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CGP 20712 A

CGP 20712 A structure

CAS No.: 105737-62-0

Chemical Name:: CGP 20712 A

Synonyms: CGP207122HCl;CGP 20712 mesylate;CGP 20712 DIHYDROCHLORIDE;CGP-20712A methanesulfonate salt;CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE;CGP-20712A methanesulfonate salt solid, >=98% (HPLC);1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd;1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate;1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE;(+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate

CBNumber:: CB4380786

Molecular Formula:: C24H29F3N4O8S

Molecular Weight:: 590.57

MDL Number:: MFCD06798358

MOL File:: 105737-62-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:14

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CGP 20712 A Properties

storage temp.	2-8°C
solubility	H₂O: 10 mg/mL
form	solid
color	white
Water Solubility	H2O: >10mg/mL DMSO: 100mg/mL
InChIKey	VFPOVCXWKBYDNF-UHFFFAOYSA-N
SMILES	CS(O)(=O)=O.Cn1cc(nc1-c2ccc(OCC(O)CNCCOc3ccc(O)c(c3)C(N)=O)cc2)C(F)(F)F
FDA UNII	CNU8DA2K9J
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
Storage Class	11 - Combustible Solids

CGP 20712 A price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C231	CGP-20712A methanesulfonate salt solid, ≥98% (HPLC)	105737-62-0	10mg	$359	2026-04-30	Buy
Sigma-Aldrich	C231	CGP-20712A methanesulfonate salt solid, ≥98% (HPLC)	105737-62-0	50mg	$1270	2023-01-07	Buy
Cayman Chemical	40765	CGP 20712A ≥95%	105737-62-0	1mg	$39	2026-04-30	Buy
Cayman Chemical	40765	CGP 20712A ≥95%	105737-62-0	5mg	$164	2026-04-30	Buy
Cayman Chemical	40765	CGP 20712A ≥95%	105737-62-0	10mg	$251	2026-04-30	Buy

Product number	Packaging	Price	Buy
C231	10mg	$359	Buy
C231	50mg	$1270	Buy
40765	1mg	$39	Buy
40765	5mg	$164	Buy
40765	10mg	$251	Buy

CGP 20712 A Chemical Properties,Uses,Production

Uses

CGP-20712A methanesulfonate salt has been used as a β1-adrenergic receptor antagonist in adult rat ventricular myocytes (ARVM) and rat cardiac fibroblasts. It may also be used as an antagonist for the β1-adrenergic receptor in rat bladder smooth muscles.

Biological Activity

Highly selective and potent β 1 -adrenoceptor antagonist (IC 50 = 0.7 nM). Displays 10,000-fold selectivity over β 2 -adrenoceptors. Also available as part of the β -Adrenoceptor Antagonist Tocriset™ .

Biochem/physiol Actions

CGP-20712A methanesulfonate salt is a selective β1-adrenoceptor antagonist.

in vitro

In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.

in vivo

Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.

IC 50

β adrenergic receptor

CGP 20712 A Preparation Products And Raw materials

Raw materials

Preparation Products

CGP 20712 A Suppliers

Global( 32)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
HBCChem, Inc.	+1-510-219-6317	sales@hbcchem.com	United States	10628	60
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Nanjing Shizhou Biotechnology Co., Ltd	025-0258556344 17301488900	rose.shi@synzest.com	China	271	58
Energy Chemical	400-0056266	marketing1@energy-chemical.com	China	44927	58
cjbscvictory	13348960310 13348960310	3003867561@qq.com	China	10233	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	27626	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58
Wuhan Jingkangen Biomedical Technology Co., Ltd	13720134139 086-15871494362 13720134139	orders@jknbiochem.com	China	7283	58

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
HBCChem, Inc.	60
Sigma-Aldrich	80
TargetMol Chemicals Inc.	58
Nanjing Shizhou Biotechnology Co., Ltd	58
Energy Chemical	58
cjbscvictory	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Jingkangen Biomedical Technology Co., Ltd	58

105737-62-0(CGP 20712 A )Related Search:

1-(2-Hydroxy-ethylamino)-3-phenoxy-propan-2-ol 2-(4-Ethoxy-phenyl)-1H-imidazole 2-Methyl-4-trifluoromethylimidazole CGP 20712 A 4-(Trifluoromethyl)-1H-imidazole

2-Phenyl-4-(trifluoromethyl)-1H-imidazole

1of2

CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE 1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd CGP207122HCl CGP-20712A methanesulfonate salt (±)-2-Hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy]propyl] amino]ethoxy]-benzamide methanesulfonate salt 1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE CGP 20712 DIHYDROCHLORIDE (+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate CGP 20712 mesylate 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate CGP-20712A methanesulfonate salt solid, >=98% (HPLC) 105737-62-0 C23H25F3N4O5CH4O3S C24H27F3N4O7S C23H25F3N4O52HCl Adrenoceptor