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Tetrahydro-4-pyranol

Tetrahydro-4-pyranol Structure
Tetrahydro-4-pyranol structure
CAS No.
2081-44-9
Chemical Name:
Tetrahydro-4-pyranol
Synonyms
TETRAHYDRO-2H-PYRAN-4-OL;Tetrahydropyran-4-ol;Oxan-4-ol;TETRAHYDRO-4H-PYRAN-4-OL;POH;Tetrahydropyranol;4-HYDROXYTETRAHYDROPYRAN;2H-Pyran-4-ol;4-HYDROXYTETRAHYDROPYAN;Tetrahydro-4-pranol
CBNumber:
CB0747105
Molecular Formula:
C5H10O2
Molecular Weight:
102.13
MDL Number:
MFCD00006633
MOL File:
2081-44-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:54:05
Request For Quotation

Tetrahydro-4-pyranol Properties

Boiling point 87 °C/15 mmHg (lit.)
Density 1.071 g/mL at 25 °C (lit.)
refractive index n20/D 1.462(lit.)
Flash point 190 °F
storage temp. Sealed in dry,Room Temperature
solubility Chloroform, Methanol
form Oil
pka 14.61±0.20(Predicted)
color Clear Colourless
BRN 102736
InChI InChI=1S/C5H10O2/c6-5-1-3-7-4-2-5/h5-6H,1-4H2
InChIKey LMYJGUNNJIDROI-UHFFFAOYSA-N
SMILES C1OCCC(O)C1
LogP -0.440 (est)
CAS DataBase Reference 2081-44-9(CAS DataBase Reference)
FDA UNII ZZ9W8N9YQV
NIST Chemistry Reference Tetrahydro-4H-pyran-4-ol(2081-44-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,Xn
Risk Statements  41-36/37/38-20/22
Safety Statements  26-39-36/37/39-23
RIDADR  1993
WGK Germany  3
HazardClass  IRRITANT
HS Code  29329990
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Dam. 1
REACH Registrations Active
NFPA 704
1
2 0

Tetrahydro-4-pyranol price More Price(95)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 198234 Tetrahydro-4-pyranol 98% 2081-44-9 5g $155 2026-04-30 Buy
Sigma-Aldrich 198234 Tetrahydro-4-pyranol 98% 2081-44-9 1g $44.4 2023-06-20 Buy
TCI Chemical T2825 Tetrahydro-4-pyranol >97.0%(GC) 2081-44-9 1g $18 2026-04-30 Buy
TCI Chemical T2825 Tetrahydro-4-pyranol >97.0%(GC) 2081-44-9 5g $25 2026-04-30 Buy
Usbiological 279769 4-Hydroxytetrahydropyan Asreported 2081-44-9 5g $442 2026-06-03 Buy
Product number Packaging Price Buy
198234 5g $155 Buy
198234 1g $44.4 Buy
T2825 1g $18 Buy
T2825 5g $25 Buy
279769 5g $442 Buy

Tetrahydro-4-pyranol Chemical Properties, Uses, Production

Chemical Properties

Colorless transparent liquid

Uses

Tetrahydro-4-pyranol (4-Hydroxytetrahydropyran) was used in the quantitative analysis of 3-hydroxytetrahydropyran (3-HTHP).

Uses

Tetrahydro-4-pyranol is a building block of various organic compounds and pharmaceuticals.

Synthesis

Tetrahydro-4H-pyran-4-one

29943-42-8

Tetrahydro-4-pyranol

2081-44-9

General procedure for the synthesis of tetrahydropyran-4-ol from tetrahydropyranone: To a tetrahydrofuran (THF, 25 mL) solution of tetrahydropyranone (5.0 g, 50 mmol), which was cooled to 0 °C, a THF (50 mL) suspension of lithium aluminum hydride (LiAlH4, 3.8 g, 0.1 mol) was slowly added. The reaction mixture was stirred at 0 °C for 30 min, followed by sequential addition of water (3.8 mL), 15% aqueous sodium hydroxide (NaOH) solution (3.8 mL) and water (11.4 mL) to quench the reaction. The mixture was filtered and the solid was washed with ethyl acetate (70 mL x 2). The filtrates were combined and evaporated to give tetrahydropyran-4-ol (5.09 g, 99% yield).

References

[1] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 39
[2] Patent: US9301951, 2016, B2. Location in patent: Page/Page column 125
[3] Chemistry - A European Journal, 2018, vol. 24, # 62, p. 16526 - 16531
[4] Patent: US2010/76029, 2010, A1. Location in patent: Page/Page column 35
[5] Patent: US2011/71196, 2011, A1. Location in patent: Page/Page column 18-19

Tetrahydro-4-pyranol synthesis

29943-42-8
2081-44-9
Synthesis of Tetrahydro-4-pyranol from Tetrahydro-4H-pyran-4-one

Tetrahydro-4-pyranol Preparation Products And Raw materials

Raw materials

Ethylene Phosphoric acid Sodium phosphate monobasic Aluminum chloride Tetrahydrofuran
Diethyl ether Lithium Aluminum Hydride Hydrochloric acid Dichloromethane Sodium hydroxide
3-Chloropropionyl chloride Magnesium sulfate

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Preparation Products

4-Bromo-tetrahydropyran 1-(Tetrahydro-2H-pyran-4-yl)hydrazine Tetrahydropyran-4-carbaldehyde 2-(tetrahydro-2H-pyran-4-yloxy)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 4-Iodotetrahydro-2H-pyran
Tetrahydropyranyl-4-acetic acid 3-Pyridinol, 5-chloro-6-[(tetrahydro-2H-pyran-4-yl)oxy]-

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Tetrahydro-4-pyranol Suppliers

Global Suppliers ( 330)
Supplier Tel Email Country ProdList Advantage
ITIC MEDCHEM(SUZHOU) CO.,LTD. 0512-68323967 18015559028 sales@iticmedchem.com China 528 61
BTC Pharmaceutical CO. Ltd +86-15716293042 15716293042 info@btcpharm.com China 822 55
Suzhou ChonTech Biopharma Co.,Ltd 0512-63101022 13912623614 sales@chontech.com Austria 220 58
Shanghai yongzeng technology co., LTD 021-021-021-65281118 15921781258 sales@yongzchem.com China 70 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Supplier Advantage
ITIC MEDCHEM(SUZHOU) CO.,LTD. 61
BTC Pharmaceutical CO. Ltd 55
Suzhou ChonTech Biopharma Co.,Ltd 58
Shanghai yongzeng technology co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56

View Latest Price from Tetrahydro-4-pyranol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tetrahydro-4-pyranol pictures 2026-09-16 Tetrahydro-4-pyranol
2081-44-9
 1KG ≥98% 100mt/year Jinan Finer Chemical Co., Ltd
Tetrahydro-4-pyranol pictures 2026-09-16 Tetrahydro-4-pyranol
2081-44-9
 1KG 99%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
Tetrahydro-4-pyranol pictures 2026-09-02 Tetrahydro-4-pyranol
2081-44-9
 $1.50-31.00 1kg 99% Henan Fengda Chemical Co., Ltd

Tetrahydro-4-pyranol Spectrum

Tetrahydro-4-pyranol(2081-44-9)MSTetrahydro-4-pyranol(2081-44-9)1HNMRTetrahydro-4-pyranol(2081-44-9)13CNMRTetrahydro-4-pyranol(2081-44-9)IR1Tetrahydro-4-pyranol(2081-44-9)IR2Tetrahydro-4-pyranol(2081-44-9)Raman

2081-44-9 (Tetrahydro-4-pyranol) Related Search:

Tetrahydro-4H-pyran-4-one Tetrahydro-2H-pyran-4-carboxylic acid 4-Aminotetrahydropyran Centchroman Tetrahydropyran
[(Tetrahydro-2H-pyran-4-yl)methyl]hydrazine dihydrochloride Tetrahydrofuran Pyrrolidine 2H-Pyran-2-carbonitrile, tetrahydro- Tetrahydro-2H-pyran-4-carboxamide
Tetrahydro-2H-pyran-4-ylacetyl chloride Oxan-4-yl 4-methylbenzenesulfonate Tetrahydro-2H-pyran-4-carbonyl chloride Hexahydro-3H-pyrrolo[1,2-c]imidazole-1,3-dione 1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid
Tetrahydrothiopyran-4-ol 97 Tetrahydro-2H-pyran-3-carboxylic acid Tetrahydropyranyl-4-acetic acid

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2H-PYRAN-4-OL, TETRAHYDRO TETRAHYDRO-4-PYRANOL 4-Hydroxytetrahydro-2H-pyran Tetrahydro-2H-pyran-4-ol, 97+% Tetrahydro-4-pyranol,4-Hydroxytetrahydropyran 4-Hydroxytetrahydro-2H-pyran 97% 3,4,5,6-Tetrahydro-2H-pyran-4-ol Tetrahydro-2H-pyran-4-ol, 4-Hydroxyoxane 4-tetrahydropyranol Tetrahydro-4-pranol Tetrahydro-4-pyranol 98% Tetrahydro-4-pyranol ISO 9001：2015 REACH TIANFU CHEM-Tetrahydro-4-pyranol Tetrahydro-4-pyranol,98% Oxan-4-ol 2H-Pyran-4-ol 4-HYDROXYTETRAHYDROPYRAN 4-HYDROXYTETRAHYDROPYAN POH TETRAHYDRO-4H-PYRAN-4-OL Tetrahydropyranol TETRAHYDRO-2H-PYRAN-4-OL Tetrahydropyran-4-ol Tetrahydro-4-pyrano 2081-44-9 2081-44-5 ALCOHOL Pyrans Heterocyclic Building Blocks Building Blocks Pyrans, Piperidines & Piperazines Pyrans, Piperidines &Piperazines Building Blocks Chemical Synthesis Heterocyclic Building Blocks Pyrans Alcohols and Derivatives Heterocycles