Naphazoline nitrate
- CAS No.
- 5144-52-5
- Chemical Name:
- Naphazoline nitrate
- Synonyms
- rinazin;Privina;naftizin;NaphazoL;naphtyzin;naphthisen;naphthizen;ine nitrate;privinenitrate;phazoline nitrate
- CBNumber:
- CB4336127
- Molecular Formula:
- C14H15N3O3
- Molecular Weight:
- 273.29
- MDL Number:
- MFCD00014316
- MOL File:
- 5144-52-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 167-170 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Sparingly soluble in water, soluble in ethanol (96 per cent). |
| form | Solid |
| color | White to off-white |
| Sensitive | Hygroscopic |
| BRN | 3779329 |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C14H14N2.HNO3/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;2-1(3)4/h1-7H,8-10H2,(H,15,16);(H,2,3,4) |
| InChIKey | ZAHXYMFVNNUHCP-UHFFFAOYSA-N |
| SMILES | C12C(C=CC=C1)=CC=CC=2CC1=NCCN1.[N+]([O-])(=O)O |
| CAS DataBase Reference | 5144-52-5(CAS DataBase Reference) |
| FDA UNII | SC99GR1T5S |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-36/37-60-36 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NJ4376000 | |||||||||
| F | 3-10 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29332900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
Naphazoline nitrate price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N0100000 | Naphazoline nitrate European Pharmacopoeia (EP) Reference Standard | 5144-52-5 | 10 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | N0100000 | Naphazoline nitrate European Pharmacopoeia (EP) Reference Standard | 5144-52-5 | n0100000 | $220 | 2024-03-01 | Buy |
| Usbiological | 285510 | Naphazoline nitrate Asreported | 5144-52-5 | 50g | $220 | 2026-06-03 | Buy |
| Usbiological | 285510 | Naphazoline nitrate Asreported | 5144-52-5 | 100g | $325 | 2026-06-03 | Buy |
| ChemScene | CS-0109389 | Naphazoline nitrate 99.12% | 5144-52-5 | 1g | $27 | 2026-06-04 | Buy |
Naphazoline nitrate Chemical Properties, Uses, Production
Chemical Properties
White or almost white, crystalline powder.
Uses
antihistamine
Indications
Naphazoline hydrochloride and naphazoline nitrate are white or almost white crystalline powders soluble 1 in 6 and 1 in 36 water, respectively. These are potent sympathomimetic vasoconstrictors with a direct alpha-adrenergic receptor stimulatory action, and may be used as topical decongestants in 0.05% or 0.1% eyedrops. Frequent application of these solutions will produce a reactive hyperaemia. Instillation should not be repeated in less than 4-6 hours to avoid this rebound congestion.
Naphazoline eyedrops cause slight mydriasis and are contra-indicated in patients with actual or suspected closed-angle glaucoma.
Although not administered systemically, topical application of naphazoline has resulted in systemic absorption, and it is readily absorbed from the gastro-intestinal tract (Martindale, 1977).
Definition
ChEBI: Naphazoline nitrate is a member of naphthalenes.
in vivo
Naphazoline nitrate (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF[1].
| Animal Model: | Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin))[1] |
| Dosage: | 0.2 mg/mL, 10 μl per eye |
| Administration: | Intraperitoneal injection (IP), once |
| Result: | Significantly suppressed conjunctival dye leakage in mice with histamine or antigeninduced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice. |
IC 50
IL-1β; IL-6; IL-4
Naphazoline nitrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yumen Qianhua Pharmaceutical Co., Ltd | 0519-82891186 18651213286 | tianhua@tianhuachem.com | China | 72 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6740 | 52 |
| Beijing Isomersyn Technology CO;LTD | 010-82954736 13391601435 | sales@isomersyn.com | China | 3294 | 57 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
View Latest Price from Naphazoline nitrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-19 | Naphazoline nitrate
5144-52-5
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-18 | Naphazoline nitrate
5144-52-5
|
1KG | 99%-101% By Titrimetry; BP | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-20 | Naphazoline nitrate
5144-52-5
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited |
-
- Naphazoline nitrate
5144-52-5
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Naphazoline nitrate
5144-52-5
- 99%-101% By Titrimetry; BP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Naphazoline nitrate
5144-52-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
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