2,6-Dimethylfluorobenzene
- CAS No.
- 443-88-9
- Chemical Name:
- 2,6-Dimethylfluorobenzene
- Synonyms
- 2-FLUORO-1,3-DIMETHYLBENZENE;2-FLUORO-M-XYLENE;Fluoroxylene3;FLUORO-M-XYLENE;2-Fluoro-m-xylene>2-Fluoro-m-xylene,98%;2,6-DIMETHYLFLUOROBENZENE;2,5-DIMETHYLFLUOROBENZENE;1-FLUORO-2,6-DIMETHYLBENZENE;1,3-dimethyl-2-fluorobenzene
- CBNumber:
- CB4367264
- Molecular Formula:
- C8H9F
- Molecular Weight:
- 124.16
- MDL Number:
- MFCD00039215
- MOL File:
- 443-88-9.mol
- MSDS File:
- SDS
| Boiling point | 147-148 °C(lit.) |
|---|---|
| Density | 0.988 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 87 °F |
| storage temp. | 2-8°C |
| form | liquid |
| color | Clear, colourless |
| Specific Gravity | 0.988 |
| Water Solubility | Not miscible or difficult to mix in water. |
| BRN | 1857413 |
| InChI | InChI=1S/C8H9F/c1-6-4-3-5-7(2)8(6)9/h3-5H,1-2H3 |
| InChIKey | JTAUTNBVFDTYTI-UHFFFAOYSA-N |
| SMILES | C1(C)=CC=CC(C)=C1F |
| CAS DataBase Reference | 443-88-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,6-Dimethylfluorobenzene(443-88-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226 | |||||||||
| Precautionary statements | P261-P210-P233-P240-P241+P242+P243-P280-P303+P361+P353-P370+P378-P403+P235-P501 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | F,Xn | |||||||||
| Risk Statements | 10 | |||||||||
| Safety Statements | 16 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Flammable | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29039990 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Flam. Liq. 3 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2,6-Dimethylfluorobenzene price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 452866 | 2-Fluoro-1,3-dimethylbenzene 97% | 443-88-9 | 5ml | $87.3 | 2023-06-20 | Buy |
| TCI Chemical | F0402 | 2-Fluoro-m-xylene >98.0%(GC) | 443-88-9 | 5g | $38 | 2026-04-30 | Buy |
| TCI Chemical | F0402 | 2-Fluoro-m-xylene >98.0%(GC) | 443-88-9 | 25g | $183 | 2026-04-30 | Buy |
| Biosynth | FF104388 | 2-Fluoro-1,3-dimethylbenzene | 443-88-9 | 10g | $150 | 2026-06-04 | Buy |
| Biosynth | FF104388 | 2-Fluoro-1,3-dimethylbenzene | 443-88-9 | 100g | $150 | 2026-06-04 | Buy |
2,6-Dimethylfluorobenzene Chemical Properties, Uses, Production
Chemical Properties
Colorless liquid
Uses
It is used in the spectroscopic observation of jet-cooled 2-fluoro-m-xylyl radical.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 21, p. 906, 1978 DOI: 10.1021/jm00207a013
Synthesis
87-62-7
443-88-9
Example 2: General procedure for synthesizing 2-fluoro-1,3-dimethylbenzene from 2,6-dimethylaniline The diazotization of 2,6-dimethylaniline (2.3 g, 0.02 mol) was carried out in an Et3N-3HF system under the same conditions as for 2,4,6-trimethylaniline in Example 1. Upon initial addition of sodium nitrite (2.0 g, 0.03 mol), the color of the reaction mixture gradually changed from yellow to red. A small amount of tar is generated during the reaction, which can be easily separated by solvent extraction. The post-treatment was consistent with the description of 2,4,6-trimethylaniline. The organic layer was extracted from the aqueous phase using diethyl ether (150 mL), and the organic extract was dried over magnesium sulfate and fractionated by solvent to give an orange colored oil. The oily substance was distilled at 141-143 °C and atmospheric pressure to give the colorless liquid 1-fluoro-2,6-dimethylbenzene (2.0 g, 86.3% yield). The distillation process was completed in 1 hour. The 1H NMR (CDCl3) spectrum of the product showed: δ 2.25 (2-CH3 and 6-CH3, d, J = 2.0 Hz, 6H); δ 6.91 (3-H and 5-H, dd, J = 8.3 Hz and J = 6.5 Hz, 2H); and δ 7.01 (4-H, t, J = 8.0 Hz, 1H).19F NMR (CDCl3) spectrum was found to be at δ 122.5 (1-F, ts, J = 6.5 Hz and J = 2.0 Hz) showed signals. Mass spectrometry analysis showed the molecular ion peak at m/z 124 and characteristic fragmentation peaks of 1-fluoro-2,6-dimethylbenzene were observed at m/z 109, 103, 96, 89, 83 and 77.
References
[1] Patent: US6179970, 2001, B2
[2] Journal of the American Chemical Society, 1992, vol. 114, # 7, p. 2482 - 2494
[3] Proceedings - Indian Academy of Sciences, Section A, 1959, vol. 50, p. 51,56, 58, 59
[4] Journal of Medicinal Chemistry, 1978, vol. 21, # 9, p. 906 - 913
[5] Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1995, vol. 50, # 7, p. 1075 - 1078
2,6-Dimethylfluorobenzene Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| WUHAN JIXINYIBANG BIOTECHNOLOGY .,LTD | 59768661 13297943853 | 1704244976@qq.com | China | 4975 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 2,6-Dimethylfluorobenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-15 | 2,6-dimethylfluorobenzene
443-88-9
|
$20.00 | 1ASSAYS | 99% | 200MT/ year | Speranza Chemical Co., Ltd.
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2026-09-02 | 2,6-Dimethylfluorobenzene
443-88-9
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-03-20 | 2,6-Dimethylfluorobenzene
443-88-9
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 2,6-dimethylfluorobenzene
443-88-9
- $20.00
- 99%
- Speranza Chemical Co., Ltd.
-
- 2,6-Dimethylfluorobenzene
443-88-9
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2,6-Dimethylfluorobenzene
443-88-9
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
