5-Amino-1-N-methylindole
- CAS No.
- 102308-97-4
- Chemical Name:
- 5-Amino-1-N-methylindole
- Synonyms
- 1-METHYL-1H-INDOL-5-AMINE;5-Amino-1-methylindole;TIMTEC-BB SBB010309;1-methylindol-5-amine;5-AMINO-N-METHYLINDOLE;1-Methyl-5-aminoindole;5-Amino-1-N-methylindole;5-Amino-1-methyl-1H-indole;1-METHYL-1H-INDOL-5-YLAMINE;1H-Indol-5-aMine, 1-Methyl-
- CBNumber:
- CB4306926
- Molecular Formula:
- C9H10N2
- Molecular Weight:
- 146.19
- MDL Number:
- MFCD03839873
- MOL File:
- 102308-97-4.mol
- MSDS File:
- SDS
| Melting point | 102 °C |
|---|---|
| Boiling point | 143-144 °C(Press: 2 Torr) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly) |
| form | Solid |
| pka | 5.05±0.10(Predicted) |
| color | Black |
| InChI | 1S/C9H10N2/c1-11-5-4-7-6-8(10)2-3-9(7)11/h2-6H,10H2,1H3 |
| InChIKey | PGTSGPCXPIFQEL-UHFFFAOYSA-N |
| SMILES | Cn1ccc2cc(N)ccc12 |
| CAS DataBase Reference | 102308-97-4(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-36-22-20/21/22 | |||||||||
| Safety Statements | 36/37/39-26-22 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
|||||||||
| NFPA 704 |
|
5-Amino-1-N-methylindole price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS014563 | 5-amino-1-N-Methylindole AldrichCPR | 100 mg | $77.9 | 2026-04-30 | Buy | |
| Usbiological | 260072 | 5-Amino-1-N-methylindole Asreported | 102308-97-4 | 250mg | $360 | 2026-06-03 | Buy |
| Usbiological | 260072 | 5-Amino-1-N-methylindole Asreported | 102308-97-4 | 500mg | $496 | 2026-06-03 | Buy |
| Usbiological | 260072 | 5-Amino-1-N-methylindole Asreported | 102308-97-4 | 1g | $656 | 2026-06-03 | Buy |
| Usbiological | 260072 | 5-Amino-1-N-methylindole Asreported | 102308-97-4 | 2g | $907 | 2026-06-03 | Buy |
5-Amino-1-N-methylindole Chemical Properties, Uses, Production
Chemical Properties
Brown solid
Uses
5-Amino-1-N-methylindole (CAS# 102308-97-4) is an indole derivative and building block, used in the copper-catalyzed synthesis of sulfonamides.
Synthesis
29906-67-0
102308-97-4
The general procedure for the synthesis of 1-methyl-5-aminoindole using 1-methyl-5-nitroindole as starting material was as follows: 10% Pd/C catalyst (0.18 g/g by mass of the feedstock) was added to the feedstock solution (THF dosage of 54 mL/g of feedstock) dissolved in THF. The reaction flask was sealed and air was removed by vacuum. Subsequently, a hydrogen-filled balloon was attached to the flask. The reaction was stirred continuously at room temperature for 24 to 48 hours or monitored by TLC until the feedstock completely disappeared. Upon completion of the reaction, the mixture was filtered through diatomaceous earth. The filtrate was collected and the solvent was removed by rotary evaporation to give a brown solid product in 100% yield. The structure of the product was confirmed by 1H NMR (DMSO-d6) and 13C NMR (DMSO-d6): 1H NMR (DMSO-d6): δ 7.15-7.05 (m, 2H), 6.71 (dd, J = 3.0, 0.9 Hz, 1H), 6.57 (dd, J = 8.5, 2.1 Hz, 1H), 6.12 (dd, J = 3.0, 0.9 Hz, 1H), 3.67 (s, 3H); 13C NMR (DMSO-d6): δ 141.30, 131.12, 129.49, 129.44, 129.41, 112.31, 110.11, 104.21, 99.13, 32.86.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 1202 - 1213
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 10, p. 3531 - 3541
[3] New Journal of Chemistry, 2015, vol. 39, # 7, p. 5360 - 5365
[4] Patent: CN104163815, 2017, B. Location in patent: Paragraph 0065; 0066; 0068
[5] Patent: CN107163029, 2017, A. Location in patent: Paragraph 0049; 0053; 0054; 0055; 0056; 0057; 0058
5-Amino-1-N-methylindole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Xishaonian biotechnology co., ltd | 0711-3700636 18827410479 | xujin@boronicgroup.com | China | 50 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 |
View Latest Price from 5-Amino-1-N-methylindole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 5-AMINO-1-N-METHYLINDOLE
102308-97-4
|
$1.00 | 1G | 98% | 100kg | Career Henan Chemical Co |
-
- 5-AMINO-1-N-METHYLINDOLE
102308-97-4
- $1.00
- 98%
- Career Henan Chemical Co
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