ChemicalBook >> CAS DataBase List >>D-(-)-3-Acetylthio-2-methylpropionic acid

D-(-)-3-Acetylthio-2-methylpropionic acid

D-(-)-3-Acetylthio-2-methylpropionic acid structure

CAS No.: 76497-39-7

Chemical Name:: D-(-)-3-Acetylthio-2-methylpropionic acid

Synonyms: Captopril Impurity K;Captopril Impurity V;Captopril Impurity 7;Captopril EP Impurity G (S-Isomer);(2S)-3-(Acetylthio)-2-methylpropano;(S)-β-(Acetylmercapto)isobutyric acid;(S)-(-)-3-(ACETYLTHIO)ISOBUTYRIC ACID;D-(-)-3-Acetylthio-2-Methylpropionic A;Captopril Impurity G as (S)-enantiomer;D-3-(Acetylthio)-2-methylpropanoic acid

CBNumber:: CB4240644

Molecular Formula:: C6H10O3S

Molecular Weight:: 162.21

MDL Number:: MFCD00038563

MOL File:: 76497-39-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:13:16

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D-(-)-3-Acetylthio-2-methylpropionic acid Properties

Melting point	5 °C
Boiling point	120-132 °C (1 mmHg)
alpha	-46 º (c=1, 96% EtOH)
Density	1.178 g/mL at 20 °C(lit.)
refractive index	n20/D 1.490
Flash point	>230 °F
storage temp.	Store at 0-5°C
solubility	Chloroform (Slightly), Ethanol (Sparingly), Methanol (Slightly)
form	liquid
pka	4.22±0.10(Predicted)
Water Solubility	INSOLUBLE
InChI	InChI=1S/C6H10O3S/c1-4(6(8)9)3-10-5(2)7/h4H,3H2,1-2H3,(H,8,9)/t4-/m1/s1
InChIKey	VFVHNRJEYQGRGE-SCSAIBSYSA-N
SMILES	C(O)(=O)[C@H](C)CSC(C)=O
CAS DataBase Reference	76497-39-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

C,T

Risk Statements

34-36-24/25

Safety Statements

26-36/37/39-45

RIDADR

UN 3265 8/PG 2

WGK Germany

HS Code

29309070

REACH Registrations

Active

NFPA 704

	1
2		0

D-(-)-3-Acetylthio-2-methylpropionic acid price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A1334	(S)-(-)-3-(Acetylthio)-2-methylpropionic Acid >98.0%(T)	76497-39-7	5mL	$74	2021-12-16	Buy
TCI Chemical	A1334	(S)-(-)-3-(Acetylthio)-2-methylpropionic Acid >98.0%(T)	76497-39-7	25mL	$220	2021-12-16	Buy
Usbiological	241761	S-(-)-3-(Acetylthio)-2-methylpropionic acid 99+% ee (GC) ≥99%ee(GC)	76497-39-7	1g	$159	2026-06-03	Buy
Usbiological	241761	S-(-)-3-(Acetylthio)-2-methylpropionic acid 99+% ee (GC) ≥99%ee(GC)	76497-39-7	5g	$207	2026-06-03	Buy
Usbiological	260661	D(-)S-Acetyl-beta-mercapto isobutyric acid Asreported	76497-39-7	10g	$382	2026-06-03	Buy

Product number	Packaging	Price	Buy
A1334	5mL	$74	Buy
A1334	25mL	$220	Buy
241761	1g	$159	Buy
241761	5g	$207	Buy
260661	10g	$382	Buy

D-(-)-3-Acetylthio-2-methylpropionic acid Chemical Properties, Uses, Production

Chemical Properties

clear colourless to slightly yellow liquid

Uses

S-Acetylthio-2-methylpropionic acid (S-AMPA) is a key chiral intermediate for Captopril (C175750) and other hypertension drugs.

Uses

ACE-inhibitors.

D-(-)-3-Acetylthio-2-methylpropionic acid synthesis

Synthesis of D-(-)-3-Acetylthio-2-methylpropionic acid from 3-Acetylthio-2-methylpropanoic acid

D-(-)-3-Acetylthio-2-methylpropionic acid Preparation Products And Raw materials

Raw materials

methyl 3-(acetylthio)-2-methyl-propanoate 3-Acetylthio-2-methylpropanoic acid 3-Mercaptoisobutyric acid D -(-)-S-acetyl-beta-mercapto- isobutyric acid (2S)-2-methyl-3-sulfanylpropanoic acid, (S)-3-mercapto-2-methyl-propionic acid, (S)-3-mercapto-2-methylpropanoic acid, (S)-3-mercapto-2-methylpropanoicacid, 3-merkapto-2-D-methylpropanoic acid, 3-mercapto-2-methylpropionic acdi, 3-mercapto-2-methylpropionic acid

Acetic anhydride

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Preparation Products

(R)-(+)-3-(Acetylthio)isobutyric acid methyl ester

D-(-)-3-Acetylthio-2-methylpropionic acid Suppliers

Global Suppliers ( 148)

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangsu Greature Bio-Medicine Co., Ltd.	0512-85557988 18662338937	frank.wang@greature.com.cn	China	145	58
Shandong Jiuyue Biotechnology Co., Ltd.	15553333686	643971@qq.com	China	540	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
Jiangsu Greature Bio-Medicine Co., Ltd.	58
Shandong Jiuyue Biotechnology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Capot Chemical Co., Ltd	66
Shanghai Longsheng chemical Co.,Ltd.	59
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64

View Latest Price from D-(-)-3-Acetylthio-2-methylpropionic acid manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-16	Captopril EP Impurity G 76497-39-7		10mg	98	10000000	Moxin Chemicals
	2019-07-06	D-(-)-3-Acetylthio-2-methylpropionic acid 76497-39-7	$1.00	1G	98%	100KG	Career Henan Chemical Co

Captopril EP Impurity G
76497-39-7
98
Moxin Chemicals

D-(-)-3-Acetylthio-2-methylpropionic acid
76497-39-7
$1.00
98%
Career Henan Chemical Co

D-(-)-3-Acetylthio-2-methylpropionic acid Spectrum

D-(-)-3-Acetylthio-2-methylpropionic acid(76497-39-7)MS D-(-)-3-Acetylthio-2-methylpropionic acid(76497-39-7)¹HNMR D-(-)-3-Acetylthio-2-methylpropionic acid(76497-39-7)¹³CNMR D-(-)-3-Acetylthio-2-methylpropionic acid(76497-39-7)IR1

76497-39-7 (D-(-)-3-Acetylthio-2-methylpropionic acid) Related Search:

Butyl levulinate 3-Mercaptopropionic acid Levulinic acid Folic acid Isobutyric acid

2,2-Bis(hydroxymethyl)propionic acid Acetyl chloride Methyl levulinate Ethyl 2-(Chlorosulfonyl)acetate Acetylacetone

Citric acid Glycine Ascoric Acid 2-Mercaptoethanol Captopril

Propionic acid 3-ACETYLTHIO-2-METHYLPROPIONIC ACID,DL-BETA-ACETYLTHIO-ALPHA-METHYLPROPIONIC ACID,3-ACETYLTHIO-2-METHYLPROPANOIC ACID (R)-(+)-3-(Acetylthio)isobutyric acid methyl ester

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D(-)S-ACETYL-BETA-MERCAPTO ISOBUTYRIC ACID D-(S)-3-ACETYL-3-MERCAPTO-2-METHYL PROPANOIC ACID D-(-)-3-ACETYLSULFANYL-2-METHYLPROPIONIC ACID d-(-)-3-acetylthio-2-methylpropionic acid (S)-β-(Acetylmercapto)isobutyric acid D-3-(Acetylthio)-2-methylpropanoic acid D-(S)-3-Acetylthio-2-methylpropionic acid (S)-(-)-3-(ACETYLTHIO)-2-METHYLPROPIONI& (-)-3-(Acetylthio)-2-methylpropanoic acid (Captopril Intermediate) (S)-BETA-(ACETYLMERCAPTO)ISOBUTYRIC ACID (S)-(-)-BETA-ACETYLTHIO-2-METHYLPROPIONIC ACID (S)-(-)-3-(ACETYLMERCAPTO)ISOBUTYRIC ACID (S)-(-)-3-ACETYLTHIO-2-METHYLPROPANOIC ACID (S)-(-)-3-(ACETYLTHIO)-2-METHYLPROPIONIC ACID (S)-(-)-3-(ACETYLTHIO)ISOBUTYRIC ACID (S)-ACETYL-3-MERCAPTO-2-METHYLPROPANOIC ACID (S)-(-)-ACETYLTHIO 2-METHYLPROPIONIC ACID (S)-β-(Acetylmercapto)isobutyric acid, D-(-)-S-Acetyl-β-mercaptoisobutyric acid Propanoic acid, 3-(acetylthio)-2-methyl-, (2S)- (2S)-3-Acetylsulfanyl-2-methylpropanoate (2S)-2-Methyl-3-(acetylthio)propionic acid (S)-2-Methyl-3-(acetylthio)propionic acid D(-)-S-Acetyl-beta-mercaptoisobutyric acid,99% (S)-3-Acetylsulfanyl-2-Methylpropionic Acid D-(-)-3-Acetylthio-2-Methylpropionic A (2S)-3-(Acetylsulphanyl)-2-methylpropanoic acid, (2S)-3-(Acetylthio)-2-methylpropionic acid Captopril Impurity K Captopril EP Impurity G (S-Isomer) (2S)-3-acetylthio-2-methylpropionic acid, D-(-)-S-3-acetylthio-2-methylpropanoic acid, (2S)-3-Acetylthio-2-methylpropanoic acid, (S)-3-(acetylthio)isobutyric acid, (S)-(-)-acetyl-β-mercaptoisobutyric acid, D-(-)-S-acetyl-β-mercaptoisobutyric acid, (S)-3-acetylsulfanyl-2-methyl-propionic acid (S)-(-)-3-(Acetylthio)-2-methylpropionic acid≥ 99% ee (GC) Captopril Impurity V (2S)-3-acetylthio-2-methylpropionic acid (2S)-3-(Acetylthio)-2-methylpropano Captopril Impurity 7 Captopril EP Impurity G as (S)-enantiomer Captopril Impurity G as (S)-enantiomer 76497-39-7 79497-39-7 C6H10O3S Carboxylic Acids (Chiral) Chiral Building Blocks Asymmetric Synthesis Organic Building Blocks Thiocarbonyl Compounds Carboxylic Acids (Chiral) Chiral Building Blocks Synthetic Organic Chemistry