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ETHYL 3,3,3-TRIFLUOROPROPIONATE

ETHYL 3,3,3-TRIFLUOROPROPIONATE structure

CAS No.: 352-23-8

Chemical Name:: ETHYL 3,3,3-TRIFLUOROPROPIONATE

Synonyms: Ethyl 3,3,3-trifluoropropanoate;uoropropionate;RARECHEM AL BI 1046;Ethyl trifluoropropionate;ETHYL 3,3,3-TRIFLUOROPROPIOTE;ETHYL 3,3,3-TRIFLUOROPROPIONATE;Ethyl3,3,3-trifluoropropionate97%;Ethyl 3,3,3-trifluoropropionate 97%;Ethyl 3,3,3-trifluoropropanoate 97%;Propanoic acid, 3,3,3-trifluoro-, ethyl ester

CBNumber:: CB4397142

Molecular Formula:: C5H7F3O2

Molecular Weight:: 156.1

MDL Number:: MFCD01348113

MOL File:: 352-23-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:21:28

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ETHYL 3,3,3-TRIFLUOROPROPIONATE Properties

Melting point	109 °C
Boiling point	50°C 12mm
Density	1.192
refractive index	1.3912
Flash point	8℃
storage temp.	2-8°C
solubility	Chloroform (Sparingly), Ethyl Acetate (Soluble)
form	Oil
color	Colourless
InChI	InChI=1S/C5H7F3O2/c1-2-10-4(9)3-5(6,7)8/h2-3H2,1H3
InChIKey	FMDMKDPUFQNVSH-UHFFFAOYSA-N
SMILES	C(OCC)(=O)CC(F)(F)F

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes	F,Xi
Risk Statements	10
Safety Statements	16-24/25
RIDADR	3272
Hazard Note	Flammable
HazardClass	IRRITANT, FLAMMABLE
HS Code	29159000
Limited Quantities	1.0 L (0.3 gallon) (liquid)
Excepted Quantities	Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

ETHYL 3,3,3-TRIFLUOROPROPIONATE price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-B440230-500MG	Ethyl 3,3,3-Trifluoropropanoate	352-23-8	500mg	$84	2026-06-03	Buy
TRC	TRC-B440230-250MG	Ethyl 3,3,3-Trifluoropropanoate	352-23-8	250mg	$65	2026-06-03	Buy
TRC	TRC-B440230-1G	Ethyl 3,3,3-Trifluoropropanoate	352-23-8	1g	$152	2026-06-03	Buy
Apolloscientific	PC5769	Ethyl 3,3,3-trifluoropropanoate 99%	352-23-8	1g	$21	2026-06-04	Buy
Apolloscientific	PC5769	Ethyl 3,3,3-trifluoropropanoate 99%	352-23-8	5g	$22	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-B440230-500MG	500mg	$84	Buy
TRC-B440230-250MG	250mg	$65	Buy
TRC-B440230-1G	1g	$152	Buy
PC5769	1g	$21	Buy
PC5769	5g	$22	Buy

ETHYL 3,3,3-TRIFLUOROPROPIONATE Chemical Properties,Uses,Production

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 7689, 1991 DOI: 10.1016/0040-4039(91)80566-O

Synthesis

421-90-9

917-58-8

352-23-8

4.4 General procedure for the preparation of ethyl 3,3,3-trifluoropropionate: (1) To a stirred suspension of potassium ethoxide (KOEt, 5.0 g, 59.4 mmol) in ether (Et2O, 200 mL), a solution of 2,2,3-tribromo-1,1,1-trifluoropropane (7, 6.0 g, 17.9 mmol) in ether (Et2O, 50 mL) was slowly added dropwise. The reaction mixture was stirred at room temperature for 15 min. Subsequently, the reaction was quenched with 1 M aqueous hydrochloric acid (50 mL) and stirring was continued for 30 min. The aqueous layer was separated and extracted with ether (50 mL × 3) and the combined organic phases were washed with brine (40 mL) and dried with anhydrous magnesium sulfate (MgSO4). The solvent was removed by concentration under reduced pressure to give the crude product. Purification of the crude product by distillation afforded ethyl 3,3,3-trifluoropropionate (1, 2.0 g, 72%) as a colorless oil with a boiling point of 106°C (760 mmHg). Product characterization data: IR (pure): 2989, 1747, 1384, 1360, 1267, 1216, 1110, 1026, 929, 836, 755, 653 cm-1. 1H NMR (400 MHz, CDCl3): δ 4.24 (q, J = 7.2 Hz, 2H), 3.17 (q, J = 10.1 Hz, 2H), 1.30 (t, J = 7.2 Hz, 3H). 13C NMR (100 MHz, CDCl3): δ 164.1 (q, JCF = 4.1 Hz, 1C), 123.4 (q, JCF = 274.5 Hz, 1C), 61.7 (1C), 39.5 (q, JCF = 30.8 Hz, 1C), 13.8 (1C). 19F NMR (376 MHz, CDCl3): δ -64.8 (t, JHF = 10.1 Hz, 3F). EI-MS m/z (relative abundance): 156 [M]+ (2.4), 141 [M-Me]+ (1.4), 129 [M+2H-Et]+ (8.2), 111 [M-OEt]+ (100), 91 [CF2CHCO]+ (12.9), 83 [CF3CH2]+ (15.7), 69 [CF3]+ (7.5) , 45 [EtO]+ (41.4).

References

[1] Journal of Fluorine Chemistry, 2014, vol. 167, p. 135 - 138

ETHYL 3,3,3-TRIFLUOROPROPIONATE Preparation Products And Raw materials

Raw materials

ethyl 3,3,3-trifluoro-2-(trifluoromethyl)propanoate 1,2,2-TRIBROMO-3,3,3-TRIFLUOROPROPANE Ethanol Potassium ethylate 3,3,3-Trifluoropropionic acid

Preparation Products

3',5'-Dichloro-2,2,2-trifluoroacetophenone ETHYL 2-(5-CHLOROBENZO[D]OXAZOL-2-YL)ACETATE (5-Methyl-[1,3,4]oxadiazol-2-yl)-acetic acid ethyl ester

ETHYL 3,3,3-TRIFLUOROPROPIONATE Suppliers

Global( 123)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Liteng Biotechnology Co., Ltd	15020019777 18663721413	rosy@litengpharm.com	China	1615	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Changzhou Huanling Chemical Co., Ltd.	89803005 18206112582	info@huanlingchem.com	China	983	68
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64

Supplier	Advantage
Shandong Liteng Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
future industrial shanghai co., ltd	65
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Changzhou Huanling Chemical Co., Ltd.	68
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62
Accela ChemBio Co.,Ltd.	64

View Lastest Price from ETHYL 3,3,3-TRIFLUOROPROPIONATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	Ethyl 3,3,3-trifluoropropanoate 352-23-8	$1.10-9.90	1KG	99%min	100KG	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2025-04-04	ETHYL 3,3,3-TRIFLUOROPROPIONATE 352-23-8		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2020-01-09	ETHYL 3,3,3-TRIFLUOROPROPIONATE 352-23-8	$3.00	1KG	98%	200KG	Career Henan Chemical Co

Ethyl 3,3,3-trifluoropropanoate
352-23-8
$1.10-9.90
99%min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

ETHYL 3,3,3-TRIFLUOROPROPIONATE
352-23-8
98%
Henan Aochuang Chemical Co.,Ltd.

ETHYL 3,3,3-TRIFLUOROPROPIONATE
352-23-8
$3.00
98%
Career Henan Chemical Co

ETHYL 3,3,3-TRIFLUOROPROPIONATE Spectrum

ETHYL 3,3,3-TRIFLUOROPROPIONATE(352-23-8)¹HNMR

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RARECHEM AL BI 1046 ETHYL 3,3,3-TRIFLUOROPROPIONATE Ethyl 3,3,3-trifluoropropionate 97% Ethyl3,3,3-trifluoropropionate97% Propanoic acid, 3,3,3-trifluoro-, ethyl ester Ethyl 3,3,3-trifluoropropanoate 97% ETHYL 3,3,3-TRIFLUOROPROPIOTE uoropropionate Ethyl 3,3,3-trifluoropropanoate Ethyl trifluoropropionate 352-23-8