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2-Thiophenecarbonyl chloride

2-Thiophenecarbonyl chloride Structure
2-Thiophenecarbonyl chloride structure
CAS No.
5271-67-0
Chemical Name:
2-Thiophenecarbonyl chloride
Synonyms
THIOPHENE-2-CARBONYL CHLORIDE;2-THENOYL CHLORIDE;2-thiophene chloride;2-THIOPHENOYL CHLORIDE;SKL1317;INDIP-024;AKOS 92490;AKOS BBS-00003924;2-Theonyl Chloride;A-THENOYL CHLORIDE
CBNumber:
CB4181033
Molecular Formula:
C5H3ClOS
Molecular Weight:
146.59
MDL Number:
MFCD00005428
MOL File:
5271-67-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:18:39
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2-Thiophenecarbonyl chloride Properties

Boiling point 206-208 °C (lit.)
Density 1.371 g/mL at 25 °C (lit.)
refractive index n20/D 1.590(lit.)
Flash point 195 °F
storage temp. 2-8°C
solubility Chloroform
form Liquid
Specific Gravity 1.371
color Clear colorless to yellow-gray
Sensitive Moisture Sensitive
BRN 110145
InChI 1S/C5H3ClOS/c6-5(7)4-2-1-3-8-4/h1-3H
InChIKey QIQITDHWZYEEPA-UHFFFAOYSA-N
SMILES ClC(=O)c1cccs1
CAS DataBase Reference 5271-67-0(CAS DataBase Reference)
NIST Chemistry Reference 2-Thiophenecarbonyl chloride(5271-67-0)
EPA Substance Registry System 2-Thiophenecarbonyl chloride (5271-67-0)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H290-H314
Precautionary statements  P280-P303+P361+P353-P305+P351+P338+P310
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  C
Risk Statements  34-37
Safety Statements  26-36/37/39-45
RIDADR  UN 3265 8/PG 2
WGK Germany  3
F  8
TSCA  TSCA listed
HazardClass  8
PackingGroup  II
HS Code  29349990
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Eye Dam. 1
Met. Corr. 1
Skin Corr. 1B
REACH Registrations Inactive
Limited Quantities 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
2
3 1

2-Thiophenecarbonyl chloride price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 288985 2-Thiophenecarbonyl chloride 97% 5271-67-0 25g $64 2026-04-30 Buy
Sigma-Aldrich 288985 2-Thiophenecarbonyl chloride 97% 5271-67-0 100g $109 2026-04-30 Buy
TCI Chemical T0177 2-Thenoyl Chloride >99.0%(T) 5271-67-0 25g $47 2026-04-30 Buy
TCI Chemical T0177 2-Thenoyl Chloride >99.0%(T) 5271-67-0 100g $134 2026-04-30 Buy
Usbiological 289778 Thiophene-2-carbonyl chloride 5271-67-0 10g $319 2026-06-03 Buy
Product number Packaging Price Buy
288985 25g $64 Buy
288985 100g $109 Buy
T0177 25g $47 Buy
T0177 100g $134 Buy
289778 10g $319 Buy

2-Thiophenecarbonyl chloride Chemical Properties, Uses, Production

Chemical Properties

CLEAR COLOURLESS TO YELLOW-GREY LIQUID

Uses

2-Thiophenecarbonyl Chloride is used in the synthesis of substituted pyridines as selective and highly effective GPR119 agonists. It is also seen in the preparation of diuretics.

Uses

2-Thiophenecarbonyl chloride was used in the synthesis of building blocks derived from ornithine by undergoing acylation/sulphonation of copper complex of orthinine.

General Description

The postfunctionalization reaction of 2-thiophenecarbonyl chloride with single walled carbon nanotubes (SWCNTs) was studied.

Synthesis

2-Acetylthiophene

88-15-3

2-Thiophenecarbonyl chloride

5271-67-0

The general procedure for the synthesis of 2-thiophenecarbonyl chloride from 2-acetylthiophene was as follows: to a mixed solution containing 2-acetylthiophene (0.108 mL, 1.0 mmol), pyridine (0.016 mL, 0.20 mmol), and chlorobenzene (0.35 mL), disulfur dichloride (S2Cl2, 0.16 mL, 2.0 mmol) was slowly added at room temperature (S2Cl2, 0.16 mL, 2.0 mmol), while stirring continuously. After the reaction mixture was stirred for 1 hour and 45 minutes, sulfuryl chloride (SO2Cl2, 0.162 mL, 2.0 mmol) was added dropwise, followed by continued stirring for 0.5 hours at room temperature. Next, the reaction mixture was heated to 132 °C and stirred at this temperature for 14 hours. Upon completion of the reaction, the reaction mixture was diluted with deuterated chloroform (CDCl3, 2 mL) and the internal standard (tributyl phosphate, 1BU3PO4, 0.0552 mL, 0.20 mmol) was added for nuclear magnetic resonance (1H NMR) analysis. The analytical results showed that the yield of 2-thiophenecarbonyl chloride was 90%.

References

[1] Patent: WO2017/5606, 2017, A1. Location in patent: Page/Page column 31-32
[2] Journal of Organic Chemistry, 2015, vol. 80, # 20, p. 10370 - 10374
[3] Patent: WO2016/150937, 2016, A1. Location in patent: Page/Page column 27
[4] Patent: WO2016/202757, 2016, A1. Location in patent: Page/Page column 30; 31
[5] Patent: TW2017/36360, 2017, A

2-Thiophenecarbonyl chloride synthesis

527-72-0
5271-67-0
Synthesis of 2-Thiophenecarbonyl chloride from 2-Thiophenecarboxylic acid

2-Thiophenecarbonyl chloride Preparation Products And Raw materials

Raw materials

2-Acetylthiophene 2-Thiophenecarboxylic acid Thiophene(SIV) (9CI) Oxalyl chloride Sulfuryl chloride
4-Iodobenzoyl chloride Disulfur dichloride Pyridine 2-Iodothiophene Terephthaloyl chloride

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Preparation Products

Ethyl 2-[(2-thienylcarbonyl)amino]acetate 2-Thienyl isocyanate Thiophene-2-carboxylic acid fluoride 2-n-Butyrylthiophene tioxazafen
2-Benzoylthiophene Bis(2-thienyl) ketone 2-(Trifluoroacetyl)thiophene 6,7-Dimethoxy-2-(2-thienyl)-4H-3,1-benzoxazin-4-one ethyl 2-(thiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

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2-Thiophenecarbonyl chloride Suppliers

Global Suppliers ( 323)
Supplier Tel Email Country ProdList Advantage
Weifang Siyuan Chemical Co., Ltd. 0536-8888106 17663601818 2354379876@qq.com China 244 58
Henan Junyuejian Biotechnology Co., LTD 1555-0142250 18661514130 1035729108@qq.com China 620 58
Changzhou Jiuwu Chemical co., Ltd. 13775162768 16356194@qq.com China 28 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Supplier Advantage
Weifang Siyuan Chemical Co., Ltd. 58
Henan Junyuejian Biotechnology Co., LTD 58
Changzhou Jiuwu Chemical co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60

View Latest Price from 2-Thiophenecarbonyl chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Thenoyl Chloride pictures 2026-09-02 2-Thenoyl Chloride
5271-67-0
 $9.00 1KG 99% Henan Fengda Chemical Co., Ltd
2-Thiophenecarbonyl chloride pictures 2025-12-24 2-Thiophenecarbonyl chloride
5271-67-0
 $89.00 1KG 99% 1000 tons Shaanxi Dideu Medichem Co. Ltd
2-Thiophenecarbonyl chloride pictures 2025-06-27 2-Thiophenecarbonyl chloride
5271-67-0
 1KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd

2-Thiophenecarbonyl chloride Spectrum

2-Thiophenecarbonyl chloride(5271-67-0)MS2-Thiophenecarbonyl chloride(5271-67-0)13CNMR2-Thiophenecarbonyl chloride(5271-67-0)IR12-Thiophenecarbonyl chloride(5271-67-0)Raman

5271-67-0 (2-Thiophenecarbonyl chloride) Related Search:

Ferric chloride 2-Fluorobenzoyl chloride 2-Thiophenecarboxylic acid Sulfuryl chloride Thiophene
Choline chloride 4-tert-Butylbenzoyl chloride p-Toluoyl chloride Sodium chloride 4-Chlorobenzoyl chloride
Benzoyl chloride Calcium chloride Methanesulfonyl chloride Ammonium chloride Potassium chloride
Polyvinyl chloride Carbonyl sulfide Pyrazophos

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AKOS 92490 AKOS BBS-00003924 ALPHA-THENOYL CHLORIDE THIOPHENE-2-CARBOXYLIC ACID CHLORIDE TIMTEC-BB SBB004099 2-Thiophenzoyl Chloride 2-thienylcarbonyl chloride 2-Thiophenecarboxylic acid chloride Thiophene-2-carbonylchloride,98% Thiophene-2-carbonyl chlo 2-THIOPHENECARBONYL CHLORIDE 98% 2-Theonyl Chloride 2-(Chloroformyl)thiophene 2-Thiopheneformyl chloride 2-Thiophenecarbonyl chloride,98% 2-Thiophenecarbonyl chloride (6CI,7CI,8CI,9CI) 2-Thiophenecarbonyl 2-thiophene chloride 2-Thiophenecarbonyl chloride, 98% 25ML THIOPHENE-2-CARBOXYLIC ACID CHLORIDE FOR Rivaroxaban Impurity 112 2-THIOPHENOYL CHLORIDE 2-THIOPHENE CARBOXYL CHLORIDE 2-THIOPHENECARBONYL CHLORIDE 2-THIENOYL CHLORIDE INDIP-024 2-(Chlorocarbonyl)thiophene 2-thiophenecarbonyl chloride:thiophene-2-carbonyl chloride Thiophene-2-carboxylic acid chloride for synthesis A-THENOYL CHLORIDE 2-Thienylcarbonylchlorid Thiophene-2-carbonyL Rivaroxaban related impurities 2 2-Thenoyl Chloride > Thiophene-2-carbonyl chloride, 98%, for synthesis 2-Thiophenecarbonyl chloride ISO 9001：2015 REACH Rivaroxaban Impurity 129 SKL1317 2-Thiophenecarbonyl chloride (6CI, 7CI, 8CI, 9CI, ACI) 2-THENOYL CHLORIDE THIOPHENE-2-CARBONYL CHLORIDE 5271-67-0 2527-69-5 C7H5ClS C5ClH3OS Building Blocks Heterocyclic Building Blocks Thiophenes Building Blocks C4 to C6 Chemical Synthesis Heterocyclic Building Blocks Thiophenes ACIDHALIDE Thiophene&Benzothiophene Heterocyclic Compounds