4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol
- CAS No.
- 368-54-7
- Chemical Name:
- 4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol
- Synonyms
- BUTTPARK 6\01-78;IFLAB-BB F2124-0845;4-HYDROXY-2-MERCAPTO-6-(TRIFLUO;6-(TRIFLUOROMETHYL)-2-THIOURACIL;URACIL, 2-THIO-6-(TRIFLUOROMETHYL)-;6-(trifluoromethyl)-2-mercaptopyrimidin-4-ol;2-MERCAPTO-6-(TRIFLUOROMETHYL)PYRIMIDIN-4-OL;2-SULFANYL-6-(TRIFLUOROMETHYL)-4-PYRIMIDINOL;2-sulfanyl-6-(trifluoroMethyl)pyriMidin-4-ol;2-Mercapto-6-(trifluoromethyl)-4-pyrimidinol
- CBNumber:
- CB7400681
- Molecular Formula:
- C5H3F3N2OS
- Molecular Weight:
- 196.15
- MDL Number:
- MFCD00112978
- MOL File:
- 368-54-7.mol
- MSDS File:
- SDS
| Melting point | 246-250 °C (lit.) |
|---|---|
| Density | 1.63±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Methanol |
| form | Powder |
| pka | 6.21±0.20(Predicted) |
| color | White to Almost white |
| λmax | 270nm(MeOH)(lit.) |
| InChI | 1S/C5H3F3N2OS/c6-5(7,8)2-1-3(11)10-4(12)9-2/h1H,(H2,9,10,11,12) |
| InChIKey | YZAOETRYQWFEOY-UHFFFAOYSA-N |
| SMILES | Oc1cc(nc(S)n1)C(F)(F)F |
| CAS DataBase Reference | 368-54-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Uracil, 2-thio-6-(trifluoromethyl)-(368-54-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 551821 | 4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol 97% | 368-54-7 | 1g | $49.8 | 2023-06-20 | Buy |
| TCI Chemical | M2739 | 2-Mercapto-6-(trifluoromethyl)-4-pyrimidinol >98.0%(HPLC)(T) | 368-54-7 | 1g | $47 | 2026-04-30 | Buy |
| TCI Chemical | M2739 | 2-Mercapto-6-(trifluoromethyl)-4-pyrimidinol >98.0%(HPLC)(T) | 368-54-7 | 5g | $173 | 2026-04-30 | Buy |
| Apolloscientific | PC9778 | 4-Hydroxy-2-thio-6-(trifluoromethyl)pyrimidine ≥95% | 368-54-7 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC9778 | 4-Hydroxy-2-thio-6-(trifluoromethyl)pyrimidine ≥95% | 368-54-7 | 5g | $54 | 2026-06-04 | Buy |
4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol Chemical Properties, Uses, Production
Uses
4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol is a pyrimidine derivative that can be used to prepare drugs for cancer treatment, antibacterial activity, antimalarial treatment, and arthritis treatment; it can also be used in the synthesis of herbicides, insecticides, and fungicides. For example, the antimalarial drug pyrimethamine, the antihypertensive drug minoxidil, the anticancer drug 5-fluorouracil, and the pesticide fungicides ethirimol and methylpyrimethanil all contain pyrimidine structures.
Uses
4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol (HTPT) can form a stable monolayer on the Au(111) surface.
General Description
4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol (HTPT) can form a stable monolayer on the Au(111) surface.
Synthesis
A 250mL three-necked flask equipped with mechanical stirring and a reflux condenser tube was charged with 27.6g (0.15 mol) ethyl trifluoroacetoacetate, 11.4g (0.15 mol) thiourea,100 mLDMF, heated to 120C, and the reaction was carried out for 4 hours. Cooling, decompression recovery of solvent, cooling precipitation of crystals, filtration, washed with water, the product 4-hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol 25.3g (yield: 86.0%).
4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-02 | 4-HYDROXY-6-(TRIFLUOROMETHYL)PYRIMIDINE-2-THIOL
368-54-7
|
$3.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 4-HYDROXY-6-(TRIFLUOROMETHYL)PYRIMIDINE-2-THIOL
368-54-7
- $3.00
- 98%
- Career Henan Chemical Co
