L-655,708
- CAS No.
- 130477-52-0
- Chemical Name:
- L-655,708
- Synonyms
- MSD;L-655,708;L 655708,L655708;L-655708, 10 mM in DMSO;ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE;Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate;Ethyl (S)-7-methoxy-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate;11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester;(S)-ethyl 7-methoxy-9-oxo-11,12,13,13a- tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate;11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER
- CBNumber:
- CB4345633
- Molecular Formula:
- C18H19N3O4
- Molecular Weight:
- 341.36
- MDL Number:
- MFCD02684528
- MOL File:
- 130477-52-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| L-655,708 ≥98% (HPLC), powder | L9787 | 5mg | $145 |
| L-655,708 ≥98% (HPLC), powder | L9787 | 25mg | $576 |
| L-655,708 ≥98% | 30322 | 5mg | $117 |
| L-655,708 ≥98% | 30322 | 10mg | $184 |
| L-655,708 ≥98% | 30322 | 25mg | $343 |
| More product size | |||
| Melting point | 175-176 °C |
|---|---|
| Boiling point | 584.4±50.0 °C(Predicted) |
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | Desiccate at +4°C |
| solubility | DMSO: 6 mg/mL |
| form | powder |
| pka | 1.49±0.20(Predicted) |
| color | White to yellow |
| InChI | 1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1 |
| InChIKey | YKYOQIXTECBVBB-AWEZNQCLSA-N |
| SMILES | CCOC(=O)c1ncn2-c3ccc(OC)cc3C(=O)N4CCCC4c12 |
| FDA UNII | L4BX842T8C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
L-655,708 price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L9787 | L-655,708 ≥98% (HPLC), powder | 130477-52-0 | 5mg | $145 | 2026-04-30 | Buy |
| Sigma-Aldrich | L9787 | L-655,708 ≥98% (HPLC), powder | 130477-52-0 | 25mg | $576 | 2026-04-30 | Buy |
| Cayman Chemical | 30322 | L-655,708 ≥98% | 130477-52-0 | 5mg | $117 | 2026-04-30 | Buy |
| Cayman Chemical | 30322 | L-655,708 ≥98% | 130477-52-0 | 10mg | $184 | 2026-04-30 | Buy |
| Cayman Chemical | 30322 | L-655,708 ≥98% | 130477-52-0 | 25mg | $343 | 2026-04-30 | Buy |
L-655,708 Chemical Properties,Uses,Production
Uses
L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner.
Biological Activity
Potent, selective inverse agonist for the benzodiazepine site of GABA A receptors containing the α 5 subunit (K i = 0.45 nM). Displays 50-100-fold selectivity over GABA A receptors containing α 1, α 2, α 3 or α 6 subunits in combination with β 3 and γ 2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.
Biochem/physiol Actions
L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats.
in vivo
L-655708 at 0.7 mg/kg, administered intraperitoneally, would result in 60-70% occupancy of α5 GABAA receptors with limited binding to α1, α2, and α3 subunit-containing GABAA receptors and no significant off-target behavioral effects, such as sedation and motor impairment.
storage
Desiccate at +4°C
L-655,708 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 5994 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
