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4,6-Dimethyl-1,2-phenylenediamine

4,6-Dimethyl-1,2-phenylenediamine structure

CAS No.: 3171-45-7

Chemical Name:: 4,6-Dimethyl-1,2-phenylenediamine

Synonyms: 4,5-DIMETHYL-1,2-PHENYLENEDIAMINE;4,5-Dimethyl-ortho-phenylenediamine;4,5-Dimethyl-1,2-benzenediamine;4,5-DimethyL;4-flouro-2-nitro aniline;4,5-DIMETHYL-BENZENE-1,2-DIAMINE;4,5-DIAMINO-O-XYLENE;Methylcobalamin Impurity 1;2-AMINO-4,5-DIMETHYLANILINE;4,5-Dimethyl-2-amino-aniline

CBNumber:: CB4292911

Molecular Formula:: C8H12N2

Molecular Weight:: 136.19

MDL Number:: MFCD00007729

MOL File:: 3171-45-7.mol

MSDS File:: SDS

Last updated:2026-09-12 18:52:44

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4,6-Dimethyl-1,2-phenylenediamine Properties

Melting point	127-129 °C (lit.)
Boiling point	279.6±35.0 °C(Predicted)
Density	1.076±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	5.02±0.10(Predicted)
form	Crystalline Mass, Crystals or Chunks
color	White to yellow to brownish
Water Solubility	Slightly soluble in water.
Sensitive	Air & Light Sensitive
InChI	InChI=1S/C8H12N2/c1-5-3-7(9)8(10)4-6(5)2/h3-4H,9-10H2,1-2H3
InChIKey	XSZYBMMYQCYIPC-UHFFFAOYSA-N
SMILES	C1(N)=CC(C)=C(C)C=C1N
CAS DataBase Reference	3171-45-7(CAS DataBase Reference)
FDA UNII	1OJ9D3R6NH
EPA Substance Registry System	1,2-Benzenediamine, 4,5-dimethyl- (3171-45-7)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319-H302-H312-H332-H335

Precautionary statements

P304+P340-P305+P351+P338-P405-P501a-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38-36

Safety Statements

26-36

RIDADR

2811

WGK Germany

Hazard Note

Irritant

TSCA

TSCA listed

HazardClass

6.1(a)

PackingGroup

HS Code

29212900

Storage Class

11 - Combustible Solids

NFPA 704

	1
3		1

4,6-Dimethyl-1,2-phenylenediamine price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D176605	4,5-Dimethyl-1,2-phenylenediamine 98%	3171-45-7	5g	$128	2026-04-30	Buy
Sigma-Aldrich	D176605	4,5-Dimethyl-1,2-phenylenediamine 98%	3171-45-7	25g	$207	2026-04-30	Buy
TCI Chemical	D1083	4,5-Dimethyl-1,2-phenylenediamine >98.0%(HPLC)	3171-45-7	5g	$63	2026-04-30	Buy
TCI Chemical	D1083	4,5-Dimethyl-1,2-phenylenediamine >98.0%(HPLC)	3171-45-7	25g	$255	2026-04-30	Buy
Biosynth	FD07754	4,5-Dimethyl-1,2-phenylenediamine	3171-45-7	0.025kg	$150	2026-06-04	Buy

Product number	Packaging	Price	Buy
D176605	5g	$128	Buy
D176605	25g	$207	Buy
D1083	5g	$63	Buy
D1083	25g	$255	Buy
FD07754	0.025kg	$150	Buy

4,6-Dimethyl-1,2-phenylenediamine Chemical Properties, Uses, Production

Chemical Properties

White to light brown solid

Uses

4, 5-dimethyl-o-phenylenediamine used in the determination of aromatic aldehydes by high performance liquid chromatography after precolumn fluorescent derivatization. For the determination of vanillin.

Uses

Employed in the preparation of transition metal complexes1 and quinoxalinones.2

Synthesis Reference(s)

Tetrahedron Letters, 42, p. 2277, 2001 DOI: 10.1016/S0040-4039(01)00163-0

Synthesis

6972-71-0

3171-45-7

(4.1) The reducing system was prepared by adding 32 mL of deionized water to 72 mL of anhydrous ethanol solution containing 12.9 g (57.17 mmol; 9.5 eq.) of SnCl2-2H2O. Subsequently, 1 g (6.02 mmol; 1 eq.) of 4,5-dimethyl-2-nitroaniline was added in batches at room temperature and under inert atmosphere. The reaction mixture was heated to reflux for 1 h. The reaction process was monitored by thin layer chromatography (TLC) (unfolding agent: ethyl acetate). After completion of the reaction, it was cooled to room temperature and the reaction mixture was poured into 120 mL of water and neutralized with NaHCO3. The tin salts and NaHCO3 were removed by filtration through filter paper. the filtrate was extracted with dichloromethane (organic phase 1) and the residual solid was continuously extracted with dichloromethane through a Soxhlet extractor for 2 days. The dichloromethane phase after Soxhlet extraction was washed once with water (organic phase 2). Organic phases 1 and 2 were combined, dried over anhydrous MgSO4, filtered and concentrated. The crude product was purified by silica gel fast column chromatography (elution gradient: cyclohexane/ethyl acetate 2/8; pure ethyl acetate; ethyl acetate/methanol 95/5). The resulting target compound (No. cs 357-1) was an orange solid in quantitative yield. rf = 0.33 (ethyl acetate). 1H NMR (CDCl3, ppm): 2.12 (s, 6H, 2 x CH3); 6.52 (s, 2H, 2 x aromatic CH). 13C NMR (CDCl3, ppm): 18.99 (CH3); 118.64 (aromatic CH); 128.02 (quaternary carbon-CH3); 132.38 (quaternary carbon-N). Mass spectrum (MS): [M + H]+ m/z = 137.1; [M + Na]+ m/z = 159.1; [M + K]+ m/z = 175.2.

References

[1] Patent: WO2011/117830, 2011, A1. Location in patent: Page/Page column 20
[2] Chemistry - A European Journal, 2018, vol. 24, # 36, p. 8989 - 8993
[3] ChemCatChem, 2016, vol. 8, # 15, p. 2461 - 2465
[4] Biochemische Zeitschrift, 1956, vol. 327, p. 422,447
[5] Chemische Berichte, 1901, vol. 34, p. 2255

4,6-Dimethyl-1,2-phenylenediamine Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate Ethanol Diethyl ether Nitric acid Sodium hydroxide

3,4-Dimethylaniline Sulfuric acid 4,5-Dimethyl-2-nitroaniline Hydrochloric acid Water

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Preparation Products

Mecobalamin Impurity LUMICHROME 6,7-dimethyl-2,3-diphenylquinoxaline 1H-Benzimidazole-2-methanol,5,6-dimethyl-(9CI) 1H-Benzimidazole, 2-cyclopropyl-5,6-dimethyl-

4,6-Dimethyl-1,2-phenylenediamine Suppliers

Global Suppliers ( 226)

Supplier	Tel	Email	Country	ProdList	Advantage
Xiamen Ruiyuxin Biotechnology Co., Ltd	0598-5501589 15392323620	zmy@welikepharma.com	China	97	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Changzhou Huanling Chemical Co., Ltd.	89803005 18206112582	info@huanlingchem.com	China	983	68
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
Xiamen Ruiyuxin Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61
Beijing Ouhe Technology Co., Ltd	60
Changzhou Huanling Chemical Co., Ltd.	68
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64

View Latest Price from 4,6-Dimethyl-1,2-phenylenediamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	4,5-Dimethyl-1,2-phenylenediamine 3171-45-7	$30.00-296.00	25g	0.98	25kg	Shanghai UCHEM Inc.
2025-06-20	4,6-DIMETHYL-1,2-PHENYLENEDIAMINE 3171-45-7	$50.00	1kg	0.99	10000	Hebei Yanxi Chemical Co., Ltd.
2024-07-08	4,5-Dimethyl-1,2-benzenediamine 3171-45-7	$1.00	1Kg	98%	20T	Shaanxi Dideu Medichem Co. Ltd

4,5-Dimethyl-1,2-phenylenediamine
3171-45-7
$30.00-296.00
0.98
Shanghai UCHEM Inc.

4,6-DIMETHYL-1,2-PHENYLENEDIAMINE
3171-45-7
$50.00
0.99
Hebei Yanxi Chemical Co., Ltd.

4,5-Dimethyl-1,2-benzenediamine
3171-45-7
$1.00
98%
Shaanxi Dideu Medichem Co. Ltd

4,6-Dimethyl-1,2-phenylenediamine Spectrum

4,6-DIMETHYL-1,2-PHENYLENEDIAMINE(3171-45-7)MS 4,6-DIMETHYL-1,2-PHENYLENEDIAMINE(3171-45-7)¹HNMR 4,6-DIMETHYL-1,2-PHENYLENEDIAMINE(3171-45-7)¹³CNMR 4,6-DIMETHYL-1,2-PHENYLENEDIAMINE(3171-45-7)IR1 4,6-DIMETHYL-1,2-PHENYLENEDIAMINE(3171-45-7)IR2 4,6-DIMETHYL-1,2-PHENYLENEDIAMINE(3171-45-7)Raman

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1,2-Benzenediamine, 4,5-dimethyl- 4,5-Dimethyl-1,2-diaminobenzene 4,5-Dimethyl-1,2-phenylenediamine 98% 4,5-bis(methyl-d3)benzene-1,2-diamine 4,5-Dimethylbenzene-1,2-diamine 98% 4,5-dimethyl-2-benzenediamine 2-AMINO-4,5-DIMETHYLPHENYLAMINE 2-AMINO-4,5-DIMETHYLANILINE 4,5-DIAMINO-O-XYLENE 4,5-DIAMINO-1,2-DIMETHYLBENZENE 4,5-DIMETHYL-O-PHENYLENE DIAMINE 4,5-DIMETHYL-BENZENE-1,2-DIAMINE 1,2-DIMETHYL-4,5-DIAMINOBENZENE 4,5-DIMETHYL-1,2-PHENYLENEDIAMINE 95+% 1,2-DIAMINO-4,5-DIMETHYLBENZENE 1,2-DiaMino-4,5-diMethylbenzene[4,5-DiMethyl-1,2-phenylenediaMine] 4,5-Dimethyl-1,2-phenylenediamine,4,5-Diamino-o-xylene 4,5-Dimethyl-1,2-phenylenediamine >95.0%(T) 4,5-DiMethyl-o-phenylenediaMine Monohydrate, 98% 4,5-Diamino-o-xylene, 4,5-Dimethylphenylene-1,2-diamine 4,5-Dimethylbenzene-1,2-diamine 98+% Methylcobalamin Impurity 1 4,5-Dimethyl-1,2-phenylenediamine > 4,5-Dimethyl-1,2-phenylenediamine, 95%, for synthesis 4,6-DIMETHYL-1,2-PHENYLENEDIAMINE ISO 9001：2015 REACH Cyanocobalamin /Vitamin B12 Impurity 17 4,5-Dimethyl-2-amino-aniline 4,5-Dimethyl-1,2-benzenediamine 4,5-Dimethyl-ortho-phenylenediamine 4,5-DimethyL 4,5-DIMETHYL-1,2-PHENYLENEDIAMINE 4-flouro-2-nitro aniline 4,6-Dimethyl-1,2-phenylenediamine 3171-45-7 CH32C6H2NH22 AMINE Organic Building Blocks Nitrogen Compounds Polyamines Building Blocks Building Blocks Chemical Synthesis Nitrogen Compounds Organic Building Blocks Polyamines Anilines, Aromatic Amines and Nitro Compounds intermediate