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Tri(Ethylene Glycol) DI-P-Toluenesulfonate

Tri(Ethylene Glycol) DI-P-Toluenesulfonate structure

CAS No.: 19249-03-7

Chemical Name:: Tri(Ethylene Glycol) DI-P-Toluenesulfonate

Synonyms: (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-Methylbenzenesulfonate);TSO-PEG3-OTS;TRIETHYLENE GLYCOL DITOSYLATE;1,10-Ditosyl-1,4,7,10-tetraoxadecane;TRIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE);TRIETHYLGLYCOL DI-P-TOSYLATE;Tos-PEG4-Tos;Tos-PEG3-Tos;Bis-Tos-PEG3;CAS_19249-03-7

CBNumber:: CB4227531

Molecular Formula:: C20H26O8S2

Molecular Weight:: 458.55

MDL Number:: MFCD00048096

MOL File:: 19249-03-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:39:38

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Tri(Ethylene Glycol) DI-P-Toluenesulfonate Properties

Melting point	78-82 °C(lit.)
Boiling point	534.03°C (rough estimate)
Density	1.3164 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in ethanol.
form	powder to crystal
color	White to Almost white
BRN	632509
InChI	InChI=1S/C20H26O8S2/c1-17-3-7-19(8-4-17)29(21,22)27-15-13-25-11-12-26-14-16-28-30(23,24)20-9-5-18(2)6-10-20/h3-10H,11-16H2,1-2H3
InChIKey	KCONMNWPRXAWKK-UHFFFAOYSA-N
SMILES	C(OCCOS(C1=CC=C(C)C=C1)(=O)=O)COCCOS(C1=CC=C(C)C=C1)(=O)=O
CAS DataBase Reference	19249-03-7(CAS DataBase Reference)
EPA Substance Registry System	Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, bis(4-methylbenzenesulfonate) (19249-03-7)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

29093090

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

Tri(Ethylene Glycol) DI-P-Toluenesulfonate price More Price(82)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	339032	Triethylene glycol di(p-toluenesulfonate) 98%	19249-03-7	10g	$60.1	2026-04-30	Buy
TCI Chemical	T1488	Triethylene Glycol Bis(p-toluenesulfonate) >97.0%(HPLC)	19249-03-7	10g	$76	2026-04-30	Buy
TCI Chemical	T1488	Triethylene Glycol Bis(p-toluenesulfonate) >97.0%(HPLC)	19249-03-7	25g	$130	2026-04-30	Buy
TRC	TRC-E917743-50MG	Triethylene Glycol Ditosylate	19249-03-7	50mg	$65	2026-06-03	Buy
TRC	TRC-E917743-500MG	Triethylene Glycol Ditosylate	19249-03-7	500mg	$103	2026-06-03	Buy

Product number	Packaging	Price	Buy
339032	10g	$60.1	Buy
T1488	10g	$76	Buy
T1488	25g	$130	Buy
TRC-E917743-50MG	50mg	$65	Buy
TRC-E917743-500MG	500mg	$103	Buy

Tri(Ethylene Glycol) DI-P-Toluenesulfonate Chemical Properties, Uses, Production

Description

Tos-PEG4-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Chemical Properties

WHITE POWDER

Uses

Tri(ethylene glycol) di-p-toluenesulfonate is used in the synthesis of 1-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl] ethanone.

Synthesis

2,2'-[1,2-ethanediylbis(oxy)]bisethanol and p-toluenesulfonyl chloride can be used as raw materials for the synthesis of Tri(Ethylene Glycol) DI-P-Toluenesulfonate.

References

[1] Organic and Biomolecular Chemistry, 2006, vol. 4, # 11, p. 2082 - 2087
[2] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 14, p. 4841 - 4856
[3] Organic and Biomolecular Chemistry, 2015, vol. 13, # 30, p. 8335 - 8348
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 17, p. 7840 - 7855
[5] Journal of Organic Chemistry, 1992, vol. 57, # 24, p. 6678 - 6680

Tri(Ethylene Glycol) DI-P-Toluenesulfonate Preparation Products And Raw materials

Raw materials

Tosyl chloride Triethylene glycol Potassium hydroxide Dichloromethane

Preparation Products

Ethane, 1,2-bis(2-bromoethoxy)- 2-[2-(2-Fluoroethoxy)ethoxy]ethanol 2-[2-(2-Azidoethoxy)ethoxy]ethanamine 1,2-Bis(2-chloroethoxy)ethane

Tri(Ethylene Glycol) DI-P-Toluenesulfonate Suppliers

Global Suppliers ( 262)

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Highfine Biotech Co., Ltd	0512-69209928 18796809688	zhouyingxiang@highfine.com	China	472	75
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55
Tianjin Nuokang Pharmaceutical Technology Co., Ltd.	022-23989838 13810451150	44766350@qq.com	China	2725	58
Suzhou BEC Biological Technology Co., Ltd	+86-512-68095917 17712685869	sales@bek.com.cn	China	142	59
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60

Supplier	Advantage
Suzhou Highfine Biotech Co., Ltd	75
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
Tianjin Nuokang Pharmaceutical Technology Co., Ltd.	58
Suzhou BEC Biological Technology Co., Ltd	59
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61
JinYan Chemicals(ShangHai) Co.,Ltd.	60

View Latest Price from Tri(Ethylene Glycol) DI-P-Toluenesulfonate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-24	(ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) 19249-03-7		1g	98%	1g/bottle, 10g/bottle, 100g/bottle	XIAMEN SINOPEG BIOTECH CO., LTD.
2025-06-07	Tos-PEG4-Tos 19249-03-7		500g	>98.00%	500g	Xian confluore Biological Technology Co., Ltd.
2021-07-13	TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE 19249-03-7	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

(ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)
19249-03-7
98%
XIAMEN SINOPEG BIOTECH CO., LTD.

Tos-PEG4-Tos
19249-03-7
$0.00
>98.00%
Xian confluore Biological Technology Co., Ltd.

TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE
19249-03-7
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Tri(Ethylene Glycol) DI-P-Toluenesulfonate Spectrum

TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE(19249-03-7)¹HNMR TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE(19249-03-7)Raman

19249-03-7 (Tri(Ethylene Glycol) DI-P-Toluenesulfonate) Related Search:

2,2-Dimethyl-1,3-propanediol Triethylene glycol dimethacrylate Tos-PEG9-t-butyl ester Tos-PEG7-t-butyl ester Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate)

ALLYL ISOVALERATE Magnesium Bisglycinate Risedronic acid Benzonitrile, 3-bromo-2-fluoro- (9CI) Tos-PEG3-t-butyl ester

Tetraethylene glycol di-p-tosylate Tos-PEG3-CH2CO2tBu Tos-PEG13-t-butyl ester Tos-PEG5-CH2CO2t-butyl ester 1-Cbz-2-piperidinecarboxylic acid

Tos-PEG5-THP 5-Nitro-1H-pyrazole-3-carboxylic acid methyl ester 4-Fluoro-3'-iododiphenyl ether

1of4

1,10-Ditosyl-1,4,7,10-tetraoxadecane 1,8-Bis(tosyloxy)-3,6-dioxaoctane Bis(4-methylbenzenesulfonic acid)3,6-dioxa-1,8-octanediyl ester Bis(4-methylbenzenesulfonic acid)ethylenebis(oxyethylene) ester Bis(p-toluenesulfonic acid)ethylenebisoxybisethylene ester Triethylene glycol di-p-tosylate,98% Triethleneglycol ditosylate Triethylene glycol ditoluenesulfonate. ETHANOL22OXYBIS21ETHANEDIYLOXYBISBIS4METHYLBENZENESULPHONATE ethanol,2,2'-[oxybis(2,1-ethanediyloxy)]bis-,bis(4-methysbenzenesulfonate) 2,2μ-(Ethylenedioxy)diethyl ditosylate, Triethylene glycol ditosylate 1,2-Bis[2-(p-toluenesulfonyloxy)ethoxy]ethane(PEG3-Tos) 4-methylbenzenesulfonic acid 2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl ester CAS_19249-03-7 1,2-Bis[2-(p-toluenesulfonyloxy)ethoxy]ethane 1,2-Bis(2-tosyloxyethoxy)ethane 2,2'-(Ethylenedioxy)diethyl Ditosylate Triethylene Glycol Di-p-tosylate Tos-PEG4-Tos Tos-PEG3-Tos PEG3-Tos 1,2-Bis[2-(p-toluenesulfonyloxy)ethoxy]ethane Triethylene glycol bis(p-toluenesulfonate)≥ 98%(HPLC) TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE TRIETHYLENE GLYCOL DI-P-TOSYLATE LABOTEST-BB LT00248460 2,2'-(ETHYLENEDIOXY)DIETHYL DITOSYLATE 1,2-BIS[2-(P-TOLUENESULFONYLOXY)ETHOXY]ETHANE 1,2-BIS(2-TOSYLOXYETHOXY)ETHANE 2,2-(Ethylenedioxy)diethyl ditosylat Bis-Tos-PEG3 Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, 1,1'-bis(4-methylbenzenesulfonate) 2-2-2-(p-Tolylsulfonyloxy)ethoxyethoxyethyl 4-methylbenzenesulfonate 2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl4-methylbenzenesulfonate Triethyleneglycol-di-p-toluenesulphonate Triethylene glycol di(p-toluenesulfonate) 19249-03-7 TosO-(CH2CH2O)3-Tos Tos-PEG3-Tos/Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, 1,1'-bis(4-methylbenzenesulfonate) (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) , Triethylene glycol bis(p-toluenesulfonate) 2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethyl 4-methylbenzene-1-sulfonate Triethylene glycol di(p-toluenesulfonate) Trivinyl glycol (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfote) TRIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE) (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-Methylbenzenesulfonate) TRIETHYLGLYCOL DI-P-TOSYLATE TRIETHYLENE GLYCOL DITOSYLATE TSO-PEG3-OTS Triethylene glycol diethyl ether 19249-03-7 C20H26O8S2 CH3C6H4SO3CH2CH2OCH22 Organic Building Blocks Sulfur Compounds Tosylates Building Blocks