (SO2Cl2, 0.162 mL, 2.0 mmol) was added dropwise, followed by continued stirring for 0.5 hours at room temperature. Next, the reaction mixture was heated to 132 °C and stirred at this temperature for 14 hours. Upon completion of the reaction, the reaction mixture was diluted with deuterated chloroform (CDCl3, 2 mL) and the internal standard (tributyl phosphate, 1BU3PO4, 0.0552 mL, 0.20 mmol) was added for nuclear magnetic resonance (1H NMR) analysis. The analytical results showed that the yield of 2-thiophenecarbonyl chloride was 90%.
References
[1] Patent: WO2017/5606, 2017, A1. Location in patent: Page/Page column 31-32
[2] Journal of Organic Chemistry, 2015, vol. 80, # 20, p. 10370 - 10374
[3] Patent: WO2016/150937, 2016, A1. Location in patent: Page/Page column 27
[4] Patent: WO2016/202757, 2016, A1. Location in patent: Page/Page column 30; 31
[5] Patent: TW2017/36360, 2017, A
2-Thiophenecarbonyl chloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Jiuwu Chemical co., Ltd. | +86-0519-85121086 +8613775162768 | info@jiuwuchem.cn | China | 77 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | FandaChem@Gmail.com | China | 1445 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
View Lastest Price from 2-Thiophenecarbonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-09 | 2-Thenoyl Chloride
5271-67-0
|
$9.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-12-24 | 2-Thiophenecarbonyl chloride
5271-67-0
|
$89.00 | 1KG | 99% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-06-27 | 2-Thiophenecarbonyl chloride
5271-67-0
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 2-Thenoyl Chloride
5271-67-0
- $9.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Thiophenecarbonyl chloride
5271-67-0
- $89.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Thiophenecarbonyl chloride
5271-67-0
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
