TLR2-IN-C29
- CAS No.
- 363600-92-4
- Chemical Name:
- TLR2-IN-C29
- Synonyms
- R2-IN-C29;TLR2-IN-C29;C29;C 29;C-29;C29, 10 mM in DMSO;TLR2-IN-C29 (C29 );3-((2-Hydroxy-3-methoxybenzylidene)amino)-2-methylbenzoic acid;3-((2-hydroxy-3-methoxyisobenzyl)amino)-2-methylbenzenemacetic acid;Benzoic acid, 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-;C29,TLR2,Inhibitor,hTLR2/1,inhibit,C-29,Toll-like,Toll-like Receptor (TLR),hTLR2/6,C 29
- CBNumber:
- CB43168697
- Molecular Formula:
- C16H15NO4
- Molecular Weight:
- 285.3
- MDL Number:
- MOL File:
- 363600-92-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >192°C (dec.) |
|---|---|
| Boiling point | 505.7±50.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.01±0.10(Predicted) |
| color | Dark Orange |
| Stability | Moisture Sensitive |
| InChI | InChI=1S/C16H15NO4/c1-10-12(16(19)20)6-4-7-13(10)17-9-11-5-3-8-14(21-2)15(11)18/h3-9,18H,1-2H3,(H,19,20) |
| InChIKey | WTGMGRFVBFDHGQ-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=CC(N=CC2=CC=CC(OC)=C2O)=C1C |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
TLR2-IN-C29 price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3817 | TLR2-IN-C29 ≥98% (HPLC) | 363600-92-4 | 10mg | $109 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3817 | TLR2-IN-C29 ≥98% (HPLC) | 363600-92-4 | 50mg | $351 | 2026-04-30 | Buy |
| Cayman Chemical | 27029 | C29 ≥95% | 363600-92-4 | 1mg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 27029 | C29 ≥95% | 363600-92-4 | 5mg | $214 | 2026-04-30 | Buy |
| Cayman Chemical | 27029 | C29 ≥95% | 363600-92-4 | 10mg | $393 | 2026-04-30 | Buy |
TLR2-IN-C29 Chemical Properties, Uses, Production
Uses
TLR2-IN-29 is a inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages.
Biological Activity
TLR2-IN-C29 is a toll/IL-1 receptor resistance (TIR) domain BB loop-targeting, selective toll-like receptor 2 (TLR2) antagonist th at inhibits both human TLR2/1 and TLR2/6-mediated signaling (IC50 = 37.6/19.7 μM against 50 ng/mL Pam3CSK/Pam2CSK-induced reporter signal, respectively, using HEK293T TLR2/6 or TLR2/1 transfectants), while blocking only murine TLR2/1-, but not murine TLR2/6-, mediated signaling (1h 25-50 μM C29 treatment prior to 50 ng P3C/mL or 100 ng P2C/mL for 1h in murine macrophages), nor signaling induced by other TLR agonists and TNF-α.
IC 50
TLR2
TLR2-IN-C29 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Jirun Biomedical Technology Co., Ltd. | 0539-0539-8613587 17661611089 | 2639273505@qq.com | China | 237 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9783 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
View Latest Price from TLR2-IN-C29 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | C29
363600-92-4
|
$47.00-189.00 | 99.95% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-24 | TLR2-IN-C29
363600-92-4
|
$1.00 | 1g | 99% | 20kg | Career Henan Chemical Co |
-
- C29
363600-92-4
- $47.00-189.00
- 99.95%
- TargetMol Chemicals Inc.
-
- TLR2-IN-C29
363600-92-4
- $1.00
- 99%
- Career Henan Chemical Co
