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4-Aminotetrahydropyran

4-Aminotetrahydropyran structure

CAS No.: 38041-19-9

Chemical Name:: 4-Aminotetrahydropyran

Synonyms: TETRAHYDRO-2H-PYRAN-4-AMINE;oxan-4-amine;TETRAHYDRO-PYRAN-4-YLAMINE;4-Aminotetrahyropyran;4-AMINOTETRAHYDROPYRAN;Tetrahydropyran-4-amine;Noe Marioni, M.D., PLLC;4-Aminotetrahydro-2H-pyran;4-Aminotetrahydropyran?New;2H-PYRAN-4-AMINE, TETRAHYDRO-

CBNumber:: CB4376785

Molecular Formula:: C5H11NO

Molecular Weight:: 101.15

MDL Number:: MFCD02179436

MOL File:: 38041-19-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:35:38

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4-Aminotetrahydropyran Properties

Boiling point	60 °C
Density	0.977 g/cm3 at 25 °C
refractive index	n20/D 1.463
Flash point	54°C
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
pka	9.63±0.20(Predicted)
form	liquid
color	Colourless
InChI	InChI=1S/C5H11NO/c6-5-1-3-7-4-2-5/h5H,1-4,6H2
InChIKey	AHVQYHFYQWKUKB-UHFFFAOYSA-N
SMILES	C1OCCC(N)C1
CAS DataBase Reference	38041-19-9(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS07

Signal word

Danger

Hazard statements

H226-H302-H318

Precautionary statements

P210-P233-P240-P280-P301+P312-P305+P351+P338

Hazard Codes

Xi,Xn

Risk Statements

10-34-41-22-37/18

Safety Statements

16-26-36/37/39-39

RIDADR

2734

WGK Germany

HazardClass

IRRITANT

PackingGroup

Ⅲ

HS Code

29321900

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3

NFPA 704

	1
2		0

4-Aminotetrahydropyran price More Price(63)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	711357	4-Aminotetrahydropyran 97%	38041-19-9	1g	$167	2026-04-30	Buy
TCI Chemical	A2060	Tetrahydro-2H-pyran-4-amine min. 95.0 %	38041-19-9	5G	$65	2026-04-30	Buy
TCI Chemical	A2060	Tetrahydro-2H-pyran-4-amine min. 95.0 %	38041-19-9	25G	$213	2026-04-30	Buy
Biosynth	FA50769	4-Aminotetrahydropyran	38041-19-9	25g	$275	2026-06-04	Buy
Biosynth	FA50769	4-Aminotetrahydropyran	38041-19-9	50g	$412.5	2026-06-04	Buy

Product number	Packaging	Price	Buy
711357	1g	$167	Buy
A2060	5G	$65	Buy
A2060	25G	$213	Buy
FA50769	25g	$275	Buy
FA50769	50g	$412.5	Buy

4-Aminotetrahydropyran Chemical Properties,Uses,Production

Description

4-Aminotetrahydropyran contains the tetrahydropyran ring, which is the most frequently reported three-dimensional ring system in marketed drugs, and is second only to the phenyl ring when two-dimensional rings are included. It can be used as reactant/reagent in synthesis of aminothiazole compounds for use in treatment of cancer. Its scaffold is very useful in the drug discovery for cancer treatment.

Application

4-Aminotetrahydropyran can be used as reactant/reagent in synthesis of aminothiazole compounds for use in treatment of cancer.

Synthesis

61128-73-2

38041-19-9

General procedure for the synthesis of 4-aminotetrahydropyran from dihydro-2H-pyran-4(3H)-one oxime: Raney Ni (10%) was added to a stirred solution of compound 2.2 (1.0 g, 8.7 mmol) in methanol (50 mL) and the resulting mixture was stirred for 5 hr at room temperature in a hydrogen atmosphere. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the catalyst was removed by filtration and the methanol solvent in the filtrate was concentrated in vacuum to afford the target product 4-aminotetrahydropyran (Compound 2.3, 0.5 g, 57% yield).

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 7, p. 2210 - 2221
[2] Patent: US2009/82423, 2009, A1. Location in patent: Page/Page column 23
[3] Patent: US5707989, 1998, A
[4] Patent: US5821240, 1998, A
[5] Patent: US5977102, 1999, A

4-Aminotetrahydropyran synthesis

Synthesis of 4-Aminotetrahydropyran from Tetrahydro-4H-pyran-4-one

4-Aminotetrahydropyran Preparation Products And Raw materials

Raw materials

Ammonium formate Tetrahydro-4H-pyran-4-one Palladium N-Benzhydryl-tetrahydro-2H-pyran-4-amine di(tetrahydropyran-4-yl)amine

Tetrahydro-pyran-4-yl)-hydrazine Tetrahydro-pyran-4-one oxime Tetrahydro-2H-pyran-4-carboxamide Tetrahydro-4-pyranol Tetrahydro-2H-pyran-4-carboxylic acid

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Preparation Products

4-Aminotetrahydropyran hydrochloride

4-Aminotetrahydropyran Suppliers

Global( 375)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ITIC MEDCHEM(SUZHOU) CO.,LTD.	0512-68323967 18015559028	sales@iticmedchem.com	China	528	61
BTC Pharmaceutical CO. Ltd	+86-15716293042 15716293042	info@btcpharm.com	China	823	55
Shanghai Feixia Med-Pharm Technology Co., Ltd	008621-64224915 13301627320	Huangniml@163.com	China	19	55
Jinan Kabotang Biological Technology Co.,Ltd.	0531-61320525 15866703830	figo.gao@foxmail.com	China	7601	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66

Supplier	Advantage
ITIC MEDCHEM(SUZHOU) CO.,LTD.	61
BTC Pharmaceutical CO. Ltd	55
Shanghai Feixia Med-Pharm Technology Co., Ltd	55
Jinan Kabotang Biological Technology Co.,Ltd.	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
ShangHai DEMO Chemical Co.,Ltd	57
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66

View Lastest Price from 4-Aminotetrahydropyran manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	4-Aminotetrahydropyran 38041-19-9		1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-02	4-Aminotetrahydropyran 38041-19-9	$1.50-31.00	1kg	99%		Henan Fengda Chemical Co., Ltd
2026-08-20	4-Aminotetrahydropyran 38041-19-9	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited

4-Aminotetrahydropyran
38041-19-9
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

4-Aminotetrahydropyran
38041-19-9
$1.50-31.00
99%
Henan Fengda Chemical Co., Ltd

4-Aminotetrahydropyran
38041-19-9
$1.10
99.00%
Dideu Industries Group Limited

4-Aminotetrahydropyran Spectrum

4-Aminotetrahydropyran(38041-19-9)¹HNMR 4-Aminotetrahydropyran(38041-19-9)FT-IR

38041-19-9(4-Aminotetrahydropyran)Related Search:

Tetrahydro-2H-pyran-4-carboxylic acid Tetrahydropyran Centchroman Tetrahydro-4H-pyran-4-one 4-AMINOTETRAHYDROPYRAN, HCL,4-AMINOTETRAHYDROPYRAN HYDROCHLORIDE,4-AMINOTETRAHYDROPYRAN HYDROCHLORIDE (TETRAHYDRO-2H-PYRAN-4-AMINE HYDROCHLORIDE)

tetrahydropyran-4,4-dicarboxylic acid Tetrahydropyran-4-carbaldehyde Tetrahydropyran-4-boronic acid pinacol ester 4,4,5,5-Tetramethyl-2-(tetrahydro-2H-pyran-3-yl)-1,3,2-dioxaborolane Aminoacetonitrile hydrogen sulfate

Tetrahydro-pyran-3-ylamine hydrochloride Tetrahydro-pyran-4-carboxylic acid methylamide Gentamicin MEPARTRICIN Geneticin

Kanamycin A Nystatin Adriamycin

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