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Trifluoroacetophenone

Trifluoroacetophenone structure

CAS No.: 434-45-7

Chemical Name:: Trifluoroacetophenone

Synonyms: 2,2,2-TRIFLUORO-1-PHENYLETHAN-1-ONE;2,2,2-TRIFLUOROACETOPHENONE;2,2,2-TRIFLUORO-1-PHENYLETHANONE;Trifluoromethyl phenyl ketone;NSC 42752;TRIFLUOROACETOPHENONE;TRIFLUOROACETYLBENZENE;2,2,2-Trifluoracetophenon;2,2,2-trifluroacetophenone;A,A,A-TRIFLUOROACETOPHENONE

CBNumber:: CB4322186

Molecular Formula:: C8H5F3O

Molecular Weight:: 174.12

MDL Number:: MFCD00000420

MOL File:: 434-45-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:42

Product description	Number	Pack Size	Price
2,2,2-Trifluoroacetophenone 99%	107840	5g	$54.7
2,2,2-Trifluoroacetophenone 99%	107840	25g	$260
2,2,2-Trifluoroacetophenone >98.0%(GC)	T0848	5g	$42
2,2,2-Trifluoroacetophenone >98.0%(GC)	T0848	25g	$123
2,2,2-Trifluoroacetophenone 99%	107840	100g	$567
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Trifluoroacetophenone Properties

Melting point	-40 °C
Boiling point	165-166 °C (lit.) 46-48 °C/14 mmHg (lit.)
Density	1.24 g/mL at 25 °C (lit.)
refractive index	n20/D 1.458(lit.)
Flash point	107 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Ethyl Acetate
form	Liquid
Specific Gravity	1.240
color	Clear colorless to yellow
Water Solubility	PRACTICALLY INSOLUBLE
BRN	1866286
InChI	1S/C8H5F3O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H
InChIKey	KZJRKRQSDZGHEC-UHFFFAOYSA-N
SMILES	FC(F)(F)C(=O)c1ccccc1
CAS DataBase Reference	434-45-7(CAS DataBase Reference)
FDA UNII	6T7L1UPY09
NIST Chemistry Reference	Ethanone, 2,2,2-trifluoro-1-phenyl-(434-45-7)
EPA Substance Registry System	Ethanone, 2,2,2-trifluoro-1-phenyl- (434-45-7)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Warning

Hazard statements

H226-H315-H319-H335

Precautionary statements

P210-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xi,F

Risk Statements

10-36/37/38

Safety Statements

26-36-37/39-16

RIDADR

UN 1224 3/PG 3

WGK Germany

Hazard Note

Corrosive/Lachrymatory

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29147090

Storage Class

3 - Flammable liquids

Hazard Classifications

Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3

Limited Quantities

1.0 L (0.3 gallon) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	2
2		0

Trifluoroacetophenone price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	107840	2,2,2-Trifluoroacetophenone 99%	434-45-7	5g	$54.7	2026-04-30	Buy
Sigma-Aldrich	107840	2,2,2-Trifluoroacetophenone 99%	434-45-7	25g	$260	2026-04-30	Buy
TCI Chemical	T0848	2,2,2-Trifluoroacetophenone >98.0%(GC)	434-45-7	5g	$42	2026-04-30	Buy
TCI Chemical	T0848	2,2,2-Trifluoroacetophenone >98.0%(GC)	434-45-7	25g	$123	2026-04-30	Buy
Sigma-Aldrich	107840	2,2,2-Trifluoroacetophenone 99%	434-45-7	100g	$567	2026-04-30	Buy

Product number	Packaging	Price	Buy
107840	5g	$54.7	Buy
107840	25g	$260	Buy
T0848	5g	$42	Buy
T0848	25g	$123	Buy
107840	100g	$567	Buy

Trifluoroacetophenone Chemical Properties,Uses,Production

Chemical Properties

CLEAR COLORLESS TO YELLOW LIQUID

Uses

2,2,2-Trifluoroacetophenone is a fluorinated acetophenone with inhibitory activity of acetylcholinesterase. 2,2,2-Trifluoroacetophenone was shown to have neuroprotective activity by inhibiting apoptosis in cerebellar granule neurons.

General Description

2,2,2-Trifluoroacetophenone is the starting material for the synthesis of f 3-trifluoromethyl-3-phenyldiazirine. It undergoes asymmetric reduction with optically active Grignard reagent to form 2,2,2-trifluoro-1-phenylethanol. It undergoes condensation with biphenyl, terphenyl, a mixture of biphenyl with terphenyl, phenyl ether and diphenoxybenzophenone to form new aromatic 3F polymers.

Synthesis

2,2,2-Trifluoroacetophenone is commonly synthesized by the following methods: (1) Trifluoroacetic acid is directly synthesized in one step by reacting directly with the Grignard reagent of bromobenzene. The yield is about 60%. The advantages of this method are simple operation and cheap raw materials. Disadvantages: exothermic and low yield. (2) in -40 , carbon disulfide solvent, the role of Lewis acid AlCl3, trifluoroacetic anhydride and the benzene ring to pay the acylation reaction preparation, yield of about 70%. Advantages of the method: one-step synthesis. Disadvantages: solvent toxicity, AlCl3 is difficult to deal with, the use of strong acid, strong alkali corrosion equipment and pollution of the environment. (3) Trifluoromethane gas and benzoate or benzoyl chloride reaction, preparation. Yield 70-80%.

Trifluoroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

2,2,2-TRIFLUORO-1-PHENYL-ETHYLAMINE (R)-(-)-ALPHA-(TRIFLUOROMETHYL)BENZYL ALCOHOL PHENYL TRIFLUOROACETATE (S)-(+)-ALPHA-(TRIFLUOROMETHYL)BENZYL ALCOHOL (R)-(+)-1-PHENYL-1-PROPANOL

3,3,3-trifluoro-2-phenyl-propanoic acid 4-METHOXY-3-BUTEN-2-ONE Ethyl L(-)-lactate Benzenemethanol, α-(nitromethyl)-α-(trifluoromethyl)-

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Trifluoroacetophenone Suppliers

Global( 364)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3590	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58

View Lastest Price from Trifluoroacetophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	Trifluoroacetophenone 434-45-7	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-12	Trifluoroacetophenone 434-45-7	US $1.00-100.00 / KG	1KG	99%	300KG	Shaanxi Dideu Medichem Co. Ltd
2025-04-15	Trifluoroacetophenone 434-45-7	US $10.00 / kg	1kg	99%	20ton	Hebei Zhuanglai Chemical Trading Co.,Ltd

Trifluoroacetophenone
434-45-7
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Trifluoroacetophenone
434-45-7
US $1.00-100.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

Trifluoroacetophenone
434-45-7
US $10.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

Trifluoroacetophenone Spectrum

Trifluoroacetophenone(434-45-7)MS Trifluoroacetophenone(434-45-7)¹HNMR Trifluoroacetophenone(434-45-7)IR1 Trifluoroacetophenone(434-45-7)IR2 Trifluoroacetophenone(434-45-7)Raman

434-45-7(Trifluoroacetophenone)Related Search:

3'-Fluoroacetophenone 3-Aminoacetophenone 4'-Hydroxyacetophenone 4-Fluoroacetophenone 2',4'-Dichloroacetophenone

Acetophenone 4-Nitroacetophenone 4'-Bromoacetophenone 2-Bromoacetophenone 3-Nitroacetophenone

4'-(Trifluoromethyl)acetophenone Trifluoroacetamide Trifluoroacetic acid Trifluoroacetic anhydride Trifluoroacetamidine

Trifluoroacetyl chloride 4'-METHYL-2,2,2-TRIFLUOROACETOPHENONE 4-Carboxy-alpha,alpha,alpha-trifluoroacetophenone

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α,α,α-Trifluoroacetophenone, Phenyl trifluoromethyl ketone 1-Phenyl-2,2,2-trifluoroethanone alpha,alpha,alpha-Trifluoroacetophenone,99% 2,2,2-Trifluoro-1-phenyl-1-ethanone 2,2,2-trifluroacetophenone NSC 42752 A,A,A-TRIFLUOROACETOPHENONE FOR SYNTHESI 1-Phenyl-2,2,2-trifluoroethan-1-one alpha,alpha,alpha-Trifluoroacetophenone, 99% 5GR a,a,a-Trifluoroacetophenone for synthesis A,A,A-TRIFLUOROACETOPHENONE ALPHA,ALPHA,ALPHA-TRIFLUOROACETOPHENONE 2,2,2-TRIFLUORO-1-PHENYLETHANONE 2,2,2-TRIFLUORO-1-PHENYLETHAN-1-ONE 2,2,2-TRIFLUOROACETOPHENONE 1,1,1-Trifluoroacetophenone Phenyl trifluoromethyl ketone~2,2,2-Trifluoroacetophenone alpha,alpha,alpha-Trifluoroacethophenone Ethanone, 2,2,2-trifluoro-1-phenyl- (9CI) Ethanone, 2,2,2-trifluoro-1-phenyl- 2,2,2-Trifluoroacetophenone 99% 2,2,2-Trifluoroacetophenone99% PHENYL TRIFLUOROMETHYL KETONE TRIFLUOROACETOPHENONE TRIFLUOROACETYLBENZENE 2,2,2-Trifluoro-1-phenylethanoate 2,2,2-trifluoro-1-phenyl-ethanon Acetophenone, 2,2,2-trifluoro- Ethanone, 1,1,1-trifluoro,2-phenyl- omega,omega,omega-Trifluoroacetophenone Trifluoromethyl phenyl ketone 2,2,2-Trifluoroacetophenone > 2,2,2-Trifluoroacetophenone, 99%, for synthesis 2,2,2-Trifluoro-1-Phenylethanone,98% 2,2,2-Trifluoracetophenon 2-Fluoro-4,6-dimethoxybenzoic acid Trifluoroacetophenone 2,2,2-trifluroacetophenone,Ethanone, 2,2,2-trifluoro-1-phenyl-,2,2,2-Trifluoro-1-Phenylethanone,PHENYL TRIFLUOROMETHYL 2,2,2-Trifluoroacetophenone, 98% α,α,α-Trifluorobenzophenone 434-45-7 CF3COC6H5 Building Blocks Carbonyl Compounds C7 to C8 Organic Building Blocks Ketones Aromatic Acetophenones & Derivatives (substituted) ketone ACETYLHALIDE