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Tetrahydro-4-pyranol

Tetrahydro-4-pyranol Structure
Tetrahydro-4-pyranol structure
CAS No.
2081-44-9
Chemical Name:
Tetrahydro-4-pyranol
Synonyms
TETRAHYDRO-2H-PYRAN-4-OL;Tetrahydropyran-4-ol;Oxan-4-ol;TETRAHYDRO-4H-PYRAN-4-OL;POH;Tetrahydropyranol;4-HYDROXYTETRAHYDROPYRAN;2H-Pyran-4-ol;4-HYDROXYTETRAHYDROPYAN;Tetrahydro-4-pranol
CBNumber:
CB0747105
Molecular Formula:
C5H10O2
Molecular Weight:
102.13
MDL Number:
MFCD00006633
MOL File:
2081-44-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:54:05
Product description Number Pack Size Price
Tetrahydro-4-pyranol 98% 198234 5g $155
Tetrahydro-4-pyranol 98% 198234 1g $44.4
Tetrahydro-4-pyranol >97.0%(GC) T2825 1g $18
Tetrahydro-4-pyranol >97.0%(GC) T2825 5g $25
4-Hydroxytetrahydropyan Asreported 279769 5g $442
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Tetrahydro-4-pyranol Properties

Boiling point 87 °C/15 mmHg (lit.)
Density 1.071 g/mL at 25 °C (lit.)
refractive index n20/D 1.462(lit.)
Flash point 190 °F
storage temp. Sealed in dry,Room Temperature
solubility Chloroform, Methanol
form Oil
pka 14.61±0.20(Predicted)
color Clear Colourless
BRN 102736
InChI InChI=1S/C5H10O2/c6-5-1-3-7-4-2-5/h5-6H,1-4H2
InChIKey LMYJGUNNJIDROI-UHFFFAOYSA-N
SMILES C1OCCC(O)C1
LogP -0.440 (est)
CAS DataBase Reference 2081-44-9(CAS DataBase Reference)
FDA UNII ZZ9W8N9YQV
NIST Chemistry Reference Tetrahydro-4H-pyran-4-ol(2081-44-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,Xn
Risk Statements  41-36/37/38-20/22
Safety Statements  26-39-36/37/39-23
RIDADR  1993
WGK Germany  3
HazardClass  IRRITANT
HS Code  29329990
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Dam. 1
REACH Registrations Active
NFPA 704
1
2 0

Tetrahydro-4-pyranol price More Price(108)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 198234 Tetrahydro-4-pyranol 98% 2081-44-9 5g $155 2026-04-30 Buy
Sigma-Aldrich 198234 Tetrahydro-4-pyranol 98% 2081-44-9 1g $44.4 2023-06-20 Buy
TCI Chemical T2825 Tetrahydro-4-pyranol >97.0%(GC) 2081-44-9 1g $18 2026-04-30 Buy
TCI Chemical T2825 Tetrahydro-4-pyranol >97.0%(GC) 2081-44-9 5g $25 2026-04-30 Buy
Usbiological 279769 4-Hydroxytetrahydropyan Asreported 2081-44-9 5g $442 2026-06-03 Buy
Product number Packaging Price Buy
198234 5g $155 Buy
198234 1g $44.4 Buy
T2825 1g $18 Buy
T2825 5g $25 Buy
279769 5g $442 Buy

Tetrahydro-4-pyranol Chemical Properties,Uses,Production

Chemical Properties

Colorless transparent liquid

Uses

Tetrahydro-4-pyranol (4-Hydroxytetrahydropyran) was used in the quantitative analysis of 3-hydroxytetrahydropyran (3-HTHP).

Uses

Tetrahydro-4-pyranol is a building block of various organic compounds and pharmaceuticals.

Synthesis

Tetrahydro-4H-pyran-4-one

29943-42-8

Tetrahydro-4-pyranol

2081-44-9

General procedure for the synthesis of tetrahydropyran-4-ol from tetrahydropyranone: To a tetrahydrofuran (THF, 25 mL) solution of tetrahydropyranone (5.0 g, 50 mmol), which was cooled to 0 °C, a THF (50 mL) suspension of lithium aluminum hydride (LiAlH4, 3.8 g, 0.1 mol) was slowly added. The reaction mixture was stirred at 0 °C for 30 min, followed by sequential addition of water (3.8 mL), 15% aqueous sodium hydroxide (NaOH) solution (3.8 mL) and water (11.4 mL) to quench the reaction. The mixture was filtered and the solid was washed with ethyl acetate (70 mL x 2). The filtrates were combined and evaporated to give tetrahydropyran-4-ol (5.09 g, 99% yield).

References

[1] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 39
[2] Patent: US9301951, 2016, B2. Location in patent: Page/Page column 125
[3] Chemistry - A European Journal, 2018, vol. 24, # 62, p. 16526 - 16531
[4] Patent: US2010/76029, 2010, A1. Location in patent: Page/Page column 35
[5] Patent: US2011/71196, 2011, A1. Location in patent: Page/Page column 18-19

Tetrahydro-4-pyranol synthesis

29943-42-8
2081-44-9
Synthesis of Tetrahydro-4-pyranol from Tetrahydro-4H-pyran-4-one

Tetrahydro-4-pyranol Preparation Products And Raw materials

Raw materials

Ethylene Phosphoric acid Sodium phosphate monobasic Aluminum chloride Tetrahydrofuran
Diethyl ether Lithium Aluminum Hydride Hydrochloric acid Dichloromethane Sodium hydroxide
3-Chloropropionyl chloride Magnesium sulfate

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Preparation Products

4-BROMO-TETRAHYDROPYRAN 1-(Tetrahydro-2H-pyran-4-yl)hydrazine Tetrahydropyran-4-carbaldehyde 2-(tetrahydro-2H-pyran-4-yloxy)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 4-IODOTETRAHYDRO-2H-PYRAN
Tetrahydropyranyl-4-acetic acid 3-Pyridinol, 5-chloro-6-[(tetrahydro-2H-pyran-4-yl)oxy]-

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Tetrahydro-4-pyranol Suppliers

Global( 329)Suppliers
Supplier Tel Email Country ProdList Advantage
BTC Nantong Pharmaceuticals Technology Co.,Ltd
+86-0513-81283365 Info@btcpharm.com China 251 58
BTC pharm India
+918790379245 banny.janga@btcpharm.com India 1262 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20121 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14026 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21585 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
Supplier Advantage
BTC Nantong Pharmaceuticals Technology Co.,Ltd
58
BTC pharm India
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Nanjing Finetech Chemical Co., Ltd. 		55

View Lastest Price from Tetrahydro-4-pyranol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tetrahydro-4-pyranol pictures 2026-07-20 Tetrahydro-4-pyranol
2081-44-9
 1KG 99%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
Tetrahydro-4-pyranol pictures 2026-07-20 Tetrahydro-4-pyranol
2081-44-9
 1KG ≥98% 100mt/year Jinan Finer Chemical Co., Ltd
Tetrahydro-4-pyranol pictures 2026-07-09 Tetrahydro-4-pyranol
2081-44-9
 $1.50-31.00 1kg 99% Henan Fengda Chemical Co., Ltd

Tetrahydro-4-pyranol Spectrum

Tetrahydro-4-pyranol(2081-44-9)MSTetrahydro-4-pyranol(2081-44-9)1HNMRTetrahydro-4-pyranol(2081-44-9)13CNMRTetrahydro-4-pyranol(2081-44-9)IR1Tetrahydro-4-pyranol(2081-44-9)IR2Tetrahydro-4-pyranol(2081-44-9)Raman

2081-44-9(Tetrahydro-4-pyranol)Related Search:

Tetrahydro-4H-pyran-4-one Tetrahydro-2H-pyran-4-carboxylic acid 4-Aminotetrahydropyran Centchroman Tetrahydropyran
TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE [(Tetrahydro-2H-pyran-4-yl)methyl]hydrazine dihydrochloride Tetrahydrofuran Pyrrolidine
2H-PYRAN-2-CARBONITRILE, TETRAHYDRO- Oxan-4-yl 4-methylbenzenesulfonate Tetrahydro-2H-pyran-4-carbonyl chloride Hexahydro-3H-pyrrolo[1,2-c]imidazole-1,3-dione TETRAHYDROTHIOPYRAN-4-OL 97
TETRAHYDRO-2H-PYRAN-3-CARBOXYLIC ACID 1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid Tetrahydropyranyl-4-acetic acid

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2H-PYRAN-4-OL, TETRAHYDRO TETRAHYDRO-4-PYRANOL 4-Hydroxytetrahydro-2H-pyran Tetrahydro-2H-pyran-4-ol, 97+% Tetrahydro-4-pyranol,4-Hydroxytetrahydropyran 4-Hydroxytetrahydro-2H-pyran 97% 3,4,5,6-Tetrahydro-2H-pyran-4-ol Tetrahydro-2H-pyran-4-ol, 4-Hydroxyoxane 4-tetrahydropyranol Tetrahydro-4-pranol Tetrahydro-4-pyranol 98% Tetrahydro-4-pyranol ISO 9001：2015 REACH TIANFU CHEM-Tetrahydro-4-pyranol Tetrahydro-4-pyranol,98% Oxan-4-ol 2H-Pyran-4-ol 4-HYDROXYTETRAHYDROPYRAN 4-HYDROXYTETRAHYDROPYAN POH TETRAHYDRO-4H-PYRAN-4-OL Tetrahydropyranol TETRAHYDRO-2H-PYRAN-4-OL Tetrahydropyran-4-ol 2081-44-9 2081-44-5 ALCOHOL Pyrans Heterocyclic Building Blocks Building Blocks Pyrans, Piperidines & Piperazines Pyrans, Piperidines &Piperazines Building Blocks Chemical Synthesis Heterocyclic Building Blocks Pyrans Alcohols and Derivatives Heterocycles