1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
![1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Structure](CAS/20180601/GIF/116409-29-1.gif)
- CAS No.
- 116409-29-1
- Chemical Name:
- 1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
- Synonyms
- NSC 370284;NSC 370284, 10 mM in DMSO;1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
- CBNumber:
- CB43282867
- Molecular Formula:
- C21H25NO6
- Molecular Weight:
- 387.43
- MDL Number:
- MOL File:
- 116409-29-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0083170 | NSC-370284 99.27% | 116409-29-1 | 5mg | $87 | 2026-06-04 | Buy |
| ChemScene | CS-0083170 | NSC-370284 99.27% | 116409-29-1 | 10mg | $162 | 2026-06-04 | Buy |
| ChemScene | CS-0083170 | NSC-370284 99.27% | 116409-29-1 | 25mg | $347 | 2026-06-04 | Buy |
| ChemScene | CS-0083170 | NSC-370284 99.27% | 116409-29-1 | 50mg | $585 | 2026-06-04 | Buy |
| ChemScene | CS-0083170 | NSC-370284 99.27% | 116409-29-1 | 100mg | $1018 | 2026-06-04 | Buy |
1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Chemical Properties, Uses, Production
Uses
NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5[1].
in vivo
NSC-370284 (2.5 mg/kg; i.p., once daily for 10 days) improves the pathological morphologies in peripheral blood (PB), bone marrow (BM), spleen, and liver tissues in MLL-AF9 acute myeloid leukemia (AML) mice model[1].
| Animal Model: | C57BL/6 (CD45.2) and B6.SJL (CD45.1) mice[1]. |
| Dosage: | 2.5mg/kg. |
| Administration: | Intraperitoneal injection, once daily, for 10 days. |
| Result: | Significantly inhibited MLL-AF9 induced AML in secondary bone marrow transplantation (BMT) recipient mice. |
IC 50
STAT3; STAT5; TET1
References
[1] Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099. DOI:10.1038/s41467-017-02290-w
1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Preparation Products And Raw materials
1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 17754423994 | candy@biochempartner.com | China | 3057 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| Wuhan Augda Biotechnology Co., Ltd | 15071299552 | 262933239@qq.com | China | 7201 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-88590548 18698872706 | 757984502@qq.com | China | 960 | 58 |
