4,4'-Difluorobenzhydrol
- CAS No.
- 365-24-2
- Chemical Name:
- 4,4'-Difluorobenzhydrol
- Synonyms
- 4,4-DIFLUOROBENZHYDROL;4,4'-Difluorobenzhyd;4’4-Difluorobenzhydrd;LABOTEST-BB LT00233218;Flunarizine Impurity 8;Flunarizine Impurity 4;2,4-pyridinediolC5H5NO2;4,4'-Difluorobenzhydrol;Difluorodiphenylmethanol;4,4'-difluorodibenzohydrol
- CBNumber:
- CB4245331
- Molecular Formula:
- C13H10F2O
- Molecular Weight:
- 220.21
- MDL Number:
- MFCD00000357
- MOL File:
- 365-24-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Bis(4-fluorophenyl)methanol 98% | 222682 | 5g | $49.6 |
| 4,4'-Difluorobenzhydrol >98.0%(GC) | D1795 | 25g | $54 |
| Bis(4-fluorophenyl)methanol 98% | B39696 | 5g | $18 |
| Bis(4-fluorophenyl)methanol 98% | B39696 | 10g | $22 |
| Bis(4-fluorophenyl)methanol 98% | B39696 | 25g | $24 |
| More product size | |||
| Melting point | 43-45 °C(lit.) |
|---|---|
| Boiling point | 143 °C3 mm Hg(lit.) |
| Density | 1.2031 (estimate) |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 13.41±0.20(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| BRN | 2332258 |
| InChI | InChI=1S/C13H10F2O/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8,13,16H |
| InChIKey | WCTZPQWLFWZYJE-UHFFFAOYSA-N |
| SMILES | C(O)(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1 |
| CAS DataBase Reference | 365-24-2(CAS DataBase Reference) |
| NIST Chemistry Reference | 4,4'-Difluorobenzhydrol(365-24-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-36/37-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29062900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4,4'-Difluorobenzhydrol price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 222682 | Bis(4-fluorophenyl)methanol 98% | 365-24-2 | 5g | $49.6 | 2026-04-30 | Buy |
| TCI Chemical | D1795 | 4,4'-Difluorobenzhydrol >98.0%(GC) | 365-24-2 | 25g | $54 | 2026-04-30 | Buy |
| Synthonix | B39696 | Bis(4-fluorophenyl)methanol 98% | 365-24-2 | 5g | $18 | 2026-05-06 | Buy |
| Synthonix | B39696 | Bis(4-fluorophenyl)methanol 98% | 365-24-2 | 10g | $22 | 2026-05-06 | Buy |
| Synthonix | B39696 | Bis(4-fluorophenyl)methanol 98% | 365-24-2 | 25g | $24 | 2026-05-06 | Buy |
4,4'-Difluorobenzhydrol Chemical Properties,Uses,Production
Chemical Properties
white to yellowish crystalline flakes or powder
Uses
4-Chloropyridine-3-sulfonyl Chloride can be used for antiinflammatory properties.
General Description
Bis(4-fluorophenyl)methanol is one of the degardation product of flunarizine hydrochloride (FLZ).
Synthesis
345-92-6
365-24-2
GENERAL METHODS: NaBH4 (0.6 mol) was added batchwise to a stirred solution of 4,4'-difluorobenzophenone (1.0 mol) in methanol (2 volumes) at room temperature for 45 min. The reaction mixture was stirred at ambient temperature for 2-3 h (progress of the reaction was monitored by TLC), and upon completion of the reaction, the reaction was diluted with water (750 mL), the pH was adjusted to 4 with acetic acid, and the reaction was subsequently extracted with dichloromethane (2 x 400 mL). The organic layer was washed with water (200 mL), dried with anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give pure 4,4'-difluorodiphenylmethanol as a white to off-white solid in 93-97% yield. To a stirred solution of 4,4'-difluorodiphenylmethanol (1.0 mol) in toluene (370 mL) at room temperature was added concentrated hydrochloric acid (35% aqueous, 370 mL) and tetrabutylammonium bromide (0.01 mol). The mixture was continued to be stirred at 40-45 °C for 6-7 h. After TLC showed that the reaction was complete, the mixture was cooled to room temperature. The organic layer was separated and concentrated under vacuum to give crude 4,4'-difluorodiphenylmethyl chloride as a light brown liquid in 95-97% yield. Anhydrous piperazine (5.0 mol) was slowly added to a solution of 4,4'-difluorodiphenylmethyl chloride (0.96 mol) in toluene (380 mL) at 60-70 °C for 45-60 minutes. The resulting mixture was heated at 90-100°C for 8-10 hours with stirring. After completion of the reaction the mixture was cooled and water (380 mL) was added to separate the organic layer. The organic layer was washed with a 1:1 mixture of concentrated hydrochloric acid and water (2 x 350 mL) and subsequently neutralized with 20% NaOH solution (750 mL). The aqueous layer was again extracted with toluene (2×300 mL), and the organic layers were combined, dried with anhydrous sodium sulfate, and concentrated in vacuum to afford the pure 4,4'-difluorodiphenylmethylpiperazine derivative as a white to off-white solid in 88% yield.
References
[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 28, p. 5094 - 5096
[2] Synthesis, 2010, # 12, p. 1989 - 1991
[3] Synthetic Communications, 2014, vol. 44, # 5, p. 600 - 609
[4] Organic Letters, 2000, vol. 2, # 5, p. 659 - 661
[5] Patent: , 2016, . Location in patent: Paragraph 0016; 0018; 0019; 0020; 0021; 0022
4,4'-Difluorobenzhydrol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 4000 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29817 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2949 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 4,4'-Difluorobenzhydrol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-26 | 4,4'-Difluorobenzhydrol
365-24-2
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2025-05-23 | 4,4'-Difluorobenzhydrol
365-24-2
|
US $10.00 / kg | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2024-06-18 | 4,4'-Difluorobenzhydrol
365-24-2
|
US $1.00 / KG | 1KG | 99% | 20t | Shaanxi Dideu Medichem Co. Ltd |
-
- 4,4'-Difluorobenzhydrol
365-24-2
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 4,4'-Difluorobenzhydrol
365-24-2
- US $10.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- 4,4'-Difluorobenzhydrol
365-24-2
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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