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ChemicalBook >> CAS DataBase List >>N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea

N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea

N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea Structure
N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea structure
CAS No.
228544-65-8
Chemical Name:
N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea
Synonyms
VULM 1457;1-(2,6-Diisopropylphenyl)-3-(4-((4-nitrophenyl)thio)phenyl)urea;N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea;Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]-;VULM 1457,acyl-CoA:cholesterol acyltransferase,hypercholesterolaemia,Diacylglycerol acyltransferase,ischaemia-reperfusion,myocardial,Diglyceride acyltransferase,mono- acylglycerol acyltransferase,Inhibitor,VULM1457,acyl-CoA,cholesterol acyltransferase,Acyltransferase,hypolipidaemic,inhibit,VULM-1457,diabetes mellitus
CBNumber:
CB42454335
Molecular Formula:
C25H27N3O3S
Molecular Weight:
449.57
MDL Number:
MFCD10687104
MOL File:
228544-65-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:40
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N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea Properties

Boiling point 535.0±50.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble to 100 mM in DMSO
form Powder
pka 13.79±0.70(Predicted)
color Light yellow to yellow

N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 257082 VULM 1457 Asreported 228544-65-8 10mg $446 2026-06-03 Buy
Usbiological 257082 VULM 1457 Asreported 228544-65-8 50mg $1160 2026-06-03 Buy
Biosynth DJA54465 VULM 1457 228544-65-8 5mg $250 2026-06-04 Buy
Biosynth DJA54465 VULM 1457 228544-65-8 10mg $323.9 2026-06-04 Buy
Biosynth DJA54465 VULM 1457 228544-65-8 25mg $607 2026-06-04 Buy
Product number Packaging Price Buy
257082 10mg $446 Buy
257082 50mg $1160 Buy
DJA54465 5mg $250 Buy
DJA54465 10mg $323.9 Buy
DJA54465 25mg $607 Buy

N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea Chemical Properties, Uses, Production

Uses

VULM 1457 is a cholesterol acyltransferase inhibitor.

Biological Activity

Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. Decreases cholesterol levels in the plasma and liver of diabetic-hypercholesterolaemic rats.

in vivo

VULM 1457 significantly reduces atherogenic activity in animal experimental atherosclerosis[1].
VULM 1457 protect the hearts of diabetic–hypercholesterolaemic rats against ischaemia/reperfusion injury in vivo[2].
VULM 1457 (50 mg/kg/day; administered as an admixture to the fat-cholesterol diet for 5 days) significantly decreases plasma total cholesterol levels (1.7±0.1 mM vs. 2.9±0.5 mM in diabetic–hypercholesterolaemic animals). The hypolipidaemic effect of VULM 1457 is also observed in the liver of DM-HCH rats (3.9±0.2 mg/g vs. 7.4±1.0 mg/g)[2].

Animal Model:Male Wistar rats (250-300 g body weight), fed a standard diet and tap water ad libitum[2]
Dosage:50 mg/kg/day
Administration:Administered as an admixture to the fat-cholesterol diet for 5 days
Result:Improved the overall myocardial ischaemia-reperfusion injury outcomes in the diabetic-hypercholesterolaemic rats by suppressing arrhythmogenesis as well as by reducing myocardial necrosis, aside from remarkable hypolipidaemic activity.

IC 50

ACAT

N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea Preparation Products And Raw materials

Raw materials

Preparation Products

N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea Suppliers

Global Suppliers ( 37)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
MQ (shanghai) Pharmaceuticals Co., Ltd. 13761635123 sales@linyuepharm.com China 5731 55
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8137 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 4999 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
MQ (shanghai) Pharmaceuticals Co., Ltd. 55
TargetMol Chemicals Inc. 58
MedBioPharmaceutical Technology Inc 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58

View Latest Price from N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-[2,6-BIS(1-METHYLETHYL)PHENYL]-N'-[4-[(4-NITROPHENYL)THIO]PHENYL]UREA pictures 2026-07-29 N-[2,6-BIS(1-METHYLETHYL)PHENYL]-N'-[4-[(4-NITROPHENYL)THIO]PHENYL]UREA
228544-65-8
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
VULM 1457 pictures 2026-05-11 VULM 1457
228544-65-8
 $41.00-133.00 99.92% 10g TargetMol Chemicals Inc.
  • VULM 1457 pictures
  • VULM 1457
    228544-65-8
  • $41.00-133.00
  • 99.92%
  • TargetMol Chemicals Inc.

N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea Spectrum

N-[2,6-BIS(1-METHYLETHYL)PHENYL]-N'-[4-[(4-NITROPHENYL)THIO]PHENYL]UREA(228544-65-8)1HNMR

228544-65-8 (N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea) Related Search:

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VULM 1457 VULM 1457,acyl-CoA:cholesterol acyltransferase,hypercholesterolaemia,Diacylglycerol acyltransferase,ischaemia-reperfusion,myocardial,Diglyceride acyltransferase,mono- acylglycerol acyltransferase,Inhibitor,VULM1457,acyl-CoA,cholesterol acyltransferase,Acyltransferase,hypolipidaemic,inhibit,VULM-1457,diabetes mellitus Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]- 1-(2,6-Diisopropylphenyl)-3-(4-((4-nitrophenyl)thio)phenyl)urea N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea 228544-65-8