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Naphazoline

Naphazoline Structure
Naphazoline structure
CAS No.
835-31-4
Chemical Name:
Naphazoline
Synonyms
NAPHAZOLINE HCL;NAFAZOLINE;Naphazoline-d4;2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE;Antan;Imidin;Privine;Sanorin;Rhinazine;ciba2020/r
CBNumber:
CB2414016
Molecular Formula:
C14H14N2
Molecular Weight:
210.27
MDL Number:
MFCD00066737
MOL File:
835-31-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Naphazoline Properties

Melting point 254 °C
Boiling point 339.81°C (rough estimate)
Density 1.1063 (rough estimate)
refractive index 1.6180 (estimate)
storage temp. 2-8°C
pka pKa 10.35 ± 0.02(H2O,t =25,Iundefined) (Uncertain)
form Solid
color White to light yellow
CAS DataBase Reference 835-31-4(CAS DataBase Reference)
EWG's Food Scores 1-3
FDA UNII H231GF11BV
ATC code R01AA08,R01AB02,S01GA01,S01GA51
NIST Chemistry Reference Naphazoline(835-31-4)

SAFETY

Risk and Safety Statements

Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  NJ4375000
REACH Registrations Inactive

Naphazoline price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0034952 Naphazoline 99.74% 835-31-4 5mg $54 2026-06-04 Buy
ChemScene CS-0034952 Naphazoline 99.74% 835-31-4 10mg $76 2026-06-04 Buy
ChemScene CS-0034952 Naphazoline 99.74% 835-31-4 25mg $125 2026-06-04 Buy
ChemScene CS-0034952 Naphazoline 99.74% 835-31-4 50mg $181 2026-06-04 Buy
ChemScene CS-0034952 Naphazoline 99.74% 835-31-4 100mg $269 2026-06-04 Buy
Product number Packaging Price Buy
CS-0034952 5mg $54 Buy
CS-0034952 10mg $76 Buy
CS-0034952 25mg $125 Buy
CS-0034952 50mg $181 Buy
CS-0034952 100mg $269 Buy

Naphazoline Chemical Properties, Uses, Production

Originator

Privine,Ciba,US,1942

Uses

Adrenergic (vasoconstrictor).

Uses

Naphazoline is used in severe rhinitis associated with colds, allergic reactions, and severe and chronic inflammatory conditions, in particular for inflammation of the antrum of Highmore as well as for stopping nosebleeds.

Definition

ChEBI: 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole is a member of naphthalenes.

Manufacturing Process

2.7 parts of naphthyl-(1)-acetiminoethylether hydrochloride of the formula (produced from naphthyl-(1)-acetonitrile and methanol) are dissolved in 12 parts of absolute alcohol. 1 part of ethylenediamine is then added and the whole is heated to gentle boiling while passing nitrogen through it and simultaneously stirring until ammonia escapes no longer. The alcohol is then distilled and the residue mixed with 40 parts of benzene and 1.8 parts of caustic potash. Stirring is continued for some time whereby the imidazoline base is dissolved in benzene. The benzene residue is recrystallized several times from toluene.

brand name

Albalon (Allergan); Nafazair (Bausch & Lomb); Nafazair (Pharmafair); Naphcon (Alcon); Opcon (Bausch & Lomb); Vasocon (Novartis).

Therapeutic Function

Nasal decongestant

Synthesis

Naphazoline, 2-(1-naphthylmethyl)-2-imidazoline (11.1.36), is synthesized from (1-naphthyl)acetonitrile, which upon reaction with ethanol transforms into iminoester (11.1.35), and undergoes further heterocyclization into the desired imidozoline derivative (11.1.36) upon reaction with ethylendiamine [40].

Synthesis_835-31-4

Naphazoline synthesis

86-87-3
107-15-3
835-31-4
Synthesis of Naphazoline from 1-Naphthaleneacetic acid and Ethylenediamine

Naphazoline Preparation Products And Raw materials

Raw materials

Methanol Ethanol Ethylenediamine 1-Naphthalenol, 4-methylbenzenesulfonate 1-Naphthylacetonitrile
Ethylene diamine tosylate Ethylenediamine monohydrate 1-Naphthaleneacetic acid Monoethanolamine

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Preparation Products

N-(2-Aminoethyl)-2-(1-naphthyl)acetamide Naphazoline nitrate

Naphazoline Suppliers

Global Suppliers ( 113)
Supplier Tel Email Country ProdList Advantage
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2110 70
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Nanjing Sunlida Biological Technology Co., Ltd. 025-57798810 18652991625 sales@sunlidabio.com China 3223 55
Shanghai Macklin Biochemical Co.,Ltd. 15221275939 15221275939 shenlinxing@macklin.cn China 15775 55
Shanghai Synchem Pharma Co., ltd 21-619849051-1 18521059765 synchempharma@aliyun.com China 4988 55
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai QianYan Bio-technology Co., Ltd 02781293128 orders@biochemsafebuy.com China 9904 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Guangdong wengjiang Chemical Reagent Co., Ltd. 0751-2886750 13927877953 3005811397@qq.com China 13282 58
Supplier Advantage
LGM Pharma 70
BOC Sciences 65
Nanjing Sunlida Biological Technology Co., Ltd. 55
Shanghai Macklin Biochemical Co.,Ltd. 55
Shanghai Synchem Pharma Co., ltd 55
BOC Sciences 65
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai QianYan Bio-technology Co., Ltd 55
Amadis Chemical Company Limited 58
Guangdong wengjiang Chemical Reagent Co., Ltd. 58

View Latest Price from Naphazoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Naphazoline pictures 2026-09-17 Naphazoline
835-31-4
 1kg 99% 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
Naphazoline pictures 2026-07-27 Naphazoline
835-31-4
 $40.00-93.00 99.79% 10g TargetMol Chemicals Inc.
naphazoline pictures 2021-08-31 naphazoline
835-31-4
 $50.00 1KG 99% 500tons/month Hubei Aumei New Material Co., Ltd.
  • Naphazoline pictures
  • Naphazoline
    835-31-4
  • $40.00-93.00
  • 99.79%
  • TargetMol Chemicals Inc.
  • naphazoline pictures
  • naphazoline
    835-31-4
  • $50.00
  • 99%
  • Hubei Aumei New Material Co., Ltd.

Naphazoline Spectrum

Naphazoline(835-31-4)1HNMR

835-31-4 (Naphazoline) Related Search:

Dihydromyrcenol 2-Methylnaphthalene Tolazoline hydrochloride 1-Methylimidazole Oxymetazoline
Imidazole Oxymetazoline hydrochloride Naphazoline nitrate Naphazoline hydrochloride Imidazole hydrochloride
NAPHAZOLINE IMPURITY A Naphazoline hydrochloride - reference spectrum Naphazoline NAPHAZOLINE HCL(USP)(COMING SOON)(P) NAPHAZOLINE (BASE)
Naphazoline HCL USP23 NAPHAZOLINE NITRATE REFERENCE SPECTRUM EPY(CRM STANDARD) Naphazoline hydrochloride imp. C (EP): (1-naphthyl)acetonitrile mm(CRM standard)

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4,5-DIHYDRO-2-(1-NAPHTHYLMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE 2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE 2-(1-NAPHTHYLMETHYL)IMIDAZOLINIUM CHLORIDE 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)- 2-(Naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole Naphazoline 2-(1-Naphtylmethyl)-2-imidazoline 2-(1-Naphtylmethyl)-4,5-dihydro-1H-imidazole 4,5-Dihydro-2-(1-naphtylmethyl)-1H-imidazole Naphazoline-d4 naphazoline:2-(naphthalen-1-ylmethyl)-4,5-dihydro-1h-IMIDAZOLE 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole 2-(1-Naphethylmethyl)-2-imidazoline 2-(1-naphthylmethyl)-2-imidazolin 2-(1-Naphthylmethyl)-2-imidazoline 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole 2-(alpha-Naphthylmethyl)-imidazoline 2-(Naphthyl-(1')-methyl)imidazolin 2-(naphthyl-(1’)-methyl)imidazolin 2-Imidazoline, 2-(1-naphthylmethyl)- 4,5-dihydro-2-(1-naphthalenylmethyl)-1h-imidazol alpha-Naphthylmethyl imidazoline alpha-naphthylmethylimidazoline Antan CIBA 2020/r ciba2020/r Imidin Naphthizine Privine Rhinazine Sanorin Naphazoline USP/EP/BP Naphazoline DISCONTINUED. Please see N343955 or N343950 Inhibitor,TNFR,Adrenergic Receptor,Naphazoline,vascular hyperpermeability,Interleukin Related,decongestive,vasoconstriction,Tumor Necrosis Factor Receptor,cytokines,VEGFR,Vascular endothelial growth factor receptor,inflammation,inhibit,Naphthazoline,TNF Receptor,Beta Receptor,conjunctivitis NAFAZOLINE NAPHAZOLINE HCL 835-31-4 550-99-2835-31-4 C14H14N2HCl alpha-adrenoceptor agonist; imidazoline receptor agonist; vasoconstrictor. API