N-[2,6-BIS(1-METHYLETHYL)PHENYL]-N'-[4-[(4-NITROPHENYL)THIO]PHENYL]UREA
![N-[2,6-BIS(1-METHYLETHYL)PHENYL]-N'-[4-[(4-NITROPHENYL)THIO]PHENYL]UREA Structure](CAS/GIF/228544-65-8.gif)
- CAS No.
- 228544-65-8
- Chemical Name:
- N-[2,6-BIS(1-METHYLETHYL)PHENYL]-N'-[4-[(4-NITROPHENYL)THIO]PHENYL]UREA
- Synonyms
- VULM 1457;1-(2,6-Diisopropylphenyl)-3-(4-((4-nitrophenyl)thio)phenyl)urea;N-[2,6-BIS(1-METHYLETHYL)PHENYL]-N'-[4-[(4-NITROPHENYL)THIO]PHENYL]UREA;Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]-;VULM 1457,acyl-CoA:cholesterol acyltransferase,hypercholesterolaemia,Diacylglycerol acyltransferase,ischaemia-reperfusion,myocardial,Diglyceride acyltransferase,mono- acylglycerol acyltransferase,Inhibitor,VULM1457,acyl-CoA,cholesterol acyltransferase,Acyltransferase,hypolipidaemic,inhibit,VULM-1457,diabetes mellitus
- CBNumber:
- CB42454335
- Molecular Formula:
- C25H27N3O3S
- Molecular Weight:
- 449.57
- MDL Number:
- MFCD10687104
- MOL File:
- 228544-65-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| VULM1457 ≥99%(HPLC) | 2988 | 10 | $187 |
| VULM1457 ≥99%(HPLC) | 2988 | 50 | $787 |
| VULM1457 | V797703 | 10mg | $180 |
| VULM 1457 | 257082 | 10mg | $446 |
| VULM1457 | V797703 | 50mg | $755 |
N-[2,6-BIS(1-METHYLETHYL)PHENYL]-N'-[4-[(4-NITROPHENYL)THIO]PHENYL]UREA price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 2988 | VULM1457 ≥99%(HPLC) | 228544-65-8 | 10 | $187 | 2021-12-16 | Buy |
| Tocris | 2988 | VULM1457 ≥99%(HPLC) | 228544-65-8 | 50 | $787 | 2021-12-16 | Buy |
| TRC | V797703 | VULM1457 | 228544-65-8 | 10mg | $180 | 2021-12-16 | Buy |
| Usbiological | 257082 | VULM 1457 | 228544-65-8 | 10mg | $446 | 2021-12-16 | Buy |
| TRC | V797703 | VULM1457 | 228544-65-8 | 50mg | $755 | 2021-12-16 | Buy |
N-[2,6-BIS(1-METHYLETHYL)PHENYL]-N'-[4-[(4-NITROPHENYL)THIO]PHENYL]UREA Chemical Properties,Uses,Production
Uses
VULM 1457 is a cholesterol acyltransferase inhibitor.
Biological Activity
Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. Decreases cholesterol levels in the plasma and liver of diabetic-hypercholesterolaemic rats.
in vivo
VULM 1457 significantly reduces atherogenic activity in animal experimental atherosclerosis[1].
VULM 1457 protect the hearts of diabetic–hypercholesterolaemic rats against ischaemia/reperfusion injury in vivo[2].
VULM 1457 (50 mg/kg/day; administered as an admixture to the fat-cholesterol diet for 5 days) significantly decreases plasma total cholesterol levels (1.7±0.1 mM vs. 2.9±0.5 mM in diabetic–hypercholesterolaemic animals). The hypolipidaemic effect of VULM 1457 is also observed in the liver of DM-HCH rats (3.9±0.2 mg/g vs. 7.4±1.0 mg/g)[2].
| Animal Model: | Male Wistar rats (250-300 g body weight), fed a standard diet and tap water ad libitum[2] |
| Dosage: | 50 mg/kg/day |
| Administration: | Administered as an admixture to the fat-cholesterol diet for 5 days |
| Result: | Improved the overall myocardial ischaemia-reperfusion injury outcomes in the diabetic-hypercholesterolaemic rats by suppressing arrhythmogenesis as well as by reducing myocardial necrosis, aside from remarkable hypolipidaemic activity. |
IC 50
ACAT
N-[2,6-BIS(1-METHYLETHYL)PHENYL]-N'-[4-[(4-NITROPHENYL)THIO]PHENYL]UREA Preparation Products And Raw materials
Raw materials
Preparation Products
N-[2,6-BIS(1-METHYLETHYL)PHENYL]-N'-[4-[(4-NITROPHENYL)THIO]PHENYL]UREA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 86249 | 60 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5562 | 55 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4887 | 58 |
