2-Methoxy-5-(trifluoromethyl)aniline
- CAS No.
- 349-65-5
- Chemical Name:
- 2-Methoxy-5-(trifluoromethyl)aniline
- Synonyms
- 3-AMINO-4-METHOXYBENZOTRIFLUORIDE;2-AMINO-4-TRIFLUOROMETHYLANISOLE;2-METHOXY-5-TRIFLUOROMETHYL-PHENYLAMINE;BUTTPARK 50\01-75;Telmovir impurity H;Letermovir Intermediate 2;5-trifluoromethyl-o-anisidine;2-METHOXY-5-(TRIFLUOROMETHYL)ANILINE;6-methoxy-α,α,α-trifluoro-m-toluidine;2-Methoxy-5-(trifluoromethyl)aniline>
- CBNumber:
- CB1277045
- Molecular Formula:
- C8H8F3NO
- Molecular Weight:
- 191.15
- MDL Number:
- MFCD00042486
- MOL File:
- 349-65-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Methoxy-5-(trifluoromethyl)aniline 96% | 336599 | 5g | $63.4 |
| 2-Methoxy-5-(trifluoromethyl)aniline >98.0%(GC)(T) | M2212 | 5g | $44 |
| 2-Methoxy-5-(trifluoromethyl)aniline >98.0%(GC)(T) | M2212 | 25g | $174 |
| 2-Methoxy-5-(trifluoromethyl)aniline Asreported | 283402 | 10g | $369 |
| 2-Methoxy-5-(trifluoromethyl)aniline Asreported | 283402 | 25g | $512 |
| More product size | |||
| Melting point | 58-60 °C (lit.) |
|---|---|
| Boiling point | 230.1±40.0 °C(Predicted) |
| Density | 1.2645 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 3.31±0.10(Predicted) |
| form | Crystalline Powder |
| color | Beige-gray to brown |
| BRN | 2835713 |
| InChI | InChI=1S/C8H8F3NO/c1-13-7-3-2-5(4-6(7)12)8(9,10)11/h2-4H,12H2,1H3 |
| InChIKey | RKUSRLUGUVDNKP-UHFFFAOYSA-N |
| SMILES | C1(N)=CC(C(F)(F)F)=CC=C1OC |
| CAS DataBase Reference | 349-65-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29222990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
2-Methoxy-5-(trifluoromethyl)aniline price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 336599 | 2-Methoxy-5-(trifluoromethyl)aniline 96% | 349-65-5 | 5g | $63.4 | 2023-06-20 | Buy |
| TCI Chemical | M2212 | 2-Methoxy-5-(trifluoromethyl)aniline >98.0%(GC)(T) | 349-65-5 | 5g | $44 | 2026-04-30 | Buy |
| TCI Chemical | M2212 | 2-Methoxy-5-(trifluoromethyl)aniline >98.0%(GC)(T) | 349-65-5 | 25g | $174 | 2026-04-30 | Buy |
| Usbiological | 283402 | 2-Methoxy-5-(trifluoromethyl)aniline Asreported | 349-65-5 | 10g | $369 | 2026-06-03 | Buy |
| Usbiological | 283402 | 2-Methoxy-5-(trifluoromethyl)aniline Asreported | 349-65-5 | 25g | $512 | 2026-06-03 | Buy |
2-Methoxy-5-(trifluoromethyl)aniline Chemical Properties,Uses,Production
Chemical Properties
Beige-greyish to brownish crystalline powder
Uses
2-Methoxy-5-(trifluoromethyl)aniline may be used in chemical synthesis.
Definition
ChEBI: 2-Methoxy-5-(trifluoromethyl)aniline is a member of (trifluoromethyl)benzenes.
Synthesis
394-25-2
349-65-5
Example 51 General procedure for the synthesis of 4-(8-methoxy-5-(trifluoromethyl)quinazolin-2-ylamino)phenyl)(morpholino)methanone (Compound 500) PP028218.0002: Step 1. Prepare a mixture of 2-methoxy-5-(trifluoromethyl)aniline A. A methanolic solution of 4-methoxy-3-nitrobenzotrifluoride and 10% Pd/C catalyst (10% loading) was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove the catalyst, and the filtrate was concentrated under reduced pressure and dried under vacuum to afford the target product 2-methoxy-5-(trifluoromethyl)aniline A in 99% yield as an off-white solid.ESI-MS m/z: 192.1 (MH+).
References
[1] Synthesis, 2006, # 19, p. 3316 - 3340
[2] Patent: WO2007/117607, 2007, A2. Location in patent: Page/Page column 363-364
[3] Journal of the American Chemical Society, 1952, vol. 74, p. 3011,3012
[4] Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1955, vol. 28, p. 969,972
[5] Chem.Abstr., 1956, p. 4880
2-Methoxy-5-(trifluoromethyl)aniline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; 19817745290 | bd@blocksynth.com | China | 5971 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1444 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 | marketing1@neostarunited.com | China | 8827 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29094 | 58 |
View Lastest Price from 2-Methoxy-5-(trifluoromethyl)aniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-08-26 | 2-Methoxy-5-(trifluoromethyl)aniline
349-65-5
|
$2.00-10.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 2-Methoxy-5-(trifluoromethyl)aniline
349-65-5
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-06-08 | 2-Methoxy-5-(trifluoromethyl)aniline | 1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. |
-
- 2-Methoxy-5-(trifluoromethyl)aniline
349-65-5
- $2.00-10.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Methoxy-5-(trifluoromethyl)aniline
349-65-5
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-Methoxy-5-(trifluoromethyl)aniline
- 99%
- Jinan Ruitong Biotech Co., Ltd.
