4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde
- CAS No.
- 14160-91-9
- Chemical Name:
- 4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde
- Synonyms
- 4,6-Dichloro-2-Methyl-5-pyriMidinecarboxaldehyde;5-Pyrimidinecarboxaldehyde, 4,6-dichloro-2-methyl-;2-Methyl-4,6-dichloropyrimidin-5-formaldehyde;4,6-Dichloro-2-methylpyrimidin-5-carbaldehyde;4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde;4,6-Dichloro-2-methyl-5-pyrimidinecarbaldehyde;4,6-dichloro-2-methylpyrimidine-5-formaldehyde;4,6-DICHLORO-2-METHYLPYRIMIDINE-5-CARBALDEHYDE ISO 9001：2015 REACH
- CBNumber:
- CB42452841
- Molecular Formula:
- C6H4Cl2N2O
- Molecular Weight:
- 191.01
- MDL Number:
- MFCD09909782
- MOL File:
- 14160-91-9.mol
- MSDS File:
- SDS
| Boiling point | 276.2±35.0 °C(Predicted) |
|---|---|
| Density | 1.495±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | -5.44±0.39(Predicted) |
| Appearance | Off-white to yellow Solid |
| InChI | InChI=1S/C6H4Cl2N2O/c1-3-9-5(7)4(2-11)6(8)10-3/h2H,1H3 |
| InChIKey | DOMBYPXLCGLBRD-UHFFFAOYSA-N |
| SMILES | C1(C)=NC(Cl)=C(C=O)C(Cl)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P261 |
| HS Code | 2933599590 |
4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | PAA16091 | 4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde | 14160-91-9 | 0.25g | $250 | 2026-06-04 | Buy |
| Biosynth | PAA16091 | 4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde | 14160-91-9 | 2.5g | $855.5 | 2026-06-04 | Buy |
| Apolloscientific | OR55083 | 4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde 97% | 14160-91-9 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR55083 | 4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde 97% | 14160-91-9 | 250mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR55083 | 4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde 97% | 14160-91-9 | 1g | $29 | 2026-06-04 | Buy |
4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde Chemical Properties, Uses, Production
Uses
2-Methyl-4,6-dichloropyrimidine-5-carboxaldehyde is an aldehyde derivative that can be used as a pharmaceutical intermediate.
Synthesis
15263-76-0
14160-91-9
The general procedure for the synthesis of 2-methyl-4,6-dichloropyrimidine-5-carbaldehyde from 2N-(4-((3-propylamino)amino)phenyl)-4N-(5-cyclopropane-1H-pyrazolyl)pyrimidine-2,4-diamine hydrochloride is as follows: Intermediate 45: Synthesis of 4,6-dichloro-2-methylpyrimidine-5-carbaldehyde 1. water (0.199 mL, 11.03 mmol) was slowly added to phosphorus trichloride (7.28 mL, 78.11 mmol) under ice bath conditions. 2. N,N-dimethylaniline (0.291 mL, 2.30 mmol) was then added. 3. N-((4,6-dihydroxy-2-methylpyrimidin-5-yl)methylene)-N-methylmethylammonium chloride (Intermediate 46; 1 g, 4.59 mmol) was added to the above solution in batches at room temperature. 4. The resulting suspension was stirred and reacted at 120 °C for 20 hours. 5. Upon completion of the reaction, the reaction mixture was slowly poured into an ice/chloroform mixture. 6. The chloroform layer was washed sequentially with saturated NaHCO3 solution (200 mL) and saturated brine (100 mL). 7. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give the crude product. 8. The crude product was purified by fast silica gel column chromatography with an elution gradient of 5% to 10% EtOAc in isohexane solution. 9. The pure grades were collected and concentrated to dryness under reduced pressure to give 2-methyl-4,6-dichloropyrimidine-5-carbaldehyde (0.160 g, yield 18.23%) as a white solid. Product characterization: 1H NMR (400 MHz, CDCl3) δ 2.77 (3H, s), 10.44 (1H, s).
References
[1] Patent: WO2011/121350, 2011, A1. Location in patent: Page/Page column 118-119
4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Baiqi Biomedical Co. Ltd | 0536-8998390 13173160180 | sales@baiqpharm.com | China | 581 | 58 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Suzhou Chukai PharmaTech | 0512-88812066 | wenlongfcb@qq.com | China | 110 | 62 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3987 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| shanghai cooperpharm co.,LTD . | +86-021-58975553 | sales@cooperpharm.com | China | 1210 | 56 |
| Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 587 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-08-25 | 4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde
14160-91-9
|
$1.10-9.90 | 1KG | 99% min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-08-20 | 4,6-DICHLORO-2-METHYLPYRIMIDINE-5-CARBALDEHYDE
14160-91-9
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2026-06-30 | 4,6-DICHLORO-2-METHYLPYRIMIDINE-5-CARBALDEHYDE
14160-91-9
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 4,6-Dichloro-2-methylpyrimidine-5-carbaldehyde
14160-91-9
- $1.10-9.90
- 99% min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 4,6-DICHLORO-2-METHYLPYRIMIDINE-5-CARBALDEHYDE
14160-91-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4,6-DICHLORO-2-METHYLPYRIMIDINE-5-CARBALDEHYDE
14160-91-9
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
