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4,4'-Difluorobenzhydrol

4,4'-Difluorobenzhydrol Structure
4,4'-Difluorobenzhydrol structure
CAS No.
365-24-2
Chemical Name:
4,4'-Difluorobenzhydrol
Synonyms
4,4-DIFLUOROBENZHYDROL;4,4'-Difluorobenzhyd;4’4-Difluorobenzhydrd;LABOTEST-BB LT00233218;Flunarizine Impurity 8;Flunarizine Impurity 4;2,4-pyridinediolC5H5NO2;4,4'-Difluorobenzhydrol;Difluorodiphenylmethanol;4,4'-difluorodibenzohydrol
CBNumber:
CB4245331
Molecular Formula:
C13H10F2O
Molecular Weight:
220.21
MDL Number:
MFCD00000357
MOL File:
365-24-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:30:06
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4,4'-Difluorobenzhydrol Properties

Melting point 43-45 °C(lit.)
Boiling point 143 °C3 mm Hg(lit.)
Density 1.2031 (estimate)
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
pka 13.41±0.20(Predicted)
form powder to crystal
color White to Light yellow
BRN 2332258
InChI InChI=1S/C13H10F2O/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8,13,16H
InChIKey WCTZPQWLFWZYJE-UHFFFAOYSA-N
SMILES C(O)(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1
CAS DataBase Reference 365-24-2(CAS DataBase Reference)
NIST Chemistry Reference 4,4'-Difluorobenzhydrol(365-24-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36/37-26
WGK Germany  3
HazardClass  IRRITANT
HS Code  29062900
Storage Class 11 - Combustible Solids
NFPA 704
0
1 0

4,4'-Difluorobenzhydrol price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 222682 Bis(4-fluorophenyl)methanol 98% 365-24-2 5g $49.6 2026-04-30 Buy
TCI Chemical D1795 4,4'-Difluorobenzhydrol >98.0%(GC) 365-24-2 25g $54 2026-04-30 Buy
Apolloscientific PC2648 4,4'-Difluorobenzhydrol >98% 365-24-2 25g $21 2026-06-04 Buy
Apolloscientific PC2648 4,4'-Difluorobenzhydrol >98% 365-24-2 100g $36 2026-06-04 Buy
Apolloscientific PC2648 4,4'-Difluorobenzhydrol >98% 365-24-2 500g $154 2026-06-04 Buy
Product number Packaging Price Buy
222682 5g $49.6 Buy
D1795 25g $54 Buy
PC2648 25g $21 Buy
PC2648 100g $36 Buy
PC2648 500g $154 Buy

4,4'-Difluorobenzhydrol Chemical Properties,Uses,Production

Chemical Properties

white to yellowish crystalline flakes or powder

Uses

4-Chloropyridine-3-sulfonyl Chloride can be used for antiinflammatory properties.

General Description

Bis(4-fluorophenyl)methanol is one of the degardation product of flunarizine hydrochloride (FLZ).

Synthesis

Bis(4-fluorophenyl)-methanone

345-92-6

4,4'-Difluorobenzhydrol

365-24-2

GENERAL METHODS: NaBH4 (0.6 mol) was added batchwise to a stirred solution of 4,4'-difluorobenzophenone (1.0 mol) in methanol (2 volumes) at room temperature for 45 min. The reaction mixture was stirred at ambient temperature for 2-3 h (progress of the reaction was monitored by TLC), and upon completion of the reaction, the reaction was diluted with water (750 mL), the pH was adjusted to 4 with acetic acid, and the reaction was subsequently extracted with dichloromethane (2 x 400 mL). The organic layer was washed with water (200 mL), dried with anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give pure 4,4'-difluorodiphenylmethanol as a white to off-white solid in 93-97% yield. To a stirred solution of 4,4'-difluorodiphenylmethanol (1.0 mol) in toluene (370 mL) at room temperature was added concentrated hydrochloric acid (35% aqueous, 370 mL) and tetrabutylammonium bromide (0.01 mol). The mixture was continued to be stirred at 40-45 °C for 6-7 h. After TLC showed that the reaction was complete, the mixture was cooled to room temperature. The organic layer was separated and concentrated under vacuum to give crude 4,4'-difluorodiphenylmethyl chloride as a light brown liquid in 95-97% yield. Anhydrous piperazine (5.0 mol) was slowly added to a solution of 4,4'-difluorodiphenylmethyl chloride (0.96 mol) in toluene (380 mL) at 60-70 °C for 45-60 minutes. The resulting mixture was heated at 90-100°C for 8-10 hours with stirring. After completion of the reaction the mixture was cooled and water (380 mL) was added to separate the organic layer. The organic layer was washed with a 1:1 mixture of concentrated hydrochloric acid and water (2 x 350 mL) and subsequently neutralized with 20% NaOH solution (750 mL). The aqueous layer was again extracted with toluene (2×300 mL), and the organic layers were combined, dried with anhydrous sodium sulfate, and concentrated in vacuum to afford the pure 4,4'-difluorodiphenylmethylpiperazine derivative as a white to off-white solid in 88% yield.

References

[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 28, p. 5094 - 5096
[2] Synthesis, 2010, # 12, p. 1989 - 1991
[3] Synthetic Communications, 2014, vol. 44, # 5, p. 600 - 609
[4] Organic Letters, 2000, vol. 2, # 5, p. 659 - 661
[5] Patent: , 2016, . Location in patent: Paragraph 0016; 0018; 0019; 0020; 0021; 0022

4,4'-Difluorobenzhydrol Preparation Products And Raw materials

Raw materials

4-Fluorobenzeneboronic acid 4-Fluorobenzaldehyde Bis(4-fluorophenyl)-methanone Methyl formate 4-Bromofluorobenzene
4-Fluorobenzyl bromide Methanol Sodium borohydride

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Preparation Products

Benzene, 1,1'-[(2-chloroethoxy)methylene]bis[4-fluoro-

4,4'-Difluorobenzhydrol Suppliers

Global( 311)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangsu Derui Pharmaceutical Co., Ltd 0512-62620298 17037718886 18636423@qq.com China 18 58
Hubei SVETO New Material Technology Co., Ltd 13277095679 1375175909@qq.com China 641 58
Hubei Norna Technology Limited Company 59209883 17386169806 service@nornachem.com China 4829 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Supplier Advantage
Jiangsu Derui Pharmaceutical Co., Ltd 58
Hubei SVETO New Material Technology Co., Ltd 58
Hubei Norna Technology Limited Company 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64

View Lastest Price from 4,4'-Difluorobenzhydrol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,4'-Difluorobenzhydrol pictures 2026-05-28 4,4'-Difluorobenzhydrol
365-24-2
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
4,4'-Difluorobenzhydrol pictures 2025-05-23 4,4'-Difluorobenzhydrol
365-24-2
 $10.00 1kg 99% 20 ton Hebei Zhuanglai Chemical Trading Co Ltd
4,4'-Difluorobenzhydrol pictures 2024-06-18 4,4'-Difluorobenzhydrol
365-24-2
 $1.00 1KG 99% 20t Shaanxi Dideu Medichem Co. Ltd

4,4'-Difluorobenzhydrol Spectrum

4,4'-Difluorobenzhydrol(365-24-2)MS4,4'-Difluorobenzhydrol(365-24-2)1HNMR4,4'-Difluorobenzhydrol(365-24-2)13CNMR4,4'-Difluorobenzhydrol(365-24-2)IR14,4'-Difluorobenzhydrol(365-24-2)IR24,4'-Difluorobenzhydrol(365-24-2)Raman

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4,4'-DIFLUOROBENZYLMETHANOL 4,4-DIFLUOROBENZHYDROL Benzenemethanol, 4-fluoro-alpha-(4-fluorophenyl)- BIS-(4-FLUOROPHENYL)-CARBINOL BIS-(4-FLUOROPHENYL)-METHANOL LABOTEST-BB LT00233218 4,4'-difluorobenzhydryl alcohol 4,4-Difluorophenylmethanol Bis-(4-fluorophenyl)-methanol 4,4'-Difluorobenzhydrol, 98+% 4-chloropyridine-3-sulfonylchloride 4,4'-Difluorobenzhydrol 98% 4,4''-DIFLUOROPHENYLMETHANOL 4-CHLORO-3-PYRIDINESULFENYL CHLORIDE 4’4-Difluorobenzhydrd 4,4'-difluorodibenzohydrol 4,4''-DIFLUROBENZYLMETHANOL 2,4-pyridinediolC5H5NO2 4,4''-DIFLUOROBENZHYDROLFLUNARIZINE 4,4μ-Difluorobenzhydrol, Bis(4-fluorophenyl) carbinol Bis(4-fluorophenyl)methanol,4,4′-Difluorobenzhydrol, Bis(4-fluorophenyl) carbinol 4,4'-Difluorobenzhyd 4-Fluoro-α-(4-fluorophenyl)benzenemethanol α-(4-Fluorophenyl)-4-fluorobenzyl alcohol Alpha-9-Methyl-9-A2Abicyclo[3,3,1]Aonan-3-Amine Difluorodiphenylmethanol Flunarizine Impurity 8 Flunarizine Impurity 4 4,4'-Difluorobenzhydrol> Benzenemethanol, 4-fluoro-α-(4-fluorophenyl)- Benzenemethanol, 4-fluoro-a-(4-fluorophenyl)- 4,4'-Difluorobenzhydrol 4,4'-Diflurobenzylmethanol 4,4 '- p-difluorobenzyl alcohol 4,4'-difluorobenzhydrol, >98.0% 365-24-2 FC6H42CHOH C13H12F2O C13H10F2O C9 to C30 Alcohols Building Blocks Organic Building Blocks Oxygen Compounds Alcohols Aryl Fluorinated Building Blocks Building Blocks C11 to C30+ C13-C26 Chemical Synthesis Fluorinated Building Blocks Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Oxygen Compounds Benzhydrols, Benzyl & Special Alcohols