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Naphazoline

Naphazoline structure

CAS No.: 835-31-4

Chemical Name:: Naphazoline

Synonyms: NAPHAZOLINE HCL;NAFAZOLINE;Naphazoline-d4;2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE;Antan;Imidin;Privine;Sanorin;Rhinazine;ciba2020/r

CBNumber:: CB2414016

Molecular Formula:: C14H14N2

Molecular Weight:: 210.27

MDL Number:: MFCD00066737

MOL File:: 835-31-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
Naphazoline 99.74%	CS-0034952	5mg	$54
Naphazoline 99.74%	CS-0034952	10mg	$76
Naphazoline 99.74%	CS-0034952	25mg	$125
Naphazoline 99.74%	CS-0034952	50mg	$181
Naphazoline 99.74%	CS-0034952	100mg	$269
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Naphazoline Properties

Melting point	254 °C
Boiling point	339.81°C (rough estimate)
Density	1.1063 (rough estimate)
refractive index	1.6180 (estimate)
storage temp.	2-8°C
pka	pKa 10.35 ± 0.02(H2O,t =25,Iundefined) (Uncertain)
form	Solid
color	White to light yellow
CAS DataBase Reference	835-31-4(CAS DataBase Reference)
EWG's Food Scores	1-3
FDA UNII	H231GF11BV
ATC code	R01AA08,R01AB02,S01GA01,S01GA51
NIST Chemistry Reference	Naphazoline(835-31-4)

SAFETY

Risk and Safety Statements

Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	NJ4375000
REACH Registrations	Inactive

Naphazoline price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0034952	Naphazoline 99.74%	835-31-4	5mg	$54	2026-06-04	Buy
ChemScene	CS-0034952	Naphazoline 99.74%	835-31-4	10mg	$76	2026-06-04	Buy
ChemScene	CS-0034952	Naphazoline 99.74%	835-31-4	25mg	$125	2026-06-04	Buy
ChemScene	CS-0034952	Naphazoline 99.74%	835-31-4	50mg	$181	2026-06-04	Buy
ChemScene	CS-0034952	Naphazoline 99.74%	835-31-4	100mg	$269	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0034952	5mg	$54	Buy
CS-0034952	10mg	$76	Buy
CS-0034952	25mg	$125	Buy
CS-0034952	50mg	$181	Buy
CS-0034952	100mg	$269	Buy

Naphazoline Chemical Properties,Uses,Production

Originator

Privine,Ciba,US,1942

Uses

Adrenergic (vasoconstrictor).

Uses

Naphazoline is used in severe rhinitis associated with colds, allergic reactions, and severe and chronic inflammatory conditions, in particular for inflammation of the antrum of Highmore as well as for stopping nosebleeds.

Definition

ChEBI: 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole is a member of naphthalenes.

Manufacturing Process

2.7 parts of naphthyl-(1)-acetiminoethylether hydrochloride of the formula (produced from naphthyl-(1)-acetonitrile and methanol) are dissolved in 12 parts of absolute alcohol. 1 part of ethylenediamine is then added and the whole is heated to gentle boiling while passing nitrogen through it and simultaneously stirring until ammonia escapes no longer. The alcohol is then distilled and the residue mixed with 40 parts of benzene and 1.8 parts of caustic potash. Stirring is continued for some time whereby the imidazoline base is dissolved in benzene. The benzene residue is recrystallized several times from toluene.

brand name

Albalon (Allergan); Nafazair (Bausch & Lomb); Nafazair (Pharmafair); Naphcon (Alcon); Opcon (Bausch & Lomb); Vasocon (Novartis).

Therapeutic Function

Nasal decongestant

Synthesis

Naphazoline, 2-(1-naphthylmethyl)-2-imidazoline (11.1.36), is synthesized from (1-naphthyl)acetonitrile, which upon reaction with ethanol transforms into iminoester (11.1.35), and undergoes further heterocyclization into the desired imidozoline derivative (11.1.36) upon reaction with ethylendiamine [40].

Synthesis_835-31-4

Naphazoline synthesis

Synthesis of Naphazoline from 1-Naphthaleneacetic acid and Ethylenediamine

Naphazoline Preparation Products And Raw materials

Raw materials

Methanol Ethanol Ethylenediamine 1-Naphthalenol, 4-methylbenzenesulfonate 1-Naphthylacetonitrile

ETHYLENE DIAMINE TOSYLATE ETHYLENEDIAMINE MONOHYDRATE 1-Naphthaleneacetic acid Monoethanolamine

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Preparation Products

N-(2-AMINOETHYL)-2-(1-NAPHTHYL)ACETAMIDE Naphazoline nitrate

Naphazoline Suppliers

Global( 114)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29792	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32466	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34563	58
AFINE CHEMICALS LIMITED	+86-571-85134551 +86-18958018566	info@afinechem.com	China	15079	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5997	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52704	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10457	58
Zhuoer Chemical Co., Ltd	02120970332;	sales@zhuoerchem.com	China	2904	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20000	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
AFINE CHEMICALS LIMITED	58
Wuhan Fortuna Chemical Co., Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
Zhuoer Chemical Co., Ltd	58
Alfa Chemistry	58

View Lastest Price from Naphazoline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-29	Naphazoline 835-31-4		1kg	99%	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-07-27	Naphazoline 835-31-4	$40.00-93.00		99.79%	10g	TargetMol Chemicals Inc.
2021-08-31	naphazoline 835-31-4	$50.00	1KG	99%	500tons/month	Hubei Aumei New Material Co., Ltd.

Naphazoline
835-31-4
99%
WUHAN FORTUNA CHEMICAL CO., LTD

Naphazoline
835-31-4
$40.00-93.00
99.79%
TargetMol Chemicals Inc.

naphazoline
835-31-4
$50.00
99%
Hubei Aumei New Material Co., Ltd.

Naphazoline Spectrum

Naphazoline(835-31-4)¹HNMR

835-31-4(Naphazoline)Related Search:

Dihydromyrcenol 2-Methylnaphthalene Tolazoline hydrochloride 1-Methylimidazole Oxymetazoline

Imidazole Oxymetazoline hydrochloride Naphazoline nitrate IMIDAZOLE HYDROCHLORIDE Naphazoline hydrochloride

NAPHAZOLINE HYDROCHLORIDE - REFERENCE SPECTRUM NAPHAZOLINE IMPURITY A Naphazoline NAPHAZOLINE HCL(USP)(COMING SOON)(P) NAPHAZOLINE (BASE)

Naphazoline HCL USP23 NAPHAZOLINE NITRATE REFERENCE SPECTRUM EPY(CRM STANDARD) NAPHAZOLINE HYDROCHLORIDE IMP. C (EP): (1-NAPHTHYL)ACETONITRILE MM(CRM STANDARD)

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4,5-DIHYDRO-2-(1-NAPHTHYLMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE 2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE 2-(1-NAPHTHYLMETHYL)IMIDAZOLINIUM CHLORIDE 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)- 2-(Naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole Naphazoline 2-(1-Naphtylmethyl)-2-imidazoline 2-(1-Naphtylmethyl)-4,5-dihydro-1H-imidazole 4,5-Dihydro-2-(1-naphtylmethyl)-1H-imidazole Naphazoline-d4 naphazoline:2-(naphthalen-1-ylmethyl)-4,5-dihydro-1h-IMIDAZOLE 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole 2-(1-Naphethylmethyl)-2-imidazoline 2-(1-naphthylmethyl)-2-imidazolin 2-(1-Naphthylmethyl)-2-imidazoline 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole 2-(alpha-Naphthylmethyl)-imidazoline 2-(Naphthyl-(1')-methyl)imidazolin 2-(naphthyl-(1’)-methyl)imidazolin 2-Imidazoline, 2-(1-naphthylmethyl)- 4,5-dihydro-2-(1-naphthalenylmethyl)-1h-imidazol alpha-Naphthylmethyl imidazoline alpha-naphthylmethylimidazoline Antan CIBA 2020/r ciba2020/r Imidin Naphthizine Privine Rhinazine Sanorin Naphazoline USP/EP/BP Naphazoline DISCONTINUED. Please see N343955 or N343950 Inhibitor,TNFR,Adrenergic Receptor,Naphazoline,vascular hyperpermeability,Interleukin Related,decongestive,vasoconstriction,Tumor Necrosis Factor Receptor,cytokines,VEGFR,Vascular endothelial growth factor receptor,inflammation,inhibit,Naphthazoline,TNF Receptor,Beta Receptor,conjunctivitis NAFAZOLINE NAPHAZOLINE HCL 835-31-4 550-99-2835-31-4 C14H14N2HCl alpha-adrenoceptor agonist; imidazoline receptor agonist; vasoconstrictor. API