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Fmoc-Phe-OH

Fmoc-Phe-OH structure

CAS No.: 35661-40-6

Chemical Name:: Fmoc-Phe-OH

Synonyms: FMOC-PHE-OH;FMOC-PHE;FMOC-L-PHE-OH;(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-phenylalanine;FMOC-L-PHE;FMOC-L-PHENYLALANINE;FMOC-PHENYLALANINE;Fmoc-Phenylalanine-OH;N-(9-FLUORENYLMETHOXYCARBONYL)-L-PHENYLALANINE;(S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-phenylpropanoic acid

CBNumber:: CB7411924

Molecular Formula:: C24H21NO4

Molecular Weight:: 387.43

MDL Number:: MFCD00037128

MOL File:: 35661-40-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:08:28

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Fmoc-Phe-OH Properties

Melting point	180-187 °C(lit.)
alpha	-38 º (c=1,DMF)
Boiling point	513.39°C (rough estimate)
Density	1.2379 (rough estimate)
refractive index	-39.5 ° (C=1, DMF)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMF (Sparingly, Sonicated), DMSO (Slightly)
pka	3.77±0.10(Predicted)
form	Powder
color	White
optical activity	[α]20/D 37°, c = 1 in DMF
BRN	3597808
Major Application	peptide synthesis
InChI	InChI=1S/C24H21NO4/c26-23(27)22(14-16-8-2-1-3-9-16)25-24(28)29-15-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21/h1-13,21-22H,14-15H2,(H,25,28)(H,26,27)/t22-/m0/s1
InChIKey	SJVFAHZPLIXNDH-QFIPXVFZSA-N
SMILES	C(O)(=O)[C@H](CC1=CC=CC=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference	35661-40-6(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335-H413

Precautionary statements

P261-P273-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

22-24/25-26

WGK Germany

HS Code

2924 29 70

Storage Class

11 - Combustible Solids

REACH Registrations

Active

NFPA 704

	0
1		0

Fmoc-Phe-OH price More Price(113)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.52016	Fmoc-Phe-OH Novabiochem?	35661-40-6	25g	$33.8	2026-04-30	Buy
Sigma-Aldrich	8.52016	Fmoc-Phe-OH Novabiochem?	35661-40-6	100g	$83	2026-04-30	Buy
Sigma-Aldrich	8.52016	Fmoc-Phe-OH Novabiochem?	35661-40-6	250g	$179	2026-04-30	Buy
Sigma-Aldrich	8.52016	Fmoc-Phe-OH Novabiochem^®	35661-40-6	500 g	$328	2026-04-30	Buy
Sigma-Aldrich	8.52016	Fmoc-Phe-OH Novabiochem?	35661-40-6	1kg	$588	2026-04-30	Buy

Product number	Packaging	Price	Buy
8.52016	25g	$33.8	Buy
8.52016	100g	$83	Buy
8.52016	250g	$179	Buy
8.52016	500 g	$328	Buy
8.52016	1kg	$588	Buy

Fmoc-Phe-OH Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powde

Uses

(Fmoc-Phe-OH) L-Phenylalanine (P319415) derivative, used in the preparation of peptides and deltorphin derivatives. A potential inhibitor of IGF-I and IGF-Binding Protein-5 complex.

General Description

Fmoc-Phe-OH is highly hydrophobic and dissolves easily in DMF and NMP. A photoresponsive hydrogel can be easily created by co-assembling Fmoc-Phe-OH and Azp without the need for chemical synthesis.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

Fmoc-L-phenylalanine is obtained via fragment coupling and modification in solid-phase peptide synthesis. The process involves coupling amino acids or dipeptides in solution or on a solid support using coupling agents like HCTU and DIEA, hydrogenolytic deprotection using palladium on carbon, cleavage of the peptide from the support using LiOHH2O, and a final coupling reaction of Fmoc-amino acid to the support using N,N-diisopropylcarbodiimide and DMAP. Subsequent precipitation and centrifugation yield the target product.

Fmoc-Phe-OH synthesis

Synthesis of Fmoc-Phe-OH from L-Phenylalanine and 9-Fluorenylmethyl chloroformate

Fmoc-Phe-OH Preparation Products And Raw materials

Raw materials

2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionic acid Fmoc-D-phenylalanine L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 2-propen-1-yl ester Fmoc-Phe-ol methyl (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-phenylpropanoate

L-Phenylalanine

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Preparation Products

L-Phe-D-Trp-OH Fmoc-Phe-Phe-OH ANGIOTENSIN I, HUMAN 9H-Fluoren-9-ylmethyl(4S)-4-benzyl-5-oxo-1,3-oxazolidine-3-carboxylate Angiotensin I/II (4-8)

Fmoc-Phe-OH Suppliers

Global Suppliers ( 524)

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Grand Hoyo Co., Ltd.	15377006636	670196467@qq.com	China	31	58
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
GenChem & GenPharm (Changzhou) Co., Ltd.	0519-85720003 18861157602	410649415@qq.com	China	111	58
Chengdu Tachem Co., Ltd	028-61682518; 19983060238	sales@tachem.cn	China	102	58
Chengdu ZY Biochemical Technology Co., Ltd.	88680086 13398185735	fengzilong@zybiochem.com	China	177	58
Chengdu Baishixing Science and Technology Industry Co.,Ltd	18111554528 19544347486	zhangyuchen@cd-bsx.com	China	82	55
Lanxi Xingnuo Import and Export Trading Co., Ltd	0579-8831088 15888978871	994350525@qq.com	China	23	58
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD	0838-2809458 13350585791	pharm@biots.cn	China	774	58
Zhangjiagang Specom Biochemical Co., Ltd.	512-0512-58992291,58992287 18606280718	admin@spbiochem.com	China	306	62
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
Wuhan Grand Hoyo Co., Ltd.	58
GL Biochem (Shanghai) Ltd	64
GenChem & GenPharm (Changzhou) Co., Ltd.	58
Chengdu Tachem Co., Ltd	58
Chengdu ZY Biochemical Technology Co., Ltd.	58
Chengdu Baishixing Science and Technology Industry Co.,Ltd	55
Lanxi Xingnuo Import and Export Trading Co., Ltd	58
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD	58
Zhangjiagang Specom Biochemical Co., Ltd.	62
J & K SCIENTIFIC LTD.	76

The synthesis and applications of Fmoc-Phe-OH
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View Latest Price from Fmoc-Phe-OH manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-17	FMOC-L-Phenylalanine 35661-40-6	10g	98%min	10KG	WUHAN FORTUNA CHEMICAL CO., LTD
2025-04-04	FMOC-L-Phenylalanine 35661-40-6	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2023-07-28	FMOC-L-Phenylalanine 35661-40-6	1kg	99%	1t/month	Chengdu Baishixing Science and Technology Industry Co.,Ltd

FMOC-L-Phenylalanine
35661-40-6
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

FMOC-L-Phenylalanine
35661-40-6
98%
Henan Aochuang Chemical Co.,Ltd.

FMOC-L-Phenylalanine
35661-40-6
$0.00
99%
Chengdu Baishixing Science and Technology Industry Co.,Ltd

Fmoc-Phe-OH Spectrum

FMOC-L-Phenylalanine(35661-40-6)MS FMOC-L-Phenylalanine(35661-40-6)¹HNMR FMOC-L-Phenylalanine(35661-40-6)¹³CNMR FMOC-L-Phenylalanine(35661-40-6)IR1 FMOC-L-Phenylalanine(35661-40-6)IR2 FMOC-L-Phenylalanine(35661-40-6)Raman

35661-40-6 (Fmoc-Phe-OH) Related Search:

L-Alanine Fmoc-Tyr(tBu)-OH Fmoc-Pro-OH 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butanoic acid Fmoc-L-glutamic acid 5-tert-butyl ester

Nalpha-Fmoc-Ndelta-trityl-L-glutamine Fmoc-Asn(Trt)-OH FMOC-O-tert-Butyl-L-threonine FMOC-O-tert-Butyl-L-serine Fmoc-Gly-OH

Fmoc-Trp(Boc)-OH FMOC-L-Methionine FMOC-L-Valine Fmoc-Asp(OtBu)-OH FMOC-S-trityl-L-cysteine

Fmoc-Lys(Boc)-OH FMOC-Ala-OH Fmoc-L-glutamic acid

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(2S)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-phenylpropanoate N-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine ,98% N-(9H-Fluorene-9-ylmethoxycarbonyl)phenylalanine N-Fmoc-L-Phe-OH L-PHENYLALANINE-N-FMOC N-Fmoc-L-phenylalanine Fmoc-Phe-OH Fmoc-Phe-OH 98% NSC 334293 FMOC-L-phenylalanine, 98.0% L-Phenyl-d5-alanine-d3-N-FMOC Fmoc-L-phenylalanine≥ 99.7% (HPLC, Chiral purity) FMOC-L-PHE-OH(35661-40-6) (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-phenylpropanoic acid 9-FLUORENYLMETHOXYCARBONYL-L-PHENYLALANINE N-(9-FLUORENYLMETHOXYCARBONYL)-L-PHENYLALANINE N-9-FLUORENYLMETHYLOXYCARBONYL-L-PHENYLALANINE N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-PHENYLALANINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-PHENYLALANINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-PHENYLALANINE N-ALPHA-FMOC-L-PHENYLALANINE N-FMOC-PHE-OH N-FMOC-L-PHENYLALANINE N-FMOC-L-PHE (S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PHENYL-PROPIONIC ACID N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-phenyl-L-alanine L-PHENYLALANINE-15N, N-FMOC DERIVATIVE 9 FMOC-L-PHENYLALANINE 98+% Fmoc-L-Phc-OH L-Phenylalanine-ring-13C6-N-FMOC L-Phenylalanine-UL-13C9, 15N-N-FMOC N-Fmoc-L-phenylalanine, 98+% FMOC-L-PHENYLALNINE extrapure N-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine, Fmoc-L-phenylalanine (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenylpropanoate FMOC-PHE-OH FMOC-PHENYLALANINE (9H-Fluoren-9-yl)MethOxy]Carbonyl Phe-OH N-FMOC-PHE-OH ( N-FMOC-L-PHENYLALANINE) N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine> FMOC-PHE-OH 100 G FMOC-PHE-OH 25 G FMOC-PHE-OH 250 G L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]- FMOC-L-Phenylalanine USP/EP/BP Fmoc-l-phenyl alanine, puriss, 99% FMOC-L-Phenylalanine extrapure, 99% (2S)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]phenylalanine (((9H-Fluoren-9-yl)methoxy)carbonyl)-L-phenylalanine (S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-phenylpropanoic acid Fmoc-Phenylalanine-OH FMOC-L-PHE FMOC-L-PHENYLALANINE FMOC-L-PHE-OH FMOC-PHE 35661-40-6 35561-40-6 C24H20NO4