3-Methoxy-5-(trifluoromethyl)aniline
- CAS No.
- 349-55-3
- Chemical Name:
- 3-Methoxy-5-(trifluoromethyl)aniline
- Synonyms
- TIMTEC-BB SBB000295;5-TRIFLUOROMETHYL-M-ANISIDINE;3-Methoxy-5-(trifluoromethyl)anil;3-AMINO-5-METHOXYBENZOTRIFLUORIDE;3-METHOXY-5-(TRIFLUOROMETHYL)ANILINE;3-Amino-5-methoxybenzotrifluoride97%;5-methoxy-α,α,α-trifluoro-m-toluidine;3-Amino-5-methoxybenzotrifluoride 97%;3-METHOXY-5-TRIFLUOROMETHYL-PHENYLAMINE;3-Methoxy-5-(trifluoromethyl)aniline>
- CBNumber:
- CB3263886
- Molecular Formula:
- C8H8F3NO
- Molecular Weight:
- 191.15
- MDL Number:
- MFCD00000393
- MOL File:
- 349-55-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 50-52 °C (lit.) |
|---|---|
| Boiling point | 242.0±40.0 °C(Predicted) |
| Density | 1.280±0.06 g/cm3(Predicted) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 2.95±0.10(Predicted) |
| color | Light yellow to Brown |
| InChI | 1S/C8H8F3NO/c1-13-7-3-5(8(9,10)11)2-6(12)4-7/h2-4H,12H2,1H3 |
| InChIKey | VTFGJEYZCUWSAM-UHFFFAOYSA-N |
| SMILES | COc1cc(N)cc(c1)C(F)(F)F |
| CAS DataBase Reference | 349-55-3(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335-H302-H311-H332 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338-P280h-P309-P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38-23-22 | |||||||||
| Safety Statements | 26-37/39-24/25 | |||||||||
| RIDADR | PG3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 29222990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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3-Methoxy-5-(trifluoromethyl)aniline price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 196932 | 3-Methoxy-5-(trifluoromethyl)aniline 99% | 349-55-3 | 5g | $272 | 2023-01-07 | Buy |
| TCI Chemical | M2262 | 3-Methoxy-5-(trifluoromethyl)aniline >98.0%(GC)(T) | 349-55-3 | 1g | $63 | 2024-03-01 | Buy |
| TCI Chemical | M2262 | 3-Methoxy-5-(trifluoromethyl)aniline >98.0%(GC)(T) | 349-55-3 | 5g | $189 | 2024-03-01 | Buy |
| Biosynth | FM70659 | 3-Methoxy-5-(trifluoromethyl)aniline | 349-55-3 | 50g | $150 | 2026-06-04 | Buy |
| Biosynth | FM70659 | 3-Methoxy-5-(trifluoromethyl)aniline | 349-55-3 | 25g | $150 | 2026-06-04 | Buy |
3-Methoxy-5-(trifluoromethyl)aniline Chemical Properties, Uses, Production
Uses
3-Methoxy-5-(trifluoromethyl)aniline was used in the synthesis of spleen tyrosine kinase inhibitors based on the phenylamino pyrimidine thiazole.
Synthesis
328-79-0
349-55-3
General procedure for the synthesis of 3-methoxy-5-(trifluoromethyl)aniline from 3-nitro-5-(trifluoromethyl)anisole: 1-methoxy-3-nitro-5-(trifluoromethyl)benzene (8.50 g, 38.4 mmol) and 10% Pd/C catalyst (2.00 g, 1.88 mmol) were placed in methanol (40 mL), and the reaction was stirred at room temperature in a hydrogen atmosphere. The reaction was carried out for 24 hours. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to afford the title compound 3-methoxy-5-trifluoromethylaniline (7.2 g) as an orange solid. The product was analyzed by LC-MS (ESI): m/z [M+H]+ calculated value, retention time 1.56 min.
References
[1] Synthesis, 2006, # 19, p. 3316 - 3340
[2] Patent: US2005/54850, 2005, A1
[3] Journal of the Chemical Society, 1951, p. 2013,2016
[4] Journal of the American Chemical Society, 1955, vol. 77, p. 2284,2285
[5] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1977, p. 14 - 17
3-Methoxy-5-(trifluoromethyl)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan EnTai Technology Development Co,.Ltd | 86-27-82330560 | 2536851935@qq.com | China | 346 | 69 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1400 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 3-Methoxy-5-(trifluoromethyl)aniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-12 | 3-Methoxy-5-(trifluoromethyl)aniline
349-55-3
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 3-Methoxy-5-(trifluoromethyl)aniline
349-55-3
- $1.00
- 99%
- Career Henan Chemical Co
