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ChemicalBook >> CAS DataBase List >>(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one

(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one

(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Structure
(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one structure
CAS No.
1523406-39-4
Chemical Name:
(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
Synonyms
SAR-405;CS-2552;SAR-405;SAR 405;SAR405, 10 mM in DMSO;VPS34 Inhibitor, SAR405;inhibit,Autophagy,Inhibitor,Phosphoinositide 3-kinase,SAR405,PI3K,SAR 405,SAR-405;(S)-1-((5-Chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydr;(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one;(8S)-9-[(5-chloropyridin-3-yl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-7,8-dihydro-6H-pyrimido[1,2-a]pyrimidin-4-one;(S)-9-((5-Chloropyridin-3-yl)methyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one
CBNumber:
CB42742375
Molecular Formula:
C19H21ClF3N5O2
Molecular Weight:
443.85
MDL Number:
MFCD28411361
MOL File:
1523406-39-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Properties

Boiling point 526.5±60.0 °C(Predicted)
Density 1.51±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥22.19 mg/mL in DMSO; insoluble in H2O; ≥32.25 mg/mL in EtOH with ultrasonic
form Powder
pka 3.29±0.20(Predicted)
color Off-white to light yellow
InChI 1S/C19H21ClF3N5O2/c1-12-11-30-5-4-26(12)16-7-17(29)27-3-2-15(19(21,22)23)28(18(27)25-16)10-13-6-14(20)9-24-8-13/h6-9,12,15H,2-5,10-11H2,1H3/t12-,15+/m1/s1
InChIKey SPDQRCUBFSRAFI-DOMZBBRYSA-N
SMILES FC(F)(F)[C@H]1N(c3[n]([c](cc(n3)N4[C@@H](COCC4)C)=O)CC1)Cc2cncc(c2)Cl
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  WGK 3
HS Code  2934999090
Storage Class 11 - Combustible Solids

(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16979 SAR405 ≥98% 1523406-39-4 500μg $51 2026-04-30 Buy
Cayman Chemical 16979 SAR405 ≥98% 1523406-39-4 1mg $92 2026-04-30 Buy
Cayman Chemical 16979 SAR405 ≥98% 1523406-39-4 5mg $179 2026-04-30 Buy
Biosynth YKC40639 SAR 405 1523406-39-4 25mg $1293.25 2026-06-05 Buy
Biosynth YKC40639 SAR 405 1523406-39-4 50mg $1799 2026-06-05 Buy
Product number Packaging Price Buy
16979 500μg $51 Buy
16979 1mg $92 Buy
16979 5mg $179 Buy
YKC40639 25mg $1293.25 Buy
YKC40639 50mg $1799 Buy

(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Chemical Properties, Uses, Production

Uses

SAR 405 is an anticancer agent and a phosphoinositide 3-kinase (PI3K) inhibitor.

Biological Activity

Cell permeable: yes', 'Primary Target
VPS34

IC 50

Vps34: 1.2 nM (IC50); Vps34: 1.5 nM (Kd); Autophagy

(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Suppliers

Global Suppliers ( 102)
Supplier Tel Email Country ProdList Advantage
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai Balmxy Pharmaceutical Co., Ltd 021-24206007 13764915196 sales@balmxy.com China 6959 55
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4858 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 28150 68
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 13761310616 39324283@qq.com China 1365 58
Supplier Advantage
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Balmxy Pharmaceutical Co., Ltd 55
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Amadis Chemical Company Limited 58
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 58

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Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SAR405 pictures 2026-07-27 SAR405
1523406-39-4
 $50.00-179.00 99.99% 10g TargetMol Chemicals Inc.
  • SAR405 pictures
  • SAR405
    1523406-39-4
  • $50.00-179.00
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(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Spectrum

(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one(1523406-39-4)MS

1523406-39-4 ((S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one) Related Search:

(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one SAR405 R enantiomer XL-388 OSI-027 REVERSINE
BML-275

1of2

SAR-405;SAR 405 CS-2552 4H-Pyrimido[1,2-a]pyrimidin-4-one, 9-[(5-chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-, (8S)- (S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one SAR-405 (S)-1-((5-Chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydr (8S)-9-[(5-Chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one (S)-9-((5-Chloropyridin-3-yl)methyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one inhibit,Autophagy,Inhibitor,Phosphoinositide 3-kinase,SAR405,PI3K,SAR 405,SAR-405 SAR405, 10 mM in DMSO VPS34 Inhibitor, SAR405 (8S)-9-[(5-chloropyridin-3-yl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-7,8-dihydro-6H-pyrimido[1,2-a]pyrimidin-4-one 1523406-39-4 C19H21ClF3N5O2