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4-Hydroxyestrone

4-Hydroxyestrone Structure
4-Hydroxyestrone structure
CAS No.
3131-23-5
Chemical Name:
4-Hydroxyestrone
Synonyms
4-OH-E1;4-Hydroxyestrone;Estrone Impurity 8;Estrone 4-Hydroxy Impurity;1,3,5(10)-ESTRATRIEN-3,4-DIOL-17-ONE;1,3,5[10]-ESTRATRIENE-3,4-DIOL-17-ONE;5(10)-trien-17-one,3,4-dihydroxy-estra-3;3,4-dihydroxyestra-1,3,5(10)-trien-17-one;3,4-DIHYDROXY-1,3,5[10]-ESTRATRIEN-17-ONE;3,4-Dihydroxyestra-1(10),2,4-triene-17-one
CBNumber:
CB4353324
Molecular Formula:
C18H22O3
Molecular Weight:
286.37
MDL Number:
MFCD00079358
MOL File:
3131-23-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:45
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4-Hydroxyestrone Properties

Melting point 260-263°C
Boiling point 468.2±45.0 °C(Predicted)
Density 1.241±0.06 g/cm3(Predicted)
Flash point 93 °C
storage temp. −20°C
solubility DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form Solid
pka 10.06±0.40(Predicted)
color Pale Yellow to Light Brown
InChI 1S/C18H22O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,19,21H,2-3,5,7-9H2,1H3/t11-,12-,14+,18+/m1/s1
InChIKey XQZVQQZZOVBNLU-QDTBLXIISA-N
SMILES [H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc4c(O)c(O)ccc24
FDA UNII 3MN57C55S2
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
RTECS  KG7749500
Storage Class 11 - Combustible Solids

4-Hydroxyestrone price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H6012 4-Hydroxyestrone ≥90% (HPLC) 3131-23-5 5mg $267 2026-04-30 Buy
Sigma-Aldrich H6012 4-Hydroxyestrone ≥90% (HPLC) 3131-23-5 25mg $1050 2026-04-30 Buy
Cayman Chemical 33696 4-hydroxy Estrone ≥95% 3131-23-5 1mg $63 2026-04-30 Buy
Cayman Chemical 33696 4-hydroxy Estrone ≥95% 3131-23-5 5mg $257 2026-04-30 Buy
Cayman Chemical 33696 4-hydroxy Estrone ≥95% 3131-23-5 10mg $454 2026-04-30 Buy
Product number Packaging Price Buy
H6012 5mg $267 Buy
H6012 25mg $1050 Buy
33696 1mg $63 Buy
33696 5mg $257 Buy
33696 10mg $454 Buy

4-Hydroxyestrone Chemical Properties, Uses, Production

Chemical Properties

Pale Yellow Solid

Uses

A metabolite of Estradiol.

Definition

ChEBI: A 4-hydroxy steroid that is estrone substituted by a hydroxy group at position 4.

Hazard

A reproductive hazard.

Biochem/physiol Actions

4-Hydroxyestrone is an endogenous estrogen metabolite, which exhibits a strong neuroprotective effect against oxidative damage. It also provides effective protection against kanic acid-induced hippocampal oxidative damage in rats when compared to 17β-estradiol. 4-Hydroxyestrone regulates the angiogenic process during corpus luteum formation. It might be involved in an increased risk of cancer. 4-Hydroxyestrone is found in the early and mid-luteal phases.

4-Hydroxyestrone Preparation Products And Raw materials

Raw materials

Preparation Products

4-Hydroxyestrone Suppliers

Global Suppliers ( 58)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Clearsynth Labs Limited +91-22-26355700 info@clearsynth.com India 9656 58
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shandong JunRui Pharmaceutical Co., Ltd. 0539-5636807 15762008972 ffeng813@163.com China 245 58
Aikon International Limited 025-58851090 13913916777 sales01@aikonchem.com China 15947 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 sales@rrkchem.com China 57336 58
Dayang Chem (Hangzhou) Co.,Ltd. +86-0571-88938639 17705817739 info@dycnchem.com China 52593 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Chemsky（shanghai）International Co.,Ltd. 50
Clearsynth Labs Limited 58
Quality Control Solutions Ltd. 56
Sigma-Aldrich 80
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shandong JunRui Pharmaceutical Co., Ltd. 58
Aikon International Limited 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
Dayang Chem (Hangzhou) Co.,Ltd. 58

View Latest Price from 4-Hydroxyestrone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-HYDROXYESTRONE pictures 2024-07-07 4-HYDROXYESTRONE
3131-23-5
 $1.00 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd

3131-23-5 (4-Hydroxyestrone) Related Search:

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2,4-Dibromo-16a-hydroxyestrone Hydroxyestrone 2-Hydroxyestrone 1,3,5(10)-Estratrien-2,3-diol-17-one 3-methyl ether 1,3,5[10]-Estratriene-3,16alpha-diol-17-one
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1,3,5(10)-Estratrien-3,4-diol-17-one 4-methyl ether 4-Methoxyestrone-1,2,16,16-d4 4-Hydroxyestrone-1,2,16,16-d4

1of4

1,3,5[10]-ESTRATRIENE-3,4-DIOL-17-ONE 1,3,5(10)-ESTRATRIEN-3,4-DIOL-17-ONE 3,4-DIHYDROXY-1,3,5[10]-ESTRATRIEN-17-ONE 3,4-dihydroxyestra-1,3,5(10)-trien-17-one 5(10)-trien-17-one,3,4-dihydroxy-estra-3 (9S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one Estrone 4-Hydroxy Impurity 3,4-Dihydroxy-1(10),2,4-estratriene-17-one 3,4-Dihydroxyestra-1(10),2,4-triene-17-one 4-OH-E1 Estra-1,3,5(10)-trien-17-one, 3,4-dihydroxy- Estrone Impurity 8 (8R,9S,13S,14S)-3,4-Dihydroxy-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one 4-Hydroxyestrone 3131-23-5 Various Metabolites and Impurities Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Steroids