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2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl

2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl structure

CAS No.: 240417-00-9

Chemical Name:: 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl

Synonyms: PhDavePhos;PhDave-Phos 97%;2-Diphenylphosphino-2;(N,N-DIMETHYLAMINO)BIPHENYL;2-Diphenylphosphino-2'-(N,N-di;2-Diphenylphosphino-2`-dimethylaminobiphenyl;2-DIMETHYLAMINO-2'-(DIPHENYLPHOSPHINO)BIPHENYL;2-DiphenylphosphiNA-2'-(N,N-diMethylaMiNA)biphenyl;[2-(2-Dimethylaminophenyl)phenyl]diphenylphosphine;2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl

CBNumber:: CB0364760

Molecular Formula:: C26H24NP

Molecular Weight:: 381.45

MDL Number:: MFCD03094578

MOL File:: 240417-00-9.mol

MSDS File:: SDS

Last updated:2026-05-27 17:40:27

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2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl Properties

Melting point	126-128 °C
Boiling point	514.6±43.0 °C(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	4.96±0.18(Predicted)
form	Powder, Crystals, Crystalline Powder and/or Chunks
color	White to yellow
Water Solubility	insoluble
InChI	1S/C26H24NP/c1-27(2)25-19-11-9-17-23(25)24-18-10-12-20-26(24)28(21-13-5-3-6-14-21)22-15-7-4-8-16-22/h3-20H,1-2H3
InChIKey	JGFXUYLYPITYGR-UHFFFAOYSA-N
SMILES	CN(C)c1ccccc1-c2ccccc2P(c3ccccc3)c4ccccc4
CAS DataBase Reference	240417-00-9
UNSPSC Code	12352116
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

37/39-26-36/37/39

WGK Germany

TSCA

HazardClass

IRRITANT

HS Code

29310099

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	695882	PhDave-Phos 97%	240417-00-9	1g	$149	2026-04-30	Buy
Sigma-Aldrich	695882	PhDave-Phos 97%	240417-00-9	5g	$387	2023-06-20	Buy
Strem Chemicals	15-1745	2-Diphenylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% PhDavePhos 98%	240417-00-9	500mg	$36	2026-04-30	Buy
Strem Chemicals	15-1745	2-Diphenylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% PhDavePhos 98%	240417-00-9	2g	$101	2026-04-30	Buy
Strem Chemicals	15-1745	2-Diphenylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% PhDavePhos 98%	240417-00-9	10g	$400	2026-04-30	Buy

Product number	Packaging	Price	Buy
695882	1g	$149	Buy
695882	5g	$387	Buy
15-1745	500mg	$36	Buy
15-1745	2g	$101	Buy
15-1745	10g	$400	Buy

2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl Chemical Properties, Uses, Production

Reaction

Useful ligand for sterically hindered substrates in the Pd-catalyzed amination reactions of aryl bromides.
Ligand used for the Cu-catalyzed phosphorylation of alcohols.
Ligand for Pd-catalyzed C-H benzylation.
Ligand for palladium-catalyzed [4 + 2] benzannulation reaction.

Chemical Properties

white to yellow powder, crystals, crystalline

Uses

suzuki reaction

reaction suitability

reaction type: Cross Couplings
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-C Bond Formation

Synthesis

Palladium, di-μ-chlorobis[2'-(dimethylamino-κN)[1,1'-biphenyl]-2-yl-κC]di-

119326-02-2

15475-27-1

2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl

240417-00-9

The compound (CAS:119326-02-2) (29.6 mg, 0.0510 mmol) was transferred to an argon protected 10 mL Schlenk flask. The flask was evacuated and filled with argon three times to remove air. Subsequently, anhydrous THF (3.0 mL) was added using a syringe under argon atmosphere. A THF solution (0.46 mL, 0.23 mmol) of 0.5 M LiPPh2 was slowly added dropwise under stirring for a controlled time of 5 min. During the reaction, the color of the mixture changed from yellow to dark red and finally to dark yellow. The reaction mixture was stirred under argon protection at room temperature for 18 hours. After completion of the reaction, the solvent was removed using a rotary evaporator. The crude product was dissolved in dichloromethane (0.5 mL) and purified by preparative thin layer chromatography (silica gel, unfolding reagent was benzene:acetone=10:1). The final isolation afforded the target product (S)-2-diphenylphosphino-2'-(N,N-dimethylamino)biphenyl as a light yellow liquid in 46% yield (15.6 mg).

References

[1] Journal of Organometallic Chemistry, 2013, vol. 745-746, p. 356 - 362

2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl synthesis

Synthesis of 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl from 1-Bromo-2-iodobenzene

2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl Preparation Products And Raw materials

Raw materials

[1,1'-Biphenyl]-2-amine, 2'-(diphenylphosphinyl)-N,N-dimethyl- 1-Bromo-2-iodobenzene Palladium, di-μ-chlorobis[2'-(dimethylamino-κN)[1,1'-biphenyl]-2-yl-κC]di- Potassium diphenylphosphide

Preparation Products

2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl Suppliers

Global Suppliers ( 217)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Beijing VSciChem Technology Co., Ltd.	13811761079	vscichem@163.com	China	271	64
Puyang Huicheng Electronic Material Co. Ltd.	0393-0393-8910800 15039333257	info@huichengchem.com	China	588	64

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
ShangHai DEMO Chemical Co.,Ltd	57
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Beijing VSciChem Technology Co., Ltd.	64
Puyang Huicheng Electronic Material Co. Ltd.	64

View Latest Price from 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-07	2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl 240417-00-9	$1.00	1KG	99%	20 Tons	Shaanxi Dideu Medichem Co. Ltd
2026-03-20	2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl 240417-00-9		1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-23	2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl 240417-00-9		1KG	0.98	500kg	XINXIANG RUNYU MATERIAL CO., LTD.

2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl
240417-00-9
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl
240417-00-9
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl
240417-00-9
0.98
XINXIANG RUNYU MATERIAL CO., LTD.

2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl Spectrum

2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl(240417-00-9)¹HNMR 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl(240417-00-9)³¹PNMR

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Diphenylphosphine 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl

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2-DIMETHYLAMINO-2'-(DIPHENYLPHOSPHINO)BIPHENYL 2-(DIPHENYLPHOSPHINO)-2'-(N,N-DIMETHYLAMINO)BIPHENYL 2-Diphenylphosphino-2 PhDave-Phos 97% 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl,98% (N,N-DIMETHYLAMINO)BIPHENYL [1,1''-BIPHENYL]-2-AMINE, 2''-(DIPHENYLPHOSPHINO)-N,N-DIMETHYL- 2-Diphenylphosphino-2`-dimethylaminobiphenyl 2'-(Diphenylphosphino)-N,N-dimethyl-2-biphenylamine 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl,97% 2-[2-(diphenylphosphanyl)phenyl]-N,N-diMethylaniline 2-DiphenylphosphiNA-2'-(N,N-diMethylaMiNA)biphenyl 2-Diphenylphosphino-2'-(N,N-di 2-Diphenylphosphino-2'-(N,N-diMethylaMino)biphenyl PhDavePhos 2-Diphenylphosphino-2'-(N,N-diMethylaMino)biphenyl, 98% (PhDavePhos) 2′-(Diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine 2-Diphenylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% PhDavePhos 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl (This product is only available in Japan.) 2'-(diphenylphosphanyl)-N,N-dimethyl-[1,1'-biphe nyl]-2-amine [2-(2-Dimethylaminophenyl)phenyl]diphenylphosphine 2-Diphenylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl 2'-(diphenylphosphino)-N,N-dimethyl-[1,1'-biphenyl]-2-amine 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl (PhDave-Phos) 2-Diphenylphosphino-2′-(N,N-dimethylamino)biphenyl, CAS 240417-00-9 2-Diphenylphosphine-2'-[(N,N-dimethylamino)phenyl]benzene 2'-(Diphenylphosphino)-N,N-dimethyl-biphenyl-2-ylamine PhDavePhos 240417-00-9 C26H24NP Achiral Phosphine Aryl Phosphine Buchwald Ligands Series Buchwald Ligands&Precatalysts Biphenyl & Diphenyl ether Phosphines