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2-Amino-4-chloro-6-trifluoromethyl-pyrimidine

2-Amino-4-chloro-6-trifluoromethyl-pyrimidine Structure
2-Amino-4-chloro-6-trifluoromethyl-pyrimidine structure
CAS No.
16097-60-2
Chemical Name:
2-Amino-4-chloro-6-trifluoromethyl-pyrimidine
Synonyms
4-chloro-6-(trifluoromethyl)pyrimidin-2-amine;4-Chloro-6-(TrifluoroMethyl)-2-PyriMidinaMine;2-Amino-4-chloro-6-trifluoromethyl-pyrimidine;2-Pyrimidinamine, 4-chloro-6-(trifluoromethyl)-;4-CHLORO-6-(TRIFLUOROMETHYL)PYRIMIDIN-2-YLAMINE;PYRIMIDINE, 2-AMINO-4-CHLORO-6-(TRIFLUOROMETHYL)-;2-AMINO-4-CHLORO-6-TRIFLUOROMETHYL-PYRIMIDINE ISO 9001：2015 REACH
CBNumber:
CB4330741
Molecular Formula:
C5H3ClF3N3
Molecular Weight:
197.55
MDL Number:
MFCD06656426
MOL File:
16097-60-2.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:44
Request For Quotation

2-Amino-4-chloro-6-trifluoromethyl-pyrimidine Properties

Melting point 92-93 °C
Boiling point 280.7±50.0 °C(Predicted)
Density 1.598±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 0.29±0.10(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C5H3ClF3N3/c6-3-1-2(5(7,8)9)11-4(10)12-3/h1H,(H2,10,11,12)
InChIKey ZLIUVGFJXHOHLN-UHFFFAOYSA-N
SMILES C1(N)=NC(C(F)(F)F)=CC(Cl)=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933599590

2-Amino-4-chloro-6-trifluoromethyl-pyrimidine price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC904758 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine 99% 16097-60-2 250mg $21 2026-06-04 Buy
Apolloscientific PC904758 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine 99% 16097-60-2 1g $24 2026-06-04 Buy
Apolloscientific PC904758 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine 99% 16097-60-2 5g $48 2026-06-04 Buy
Apolloscientific PC904758 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine 99% 16097-60-2 25g $75 2026-06-04 Buy
Apolloscientific PC904758 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine 99% 16097-60-2 100g $297 2026-06-04 Buy
Product number Packaging Price Buy
PC904758 250mg $21 Buy
PC904758 1g $24 Buy
PC904758 5g $48 Buy
PC904758 25g $75 Buy
PC904758 100g $297 Buy

2-Amino-4-chloro-6-trifluoromethyl-pyrimidine Chemical Properties, Uses, Production

Synthesis

2-AMINO-4-HYDROXY-6-(TRIFLUOROMETHYL)PYRIMIDINE

1513-69-5

2-AMINO-4-CHLORO-6-TRIFLUOROMETHYL-PYRIMIDINE

16097-60-2

Example 15: Synthesis of 4-chloro-6-(trifluoromethyl)pyrimidin-2-amine (24) 2-Amino-6-(trifluoromethyl)pyrimidin-4-ol (200 mg, 1.1 mmol) was dissolved in a mixed solution of phosphorus oxychloride (POCl3, 3 eq., 0.3 mL, 3.3 mmol) and N,N-dimethylaniline (0.28 mL, 2 eq.). The reaction mixture was heated with stirring at 70 °C for 4 hours. Upon completion of the reaction, the mixture was slowly poured into an ice-water mixture to quench the reaction and the precipitated solid was collected by filtration to afford the target compound 24 in 59% yield. The product was identified by electrospray ionization mass spectrometry (ESI-MS), m/z 198 [M + H]+.

References

[1] Chinese Chemical Letters, 2013, vol. 24, # 5, p. 386 - 388
[2] Pesticide Science, 1999, vol. 55, # 5, p. 566 - 570
[3] Patent: WO2006/114409, 2006, A1. Location in patent: Page/Page column 23
[4] Patent: US2010/167935, 2010, A1. Location in patent: Page/Page column 24
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2429 - 2439

2-Amino-4-chloro-6-trifluoromethyl-pyrimidine synthesis

368-54-7
16097-60-2
Synthesis of 2-Amino-4-chloro-6-trifluoromethyl-pyrimidine from 4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol

2-Amino-4-chloro-6-trifluoromethyl-pyrimidine Preparation Products And Raw materials

Raw materials

4-Hydroxy-2-(methylthio)-6-(trifluoromethyl)pyrimidine 2-Amino-4-hydroxy-6-(trifluoromethyl)pyrimidine 4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol 6-(Trifluoromethyl)uracil

Preparation Products

2-Chloro-6-(trifluoromethyl)pyrimidin-4-amine

2-Amino-4-chloro-6-trifluoromethyl-pyrimidine Suppliers

Global Suppliers ( 70)
Supplier Tel Email Country ProdList Advantage
Nanjing YiFan Biological Technology Co., Ltd. 025-025-52700520 18914499889 sales@yfbiotech.com China 494 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Supplier Advantage
Nanjing YiFan Biological Technology Co., Ltd. 58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Capot Chemical Co., Ltd 66
Pure Chemistry Scientific Inc. 62
Adamas Reagent, Ltd. 59
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
China DongFan Chemical Co.,LTD 66
Shanghai Ennopharm Co., Ltd. 65
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57

View Latest Price from 2-Amino-4-chloro-6-trifluoromethyl-pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-AMINO-4-CHLORO-6-TRIFLUOROMETHYL-PYRIMIDINE pictures 2026-08-20 2-AMINO-4-CHLORO-6-TRIFLUOROMETHYL-PYRIMIDINE
16097-60-2
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-AMINO-4-CHLORO-6-TRIFLUOROMETHYL-PYRIMIDINE pictures 2020-01-09 2-AMINO-4-CHLORO-6-TRIFLUOROMETHYL-PYRIMIDINE
16097-60-2
 $1.00 1KG 99% 100KG Career Henan Chemical Co

2-Amino-4-chloro-6-trifluoromethyl-pyrimidine Spectrum

2-AMINO-4-CHLORO-6-TRIFLUOROMETHYL-PYRIMIDINE(16097-60-2)1HNMR

16097-60-2 (2-Amino-4-chloro-6-trifluoromethyl-pyrimidine) Related Search:

5-Amino-6-chloro-2-(trifluoromethyl)pyrimidine-4-thiol 2-Amino-4-chloro-6-trifluoromethyl-pyrimidine CHEMBRDG-BB 4015979 4-chloro-N-ethyl-6-(trifluoromethyl)-2-pyrimidinamine CHEMBRDG-BB 4015980
4-Chloro-6-trifluoromethylpyrimidine

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PYRIMIDINE, 2-AMINO-4-CHLORO-6-(TRIFLUOROMETHYL)- 4-CHLORO-6-(TRIFLUOROMETHYL)PYRIMIDIN-2-YLAMINE 4-Chloro-6-(TrifluoroMethyl)-2-PyriMidinaMine 4-chloro-6-(trifluoromethyl)pyrimidin-2-amine 2-Pyrimidinamine, 4-chloro-6-(trifluoromethyl)- 2-AMINO-4-CHLORO-6-TRIFLUOROMETHYL-PYRIMIDINE ISO 9001：2015 REACH 2-Amino-4-chloro-6-trifluoromethyl-pyrimidine 16097-60-2 C5H3ClF3N3 Fluorine series Building Blocks Pyrimidine