ChemicalBook >> CAS DataBase List >>Fmoc-N-methyl-L-phenylalanine

Fmoc-N-methyl-L-phenylalanine

Fmoc-N-methyl-L-phenylalanine structure

CAS No.: 77128-73-5

Chemical Name:: Fmoc-N-methyl-L-phenylalanine

Synonyms: FMOC-N-ME-PHE-OH;(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid;FMOC-MEPHE-OH;FMOC-L-MEPHE-OH;FMOC-N-ME-L-PHE-OH;FMOC-N-ME-PHE 98.5+%;FMOC-N-ME-PHENYLALANINE;Fmoc-N-Me-Phe-OH;Fmoc-N-mety)-L-phenylalanine;FMOC-N-METHYL-L-PHENYLALANINE

CBNumber:: CB4197124

Molecular Formula:: C25H23NO4

Molecular Weight:: 401.45

MDL Number:: MFCD00151938

MOL File:: 77128-73-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:09:36

Request For Quotation

Fmoc-N-methyl-L-phenylalanine Properties

Melting point	132.0 to 136.0 °C
Boiling point	595.4±39.0 °C(Predicted)
Density	1.260±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in DMF. (0.3gram in 2ml)
pka	3.78±0.10(Predicted)
form	Powder
color	Off-white
optical activity	[α]20/D 55.0±3°, c = 1% in DMF
BRN	4768138
Major Application	peptide synthesis
InChI	InChI=1S/C25H23NO4/c1-26(23(24(27)28)15-17-9-3-2-4-10-17)25(29)30-16-22-20-13-7-5-11-18(20)19-12-6-8-14-21(19)22/h2-14,22-23H,15-16H2,1H3,(H,27,28)/t23-/m0/s1
InChIKey	GBROUWPNYVBLFO-QHCPKHFHSA-N
SMILES	C(O)(=O)[C@H](CC1=CC=CC=C1)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C
CAS DataBase Reference	77128-73-5(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H312-H332
Precautionary statements	P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P403+P233-P501
PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	22-24/25
WGK Germany	3
HS Code	2924 29 70
HazardClass	IRRITANT
Storage Class	13 - Non Combustible Solids

Fmoc-N-methyl-L-phenylalanine price More Price(77)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.52137	Fmoc-N-Me-Phe-OH Novabiochem?	77128-73-5	1g	$126	2026-04-30	Buy
Sigma-Aldrich	8.52137	Fmoc-N-Me-Phe-OH Novabiochem?	77128-73-5	5G	$504	2026-04-30	Buy
TCI Chemical	F1167	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-phenylalanine >98.0%(HPLC)(T)	77128-73-5	1g	$40	2026-04-30	Buy
TCI Chemical	F1167	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-phenylalanine >98.0%(HPLC)(T)	77128-73-5	5g	$121	2026-04-30	Buy
Usbiological	276966	N-alpha-Fmoc-N-alpha-Methyl-L-phenylalanine Asreported	77128-73-5	1g	$376	2026-06-03	Buy

Product number	Packaging	Price	Buy
8.52137	1g	$126	Buy
8.52137	5G	$504	Buy
F1167	1g	$40	Buy
F1167	5g	$121	Buy
276966	1g	$376	Buy

Fmoc-N-methyl-L-phenylalanine Chemical Properties,Uses,Production

Chemical Properties

White to off-white powder

Uses

N-Fmoc-N-methyl-L-phenylalanine is used in agrochemical, pharmaceutical and dyestuff field.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

9H-Fluoren-9-ylmethyl(4S)-4-benzyl-5-oxo-1,3-oxazolidine-3-carboxylate

84000-03-3

77128-73-5

Fmoc-phenylalanyl oxazolidinone (4.60 g, 11.6 mmol) was dissolved in chloroform (58 mL). To this solution, trifluoroacetic acid (2.68 mL, 34.8 equiv) and triethylsilane (5.56 mL, 34.8 equiv) were added sequentially. The reaction mixture was stirred at room temperature until the reaction was complete (24-72 hours). Upon completion of the reaction, the solution was concentrated and subsequently partitioned between ether and saturated sodium bicarbonate solution. The aqueous phase was combined, acidified to pH 2 with 5 M hydrochloric acid and extracted with ethyl acetate. The organic phase was collected, dried with anhydrous magnesium sulfate and concentrated to give a dark yellow oily product. The crude product was dissolved in dichloromethane and repeatedly evaporated to yield Fmoc-N-methylphenylalanine as a brown solid (3.73 g, 80% yield): melting point 106-107 °C; low-resolution mass spectrometry (ESI) m/z [M + H]+ 402.1 (100%); 1H NMR (300 MHz, CDCl3) δH (ppm) (rotated isomer ) 7.74 (2H, d, J = 7.5 Hz, ArH), 7.49 (1H, d, J = 7.8 Hz, ArH), 7.43 (1H, t, J = 6.9 Hz, ArH), 7.37 (2H, t, J = 7.5 Hz, ArH), 7.25-7.21 (6H, m, ArH), 6.95 (1H, d, J = 6.3 Hz , ArH), 4.89 (1H, dd, J = 5.1, 11.1 Hz, NCHCOOH), 4.59-4.53 (1H, m, (Ar)2CHCH2), 4.38 (2H, d, J = 14.4 Hz, CHCH2O), 3.41-3.35 (1H, m, CHCHHAr), 3.16-3.08 (1H m, CHCHHAr), 2.77 (3H, s, NCH3), 2.75 (3H, s, NCH3) (1H NMR data are consistent with literature reports); 13C NMR (75 MHz, CDCl3) δC (ppm) 175.5, 156.5, 143.4, 140.9, 136.4, 128.4, 128.3, 127.3, 126.7, 126.5, 124.6, 124.3, 119.6, 67.6, 60.7, 46.7, 34.3, 32.3.

IC 50

Plasmodium

References

[1] Journal of Organic Chemistry, 2005, vol. 70, # 17, p. 6918 - 6920
[2] European Journal of Organic Chemistry, 2013, # 21, p. 4509 - 4513
[3] Tetrahedron, 2014, vol. 70, # 14, p. 2351 - 2358
[4] Tetrahedron Letters, 2006, vol. 47, # 11, p. 1691 - 1694
[5] Angewandte Chemie - International Edition, 2008, vol. 47, # 14, p. 2595 - 2599

Fmoc-N-methyl-L-phenylalanine Preparation Products And Raw materials

Raw materials

9H-Fluoren-9-ylmethyl(4S)-4-benzyl-5-oxo-1,3-oxazolidine-3-carboxylate Triethylsilane Chloroform Trifluoroacetic acid

Preparation Products

Fmoc-N-methyl-L-phenylalanine Suppliers

Global( 244)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan jiayinglai technology CO.,LTD	9018 15982359653	1394531348@qq.com	China	2271	55
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alabiochem Tech.Co., Ltd.	512-58900862 400-0707518	sales@alabiochem.com	China	988	59
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66
Lavem Chine Pharm Company	028-62070218 18190869852	sales@lavemc.com	China	214	67

Supplier	Advantage
Sichuan jiayinglai technology CO.,LTD	55
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alabiochem Tech.Co., Ltd.	59
Energy Chemical	61
GL Biochem (Shanghai) Ltd	64
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
China DongFan Chemical Co.,LTD	66
Lavem Chine Pharm Company	67

View Lastest Price from Fmoc-N-methyl-L-phenylalanine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-14	Fmoc-N-Me-L-Phe-OH 77128-73-5		1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2026-08-13	Fmoc-N-methyl-L-phenylalanine 77128-73-5		1KG	98%	2000	Shenzhen Nexcon Pharmatechs Ltd.
2026-04-22	Fmoc-N-Me-Phe-OH 77128-73-5	$29.00		99.83%	10g	TargetMol Chemicals Inc.

Fmoc-N-Me-L-Phe-OH
77128-73-5
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

Fmoc-N-methyl-L-phenylalanine
77128-73-5
98%
Shenzhen Nexcon Pharmatechs Ltd.

Fmoc-N-Me-Phe-OH
77128-73-5
$29.00
99.83%
TargetMol Chemicals Inc.

Fmoc-N-methyl-L-phenylalanine Spectrum

Fmoc-N-methyl-L-phenylalanine(77128-73-5)¹HNMR

77128-73-5(Fmoc-N-methyl-L-phenylalanine)Related Search:

Methanol Kresoxim-methyl 9-Fluorenylmethyl chloroformate N-Methyl-L-alanine Methylparaben

Methyl salicylate Phenprobamate Fmoc-Phe-OH Tribenuron methyl Methyl acrylate

Fmoc-Aib-OH Basic Violet 1 D-Phenylalanine FMOC-N-METHYL-D-PHENYLALANINE L-Phenylalanine

Fmoc-OSu Metsulfuron methyl N-(tert-Butoxycarbonyl)sulfamide

1of4

FMOC-N-METHYL-L-PHENYLALANINE FMOC-N-ME-L-PHE-OH FMOC-N-ME-PHENYLALANINE FMOC-N-ALPHA-METHYL-L-PHENYLALANINE FMOC-MEPHE-OH FMOC-L-MEPHE-OH N-ALPHA-FMOC-N-ALPHA-METHYL-L-PHENYLALANINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-L-PHENYLALANINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-L-PHENYLALANINE FMOC-N-ME-PHE 98.5+% N-(9-Fluorenylmethyloxycarbonyl)-N-methyl-L-phenylalanine FMOC-N-METHYL-L-PHENYLALANINE LIQUID FMoc-MePhe-OH FMoc-N-α-Methyl-L-Phenylalanine Nα-Fmoc-Nα-Methyl-L-phenylalanine Fmoc-N-Me-Phe-OH >=99.0% (sum of enantiomers, HPLC) N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-phenylalanine (9H-Fluoren-9-yl)MethOxy]Carbonyl N-Me-Phe-OH (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-phenylpropanoic acid Fmoc-N-Me-Phe-OH Nα-Fmoc-Nα-Methyl-L-phenylalanine≥ 98% (HPLC) L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl- Fmoc-N-methyl-L-phenylalanine USP/EP/BP Fmoc-N-α-methyl-L-Phenylalanine Fmoc-N-mety)-L-phenylalanine Fmoc-N-Me-Phe-OH, 10 mM in DMSO N-Fmoc-N-methyl-L-phenylalanine (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid FMOC-N-ME-PHE-OH 77128-73-5 FM - FZ Analytical Standards Alphabetic Analytical Chromatography Product Catalog N-Methyl Amino Acids Amino Acids