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2-AMINO-5-METHOXYBENZOTRIFLUORIDE

2-AMINO-5-METHOXYBENZOTRIFLUORIDE structure

CAS No.: 53903-49-4

Chemical Name:: 2-AMINO-5-METHOXYBENZOTRIFLUORIDE

Synonyms: -AMINO-5-METHOXYBENZOTRIFLUORIDE;2-Aamino-5-ethoxybenzotrifluoride;2-AMINO-5-METHOXYBENZOTRIFLUORIDE;4-AMINO-3-(TRIFLUOROMETHYL)ANISOLE;5-METHOXY-2-AMINE-BENZOTRIFLUORIDE;4-METHOXY-2-(TRIFLUOROMETHYL)ANILINE;2-Amino-5-methoxybenzotrifluoride98%;2-Amino-5-methoxybenzotrifluoride 98%;4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLAMINE;4-methoxy-2-(trifluoromethyl)benzenamine

CBNumber:: CB4281436

Molecular Formula:: C8H8F3NO

Molecular Weight:: 191.15

MDL Number:: MFCD04972660

MOL File:: 53903-49-4.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:51

Product description	Number	Pack Size	Price
4-Methoxy-2-(trifluoromethyl)aniline	M332205	100mg	$60
2-Amino-5-methoxybenzotrifluoride 98%	066905	25g	$118
2-Amino-5-methoxybenzotrifluoride 98%	PC2635	25g	$122
2-Amino-5-methoxybenzotrifluoride 98%	4830-3-X0	25g	$195
2-Amino-5-methoxybenzotrifluoride 98%	4830-3-X0	5G	$55
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2-AMINO-5-METHOXYBENZOTRIFLUORIDE Properties

Boiling point	234.5±40.0 °C(Predicted)
Density	1.280±0.06 g/cm3(Predicted)
refractive index	1.4960
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	2.06±0.10(Predicted)
Appearance	Colorless to light yellow Liquid
InChI	InChI=1S/C8H8F3NO/c1-13-5-2-3-7(12)6(4-5)8(9,10)11/h2-4H,12H2,1H3
InChIKey	BTRQZDUCUGJMPS-UHFFFAOYSA-N
SMILES	C1(N)=CC=C(OC)C=C1C(F)(F)F

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Warning

Hazard statements

H302-H311-H315-H319-H332-H373

Precautionary statements

P280h-P302+P352-P305+P351+P338-P309-P310

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39

RIDADR

2810

Hazard Note

Irritant

HazardClass

6.1

PackingGroup

Ⅲ

HS Code

2922498590

NFPA 704

	0
3		0

2-AMINO-5-METHOXYBENZOTRIFLUORIDE price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	M332205	4-Methoxy-2-(trifluoromethyl)aniline	53903-49-4	100mg	$60	2021-12-16	Buy
Matrix Scientific	066905	2-Amino-5-methoxybenzotrifluoride 98%	53903-49-4	25g	$118	2021-12-16	Buy
Apolloscientific	PC2635	2-Amino-5-methoxybenzotrifluoride 98%	53903-49-4	25g	$122	2021-12-16	Buy
SynQuest Laboratories	4830-3-X0	2-Amino-5-methoxybenzotrifluoride 98%	53903-49-4	25g	$195	2021-12-16	Buy
SynQuest Laboratories	4830-3-X0	2-Amino-5-methoxybenzotrifluoride 98%	53903-49-4	5G	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
M332205	100mg	$60	Buy
066905	25g	$118	Buy
PC2635	25g	$122	Buy
4830-3-X0	25g	$195	Buy
4830-3-X0	5G	$55	Buy

2-AMINO-5-METHOXYBENZOTRIFLUORIDE Chemical Properties,Uses,Production

Synthesis

4-METHOXY-1-NITRO-2-TRIFLUOROMETHYL-BENZENE

344-39-8

53903-49-4

The general procedure for the synthesis of 2-amino-5-methoxybenzotrifluoride from 3-trifluoromethyl-4-nitroanisole was as follows:(b) Preparation of 4-methoxy-2-(trifluoromethyl)aniline by amination of 4-methoxy-2-(trifluoromethyl)nitrobenzene: In a 300 mL stainless steel autoclave, 25.0 g (0.11 mol) of 4-methoxy-2-(trifluoromethyl) nitrobenzene was dissolved in 150 mL of 95% ethanol. After purging the reactor with nitrogen, 1.1 g of 5% palladium-carbon catalyst was added and the autoclave was sealed. After purging with nitrogen again, the reactor was charged with 60 psi (413 kPa) hydrogen and stirring was started. During the reaction, the temperature was maintained between 25°C and 30°C by intermittent ice bath cooling. After approximately 90 minutes, hydrogen absorption was stopped. The pressure in the autoclave is released, flushed with nitrogen and opened. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give 22 g (100% yield) of a light yellow oily product identified as 4-methoxy-2-(trifluoromethyl)aniline.1H NMR analysis gave the following results: (δ, CDCl3) 7.82 (dd, J = 2 and 9 Hz, 1H), 7.00 (d, J = 2 Hz, 1H), 6.48 (d, J = 9 Hz, 1H ), 3.87 (br s, 2H) and 3.60 (s, 3H). Mass spectral analysis showed (m/e) 191 (M+), 176, 156, 128 and 52. The product was used directly in subsequent steps without further purification.

References

[1] Patent: US4879398, 1989, A
[2] Patent: CN107793413, 2018, A. Location in patent: Paragraph 0150; 0151; 0154; 0155
[3] Tetrahedron Letters, 2004, vol. 45, # 26, p. 5131 - 5133
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 7, p. 2109 - 2118
[5] Patent: WO2005/47273, 2005, A1. Location in patent: Page/Page column 44

2-AMINO-5-METHOXYBENZOTRIFLUORIDE Preparation Products And Raw materials

Raw materials

4-METHOXY-1-NITRO-2-TRIFLUOROMETHYL-BENZENE 1-TrifluoroMethyl-1,2-benziodoxol-3(1H)-one p-Anisidine Ethanol Hydrogen

Nitrogen

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Preparation Products

2-AMINO-5-METHOXYBENZOTRIFLUORIDE Suppliers

Global( 96)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1061@dideu.com	China	3982	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3986	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30228	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Nanjing Dolon Biotechnology Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Fuxin Pharmaceutical	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Career Henan Chemica Co	58

View Lastest Price from 2-AMINO-5-METHOXYBENZOTRIFLUORIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-02-02	4-Methoxy-2-(trifluoromethyl)aniline 53903-49-4	US $0.00-0.00 / KG	10mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd

4-Methoxy-2-(trifluoromethyl)aniline
53903-49-4
US $0.00-0.00 / KG
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

2-AMINO-5-METHOXYBENZOTRIFLUORIDE Spectrum

2-AMINO-5-METHOXYBENZOTRIFLUORIDE(53903-49-4)¹HNMR

53903-49-4(2-AMINO-5-METHOXYBENZOTRIFLUORIDE)Related Search:

4-METHOXY-1-NITRO-2-TRIFLUOROMETHYL-BENZENE 3-AMINO-4-METHOXYBENZOTRIFLUORIDE,2-METHOXY-5-TRIFLUOROMETHYL-PHENYLAMINE 5-AMINO-2-METHOXYBENZOTRIFLUORIDE, 98+%,3-AMINO-6-METHOXYBENZOTRIFLUORIDE,5-AMINO-2-METHOXYBENZOTRIFLUORIDE,5-amino-2-methoxybenzotrifluoride,97 3-Amino-5-methoxybenzotrifluoride 97%,3-Amino-5-methoxybenzotrifluoride97%,3-AMINO-5-METHOXYBENZOTRIFLUORIDE,3-METHOXY-5-TRIFLUOROMETHYL-PHENYLAMINE N-(3-[4-AMINO-3-(TRIFLUOROMETHYL)PHENOXY]PHENYL)-N,N-DIMETHYLAMINE

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3-AMINO-2-METHOXYBENZOTRIFLUORIDE 3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-N-[4-(TRIFLUOROMETHYL)PHENYL]-2-THIOPHENECARBOXAMIDE 5H-Benzocyclohepten-7-amine, 6,7,8,9-tetrahydro-N,N-dimethyl-5-(4-nitr o-3- (trifluoromethyl)phenoxy)-, cis- N-(1,1-DIMETHYL-2-PROPYNYL)-3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-2-THIOPHENECARBOXAMIDE 4-(BENZYLOXY)-2-(TRIFLUOROMETHYL)ANILINE

METHYL 3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-2-THIOPHENECARBOXYLATE 3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-N-PHENYL-2-THIOPHENECARBOXAMIDE 2-METHOXY-5-AMINO-4-TRIFLUOMETHYL METHYL CARBOXYLATE

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2-AMINO-5-METHOXYBENZOTRIFLUORIDE 5-METHOXY-2-AMINE-BENZOTRIFLUORIDE 4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLAMINE 4-METHOXY-2-(TRIFLUOROMETHYL)ANILINE 2-Amino-5-methoxybenzotrifluoride 98% 2-Amino-5-methoxybenzotrifluoride98% 2-Aamino-5-ethoxybenzotrifluoride 4-Amino-3-(trifluoromethyl)anisole, 4-Methoxy-2-(trifluoromethyl)aniline 4-AMino-3-(trifluoroMethyl)anisole[2-AMino-5-Methoxybenzotrifluoride] 4-Amino-3-(trifluoromethyl)anisole[4-Methoxy-2-(trifluoromethyl)benzenamine(92%)] 4-AMINO-3-(TRIFLUOROMETHYL)ANISOLE -AMINO-5-METHOXYBENZOTRIFLUORIDE 4-methoxy-2-(trifluoromethyl)benzenamine Benzenamine, 4-methoxy-2-(trifluoromethyl)- 4-Methoxy-2-(trifluoromethyl)aniline,97% 53903-49-4 Fluorine series Aromatic Halides (substituted)