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2-Fluorobenzoyl chloride

2-Fluorobenzoyl chloride Structure
2-Fluorobenzoyl chloride structure
CAS No.
393-52-2
Chemical Name:
2-Fluorobenzoyl chloride
Synonyms
O-FLUOROBENZOYL CHLORIDE;SKL751;NSC 88304;uorobenzoyL;2-Fluorobenzoyl;o-Fluorobenzoyl;AKOS BBS-00003920;Ataluren impurity D;2-Fluorobenzoyl chlo;2-Fluorbenzoylchlorid
CBNumber:
CB2482497
Molecular Formula:
C7H4ClFO
Molecular Weight:
158.56
MDL Number:
MFCD00000656
MOL File:
393-52-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-24 13:15:37
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2-Fluorobenzoyl chloride Properties

Melting point 4 °C (lit.)
Boiling point 90-92 °C/15 mmHg (lit.)
Density 1.328 g/mL at 25 °C (lit.)
refractive index n20/D 1.536(lit.)
Flash point 180 °F
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly)
form Liquid
Specific Gravity 1.328
color Clear colorless to faintly colored
Water Solubility Decomposition
Sensitive Lachrymatory
BRN 636864
InChI 1S/C7H4ClFO/c8-7(10)5-3-1-2-4-6(5)9/h1-4H
InChIKey RAAGZOYMEQDCTD-UHFFFAOYSA-N
SMILES Fc1ccccc1C(Cl)=O
CAS DataBase Reference 393-52-2(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII Z4H017N76S
NIST Chemistry Reference Benzoyl chloride, 2-fluoro-(393-52-2)
EPA Substance Registry System o-Fluorobenzoyl chloride (393-52-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  C
Risk Statements  34-37-36/37-14
Safety Statements  26-36/37/39-45-28A-27
RIDADR  UN 3265 8/PG 2
WGK Germany  3
RTECS  DM6640000
F  10-19-21
Hazard Note  Corrosive/Lachrymatory
TSCA  TSCA listed
HazardClass  8
PackingGroup  II
HS Code  29163900
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Skin Corr. 1B
Hazardous Substances Data 393-52-2(Hazardous Substances Data)
REACH Registrations Active
Limited Quantities 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
1
3 0

2-Fluorobenzoyl chloride price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 120847 2-Fluorobenzoyl chloride 99% 393-52-2 25g $40.2 2026-04-30 Buy
Sigma-Aldrich 120847 2-Fluorobenzoyl chloride 99% 393-52-2 100g $89.3 2026-04-30 Buy
TCI Chemical F0195 2-Fluorobenzoyl Chloride >98.0%(GC)(T) 393-52-2 25g $23 2026-04-30 Buy
TCI Chemical F0195 2-Fluorobenzoyl Chloride >98.0%(GC)(T) 393-52-2 100g $46 2026-04-30 Buy
TRC TRC-F588575-5G 2-Fluorobenzoyl Chloride 393-52-2 5g $65 2026-06-03 Buy
Product number Packaging Price Buy
120847 25g $40.2 Buy
120847 100g $89.3 Buy
F0195 25g $23 Buy
F0195 100g $46 Buy
TRC-F588575-5G 5g $65 Buy

2-Fluorobenzoyl chloride Chemical Properties,Uses,Production

Chemical Properties

clear colorless to faintly colored liquid

Uses

2-Fluorobenzoyl Chloride (cas# 393-52-2) is a compound useful in organic synthesis.

Uses

2-Fluorobenzoyl chloride has been used in the preparation of 3-(N-Hydroxycarbamimidoyl)-benzoic acid methyl ester. It has been used to develop an hollow-fiber liquid phase microextraction with in situ derivatization method coupled with HPLC-UV for the determination of metformin hydrochloride in biological fluids.

General Description

Colorless liquid.

Air & Water Reactions

Decomposes in water to form HCl with generation of heat

Reactivity Profile

2-Fluorobenzoyl chloride is sensitive to moisture. Incompatible with water, alcohol, bases (including amines) and with oxidizing agents . May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Fire Hazard

2-Fluorobenzoyl chloride is combustible.

Synthesis

2-Fluorobenzoic acid

445-29-4

2-Fluorobenzoyl chloride

393-52-2

Step I Synthesis of 2-fluorobenzoyl chloride (intermediate a): 0.714 mol (100 g) of 2-fluorobenzoic acid was added to 100 mL of toluene, and the mixture was heated to 50 °C before 5.7 mol (414 mL) of sulfoxide chloride was added slowly. The reaction mixture was reacted under reflux conditions for 7 hours. Upon completion of the reaction, the excess sulfoxide chloride was removed by evaporation to give 79 g of 2-fluorobenzoyl chloride in 70% yield.

References

[1] Phosphorus, Sulfur and Silicon and Related Elements, 1996, vol. 113, # 1-4, p. 179 - 207
[2] Journal of Organometallic Chemistry, 2005, vol. 690, # 17, p. 3918 - 3928
[3] Organic and Biomolecular Chemistry, 2009, vol. 7, # 23, p. 4886 - 4894
[4] Patent: EP2799437, 2014, A1. Location in patent: Paragraph 0055
[5] Patent: US2014/364431, 2014, A1. Location in patent: Paragraph 0186

2-Fluorobenzoyl chloride Preparation Products And Raw materials

Raw materials

2-Fluorotoluene 1-(tert-butyl)-2-fluorobenzene 2-Fluorobenzoic acid Thionyl chloride Toluene

Preparation Products

2,4'-Difluorobenzophenone 2-Fluorobenzoic acid FLURAZEPAM Ataluren 2-Fluoro-N-(3,5-diMethoxyphenyl)benzaMide, 97%
2-fluorobenzoyl isothiocyanate 1-Phenyl-2-(2-fluophenyl)benzimidazole 2-Fluoro-N-[3-(trifluoroMethyl)phenyl]benzaMide, 97% 3-Methoxy-1-methyl-1H-indazole

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2-Fluorobenzoyl chloride Suppliers

Global( 501)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Qianyuan Polymer Material Co. , Ltd. 18678041314 18765609661 2547772582@qq.com China 987 58
Henan Guangwo New Materials Co., Ltd 15225201380 18336995067 3656693041@qq.com China 1820 58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 13396369453 18678026865 sdfantai@163.com China 904 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Danyang Wanlong Chemical Co., Ltd 86-511-8681 0993 jeff@wanlongchem.com China 63 55
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Shandong Qianyuan Polymer Material Co. , Ltd. 58
Henan Guangwo New Materials Co., Ltd 58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
Danyang Wanlong Chemical Co., Ltd 55
TCI (Shanghai) Development Co., Ltd. 81
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61

View Lastest Price from 2-Fluorobenzoyl chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Fluorobenzoyl chloride pictures 2026-06-30 2-Fluorobenzoyl chloride
393-52-2
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
2-Fluorobenzoyl chloride pictures 2026-06-30 2-Fluorobenzoyl chloride
393-52-2
 1KG 99.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Fluorobenzoyl Chloride pictures 2026-05-28 2-Fluorobenzoyl Chloride
393-52-2
 $10.70 10KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD

2-Fluorobenzoyl chloride Spectrum

2-Fluorobenzoyl chloride(393-52-2)MS2-Fluorobenzoyl chloride(393-52-2)1HNMR2-Fluorobenzoyl chloride(393-52-2)13CNMR2-Fluorobenzoyl chloride(393-52-2)IR12-Fluorobenzoyl chloride(393-52-2)Raman

393-52-2(2-Fluorobenzoyl chloride)Related Search:

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Sodium chloride Ammonium chloride Mepiquat chloride Benzyl chloride 3-Methylbenzoyl chloride
1-Fluoro-2-nitrobenzene Polyvinyl chloride 2-Bromobenzotrifluoride

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2-Fluorbenzoylchlorid 2-Fluorobenzoyl chlo 2-Fluorobenzoyl chloride, 97% 100ML 2-Fluorobenzoyl chloride, 97% 25ML 2-Fluorobenzenecarbonyl Chloride NSC 88304 2-Fluorobenzoyl Orthofluorine benzoyl chloride Fluorine benzoyl chloride Ataluren impurity D 2-fluoro-benzoylchlorid Benzoyl chloride, o-fluoro- uorobenzoyL Benzoylchloride,2-fluoro- o-fluoro-benzoylchlorid ortho-Fluorobenzoyl chloride o-fluorobenzenecarbonyl chloride O-FLUOROBENZOYL CHLORIDE 2-FLUOROBENZOYL CHLORIDE 2-fluoro-benzoic acid chloride AKOS BBS-00003920 o-Fluorobenzoyl 2-Fluorobenzoylchloride99% 2-Fluorbenzoesαurechlorid 2-Fluorobenzoyl Chloride o-Fluorobenzoyl Chloride 2-Fluorobenzoylchloride,97% 2-FLOUROBENZOYL CHLORIDE 2-FluorobenzoylChloride> SKL751 2-FLUOROBENZOYL CHLORIE 2-Fluorobenzoyl chloride、o-fluorobenzenecarbonyl chloride 2-Fluorobenzoyl chloride, 98% 393-52-2 Organic Building Blocks Acid Halides ACID CHLORIDE Building Blocks Carbonyl Compounds Acid Halides Aryl Fluorinated Building Blocks Building Blocks C7 Carbonyl Compounds Chemical Synthesis Fluorinated Building Blocks Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Aromatics Miscellaneous Reagents Fluorobenzene Acid Halides Carbonyl Compounds Organic Building Blocks