2-[4-(4-Nitrophenyl)piperazino]-1-ethanol
![2-[4-(4-Nitrophenyl)piperazino]-1-ethanol Structure](CAS/GIF/5521-38-0.gif)
- CAS No.
- 5521-38-0
- Chemical Name:
- 2-[4-(4-Nitrophenyl)piperazino]-1-ethanol
- Synonyms
- 2-(4-(4-Nitrophenyl);1-Piperazineethanol, 4-(4-nitrophenyl)-;2-[4-(4-Nitrophenyl)piperazino]-1-ethanol;2-[4-(4-NITROPHENYL)PIPERAZIN-1-YL]ETHANOL;2-[4-(4-Nitrophenyl)-1-piperazinyl]ethanol;2-[4-(4-Nitrophenyl)-1-piperazinyl]ethanol,97%;2-[4-(4-Nitrophenyl)-1-piperazinyl]ethanol, 97%
- CBNumber:
- CB4286062
- Molecular Formula:
- C12H17N3O3
- Molecular Weight:
- 251.28
- MDL Number:
- MFCD00511837
- MOL File:
- 5521-38-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
2-[4-(4-Nitrophenyl)piperazino]-1-ethanol price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS42279 | 2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol 95% | 5521-38-0 | 1g | $108 | 2026-06-04 | Buy |
| Activate Scientific | AS42279 | 2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol 95% | 5521-38-0 | 5g | $340 | 2026-06-04 | Buy |
| Matrix Scientific | 044509 | 2-[4-(4-Nitrophenyl)piperazino]-1-ethanol | 5521-38-0 | 500.00mg | $39 | 2026-05-18 | Buy |
| Matrix Scientific | 044509 | 2-[4-(4-Nitrophenyl)piperazino]-1-ethanol | 5521-38-0 | 1.00g | $60 | 2026-05-18 | Buy |
| Matrix Scientific | 044509 | 2-[4-(4-Nitrophenyl)piperazino]-1-ethanol | 5521-38-0 | 5.00g | $200 | 2026-05-18 | Buy |
2-[4-(4-Nitrophenyl)piperazino]-1-ethanol Chemical Properties, Uses, Production
Synthesis
103-76-4
350-46-9
![2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL](/CAS/GIF/5521-38-0.gif)
5521-38-0
To a stirred suspension of anhydrous dimethyl sulfoxide (10 mL) of 1-fluoro-4-nitrobenzene (2 g, 14.17 mmol) and potassium carbonate (3.92 g, 28.3 mmol) was slowly added 2-(piperazin-1-yl)ethanol (2.089 mL, 17.01 mmol). The reaction mixture was heated and stirred at 80°C for 16 hours. After completion of the reaction, it was cooled to room temperature and the mixture was poured into water (100 mL) and extracted with ethyl acetate (30 mL). The aqueous layer was separated and a second extraction was performed with ethyl acetate (2 x 30 mL). All organic phases were combined and concentrated under reduced pressure to remove the solvent. The concentrated residue was ground in water (100 mL) to precipitate a solid. The solid product was collected by vacuum filtration and dried under vacuum with a stream of nitrogen for 16 h to afford the target compound 2-[4-(4-nitrophenyl)piperazine]-1-ethanol (3.45 g, 97% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.11 (d, 2H), 6.82 (d, 2H), 3.68 (t, 2H), 3.44 (t, 4H), 2.67 (t, 4H), 2.62 (t, 2H), 2.55 (br s, 1H).Results of the analysis by LCMS (Method C): retention time (RT) = 0.45 min, m/z = 252 [M + H]+.
References
[1] Patent: WO2015/92431, 2015, A1. Location in patent: Page/Page column 236
[2] Patent: WO2015/27222, 2015, A2. Location in patent: Paragraph 0322
[3] Patent: WO2012/59932, 2012, A1. Location in patent: Page/Page column 112-113
[4] Patent: WO2016/138527, 2016, A1. Location in patent: Paragraph 00212
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 7, p. 2371 - 2387
2-[4-(4-Nitrophenyl)piperazino]-1-ethanol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2-[4-(4-Nitrophenyl)piperazino]-1-ethanol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
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| Chengdu Research Accelerators Technology Co., Ltd. | 028-64353063 | reacchemical@163.com | China | 5243 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
