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2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl

2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl Structure
2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl structure
CAS No.
224311-49-3
Chemical Name:
2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl
Synonyms
tBuDavePhos;t-Butyl DavePhos;2'-(Di-tert-butylphosphino)-N,N-dimethyl-[1,1'-biphenyl]-2-amine;2'-(Di-tert-butylphosphino)-N,N-dimethyl-[1,1'-biphenyl]-2-amine;98% tBuDav;98% tBuDavePhos;t-BuDavePhos 97%;t-BuDavePhos;2-(Di-tert-butylphosphino)-2'-;2-(Di-tert-butylphosphino)-2'-(N,N-dimethylamino)b
CBNumber:
CB4192659
Molecular Formula:
C22H32NP
Molecular Weight:
341.47
MDL Number:
MFCD03426986
MOL File:
224311-49-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:06:33
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2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl Properties

Melting point 115-117 °C
Boiling point 451.6±38.0 °C(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 5.07±0.18(Predicted)
form crystal
color white
Sensitive Air Sensitive
InChI InChI=1S/C22H32NP/c1-21(2,3)24(22(4,5)6)20-16-12-10-14-18(20)17-13-9-11-15-19(17)23(7)8/h9-16H,1-8H3
InChIKey PHLPNEHPCYZBNZ-UHFFFAOYSA-N
SMILES C1(C2=CC=CC=C2P(C(C)(C)C)C(C)(C)C)=CC=CC=C1N(C)C
UNSPSC Code 12352116
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H413
Precautionary statements  P273-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26
WGK Germany  3
TSCA  No
HS Code  29319090
Storage Class 11 - Combustible Solids
Hazard Classifications Aquatic Chronic 4
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 1

2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 695874 t-BuDavePhos 97% 224311-49-3 1g $205 2026-04-30 Buy
Sigma-Aldrich 695874 t-BuDavePhos 97% 224311-49-3 5g $361.5 2026-04-30 Buy
Strem Chemicals 15-1048 2-Di-t-butylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% tBuDavePhos 98% 224311-49-3 500mg $57 2026-04-30 Buy
Strem Chemicals 15-1048 2-Di-t-butylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% tBuDavePhos 98% 224311-49-3 2g $160 2026-04-30 Buy
Strem Chemicals 15-1048 2-Di-t-butylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% tBuDavePhos 98% 224311-49-3 10g $632 2026-04-30 Buy
Product number Packaging Price Buy
695874 1g $205 Buy
695874 5g $361.5 Buy
15-1048 500mg $57 Buy
15-1048 2g $160 Buy
15-1048 10g $632 Buy

2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl Chemical Properties, Uses, Production

Reaction

  1. Useful ligand for Pd-catalyzed carbon-oxygen bond forming reactions.
  2. Ligand used selective Pd-catalyzed arylation of ammonia. Application to the synthesis of dibenzodiazepines.
  3. Ligand used for selective Pd-catalyzed silylation of aryl chlorides.
  4. Ligand used for Pd(0)-catalyzed direct dehydrative coupling of terminal alkynes with allylic alcohols to access 1,4-enynes. 
Reactions of 224311-49-3

Chemical Properties

White crystals or crystalline powder

Uses

suzuki reaction

reaction suitability

reagent type: ligand
reaction type: Arylations
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-X Bond Formation

Synthesis

The target compound 2-di-tert-butylphosphine-2-(N,N-dimethylamino)biphenyl was prepared by the Suzuki reaction using 2-bromochlorobenzene as starting material, followed by the reaction with di-tert-butylphosphonium chloride.

2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl Preparation Products And Raw materials

Raw materials

Preparation Products

Methanesulfonato2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II)

2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl Suppliers

Global Suppliers ( 231)
Supplier Tel Email Country ProdList Advantage
Xinxiang Runyu Material Co., Ltd. 166-166-37336996 15690792173 chenxi.song@runvmat.com China 282 55
Henan Research New Material Co., Ltd. 86-18903931531 18903931628 sales036@researchvip.com China 180 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Supplier Advantage
Xinxiang Runyu Material Co., Ltd. 55
Henan Research New Material Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
ShangHai DEMO Chemical Co.,Ltd 57
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Beijing Ouhe Technology Co., Ltd 60

View Latest Price from 2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Di-tert-butylphosphino-2'-(N,N-dimethylamino)biphenyl pictures 2026-09-17 2-Di-tert-butylphosphino-2'-(N,N-dimethylamino)biphenyl
224311-49-3
 50G 98%min 30KG/month WUHAN FORTUNA CHEMICAL CO., LTD
2-di-t-butylphosphino-2'-(n,n-dimethylamino)biphenyl pictures 2026-08-25 2-di-t-butylphosphino-2'-(n,n-dimethylamino)biphenyl
224311-49-3
 $2.00-5.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2-Di-tert-butylphosphino-2'-(N,N-diMethylaMino)biphenyl pictures 2026-08-07 2-Di-tert-butylphosphino-2'-(N,N-diMethylaMino)biphenyl
224311-49-3
 $1.00 1KG 99% 20 Tons Shaanxi Dideu Medichem Co. Ltd

2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl Spectrum

2-DI-T-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL(224311-49-3)1HNMR2-DI-T-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL(224311-49-3)31PNMR

224311-49-3 (2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl) Related Search:

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl CPhos 2-(Dicyclohexylphosphino)-2'-methylbiphenyl 2'-(Dicyclohexylphosphino)-N,N-dimethyl[1,1'-biphenyl]-4-amine 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl
2-Dicyclohexylphosphino-2',4',6'-triiso& 2-Diphenylphosphino-6-methylpyridine 2-Dicyclohexylphosphino-2',6'-diisopropoxybiphenyl Di-tert-butylphenylphosphine t-Butylphosphine
Di-tert-butylphosphine 2-(Di-tert-butylphosphino)biphenyl 2-DI-T-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL

1of3

2'-[Bis(1,1-dimethylethyl)phosphino]-N,N-dimethyl-[1,1'-biphenyl]-2-amine 2-Di-tert-butylphosphino-2'-(N,N-dimethylamino)biphenyl,98% 2-[2-(di-tert-butylphosphanyl)phenyl]-N,N-diMethylaniline 98% tBuDavePhos 2-(Di-tert-butylphosphiNA)-2'-(N,N-diMethylaMiNA)biphenyl 2-(Di-tert-butylphosphino)-2'- 2-Di-t-butylphosphino-2'-(N,N-diMethylaMino)biphenyl,98% tBuDavePhos t-BuDavePhos 97% 2-Di-t-butylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% 2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl, (tBuDavePhos) 2′-(Di-tert-butylphosphino)-N,N-dimethylbiphenyl-2-amine t-Butyl DavePhos 2-DI-T-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL [2'-(DI-TERT-BUTYL-PHOSPHANYL)-BIPHENYL-2-YL]-DIMETHYL-AMINE 2-DI-TERT-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL 2-DI-TERT-BUTYLPHOSHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL 2-Di-t-butylphosphino-2'-(N,N-dimethylamino)biphenyl,98% 2-Di-t-butylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% tBuDavePhos 2-(Di-tert-butylphosphino)-2'-(N,N-dimethylamino)b 98% tBuDav [1,1''-BIPHENYL]-2-AMINE, 2''-[BIS(1,1-DIMETHYLETHYL)PHOSPHINO]-N,N-DIMETHYL- 2-DI-T-BUTYLPHOSHINO-2''-(N,N-DIMETHYLAMINO)BIPHENYL 2-(2-ditert-butylphosphinophenyl)-N,N-dimethylaniline 2-Di-t-butylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl,98% 2-Di-t-butylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl 2-(Di-tert-butylphosphino)-2'-(N,N-dimethylamino)biphenyl 2'-(Di-tert-butylphosphino)-N,N-dimethylbiphenyl-2-amine 2'-[Bis(1,1-dimethylethyl)phosphino]-N,N-dimethyl[1,1'-biphenyl]-2-amine 2-Di-t-butylphosphino-2'-(N,N-diMethylaMino)biphenyl (tBuDavePhos) t-BuDavePhos 2-Di-tert-butylphosphino-2'-(N,N-dimethylamino)-1,1'-biphenyl,tBuDavePhos 2'-(Di-tert-butylphosphino)-N,N-dimethyl-[1,1'-biphenyl]-2-amine 2'-(Di-tert-butylphosphino)-N,N-dimethyl-[1,1'-biphenyl]-2-amine tBuDavePhos 224311-49-3 224311-43-3 C22H32NP CH32NC6H4C6H4PC4H92 Phosphines Achiral Phosphine Aryl Phosphine Buchwald Ligands Series Buchwald Ligands&Precatalysts