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DIHYDROFOLIC ACID

DIHYDROFOLIC ACID structure

CAS No.: 4033-27-6

Chemical Name:: DIHYDROFOLIC ACID

Synonyms: dihydrofolate;FAH2;DIHYDROFOLIC ACID;FolinicAcidEPImpurityGHCl;Folinic Acid EP Impurity G;Levofolinate EP Impurity G;Impurity G (hydrochloride);7,8-Dihydrofolic acid (DHF);DIHYDROPTEROYL-L-GLUTAMIC ACID;Folic Acid 7,8-Dihydro Impurity

CBNumber:: CB4432012

Molecular Formula:: C19H21N7O6

Molecular Weight:: 443.41

MDL Number:: MFCD00083619

MOL File:: 4033-27-6.mol

MSDS File:: SDS

Last updated:2026-01-13 11:21:15

Product description	Number	Pack Size	Price
Dihydrofolic acid ≥90%	D7006	10mg	$131
Dihydrofolic acid ≥90%	D7006	25mg	$295
Dihydrofolic acid ≥90%	D7006	100mg	$980
Dihydrofolic acid	D449700	25mg	$200
Dihydro Folic Acid	FD170209	10mg	$200
More product size

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DIHYDROFOLIC ACID Properties

Melting point	>160°C (dec.)
Density	1.69±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	0.1 M NaOH: 10 mg/mL, slightly hazy, orange
pka	pKa 1.38(H2O t=25 I=0.10) (Occasionally);3.84(H2O t=25 I=0.10) (Occasionally)
form	Solid
color	Light Beige to Beige
biological source	synthetic (organic)
BRN	69017
Stability	Air Sensitive, Hygroscopic, Temperature Sensitive
InChIKey	OZRNSSUDZOLUSN-LBPRGKRZSA-N
SMILES	NC1=NC(=O)C2=C(NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1
FDA UNII	KXP0KNM559
UNSPSC Code	12352106
NACRES	NA.79

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

DIHYDROFOLIC ACID price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D7006	Dihydrofolic acid ≥90%	4033-27-6	10mg	$131	2025-07-31	Buy
Sigma-Aldrich	D7006	Dihydrofolic acid ≥90%	4033-27-6	25mg	$295	2025-07-31	Buy
Sigma-Aldrich	D7006	Dihydrofolic acid ≥90%	4033-27-6	100mg	$980	2025-07-31	Buy
TRC	D449700	Dihydrofolic acid	4033-27-6	25mg	$200	2021-12-16	Buy
Biosynth Carbosynth	FD170209	Dihydro Folic Acid	4033-27-6	10mg	$200	2021-12-16	Buy

Product number	Packaging	Price	Buy
D7006	10mg	$131	Buy
D7006	25mg	$295	Buy
D7006	100mg	$980	Buy
D449700	25mg	$200	Buy
FD170209	10mg	$200	Buy

DIHYDROFOLIC ACID Chemical Properties,Uses,Production

Uses

antidote to methotrexate toxicity

Uses

Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).

Definition

ChEBI: Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a dihydrofolate(2-).

General Description

Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase.

Biochem/physiol Actions

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Purification Methods

DHFA is best purified by suspending (1g mostly dissolved)) in ice-cold sodium ascorbate (300mL of 10% at pH 6.0, prepared by adjusting the pH of 30g of sodium ascorbate in 150mL of H2O by adding 1N NaOH dropwise using a gla

DIHYDROFOLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid L-Tetrahydrofolic Acid

DIHYDROFOLIC ACID Suppliers

Global( 118)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3589	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32470	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15080	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39042	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49964	58
R&D Scientific Inc.	+1-2266000236	sales@rdscientific.com	Canada	1929	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
AFINE CHEMICALS LIMITED	58
Hefei Hirisun Pharmatech Co., Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Nextpeptide Inc	58
TargetMol Chemicals Inc.	58
GIHI CHEMICALS CO.,LIMITED	58
R&D Scientific Inc.	58

View Lastest Price from DIHYDROFOLIC ACID manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-13	Dihydrofolic acid 4033-27-6	US $1980.00-1520.00 / mg			10g	TargetMol Chemicals Inc.
2025-12-12	DIHYDROFOLIC ACID 4033-27-6	US $1.00-2.00 / KG	1KG	99%	10000KG	Shaanxi Dideu Medichem Co. Ltd
2025-12-12	DIHYDROFOLIC ACID 4033-27-6	US $0.10-0.10 / KG	10KG	99%+	10000KG	Shaanxi Dideu Medichem Co. Ltd

Dihydrofolic acid
4033-27-6
US $1980.00-1520.00 / mg
TargetMol Chemicals Inc.

DIHYDROFOLIC ACID
4033-27-6
US $1.00-2.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

DIHYDROFOLIC ACID
4033-27-6
US $0.10-0.10 / KG
99%+
Shaanxi Dideu Medichem Co. Ltd

4033-27-6(DIHYDROFOLIC ACID)Related Search:

Vitamin B12 Glycine Calcium N5-methyltetrahydrofolate Folic acid 2-[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]aminopentanedioic acid

Calcium levofolinate 5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid 10-Formylfolic Acid Folinic Acid IMpurity E 2-Amino-7-(chloromethyl)pteridin-4(1H)-one

2,4,5-Triamino-6-hydroxypyrimidine sulfate (S)-N-[4-[[(2-AMino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-glutaMic Acid 6-hydroxymethylpterin Folic Acid Impurity C 5-Methyl Tetrahedropteroic Acid (Mixture of DiastereoMers)

folcysteine (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6- yl]methylamino]benzoyl]amino]pentanedioic acid 6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE

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Folinic Acid EP Impurity G Folinic Acid EP Impurity G (7,8-Dihydrofolic Acid) (S)-2-(4-(((2-aMino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid 7,8-Dihydrofolic acid (DHF) Dihydrofolic acid 7,8-Dihydropteroyl-L-glutaMic acid N-[4-[[(2-aMino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-GlutaMic acid Folinic Acid Impurity G (7,8-Dihydrofolic Acid) 7,8-DIHYDROPTEROYL-L-GLUTAMIC ACID FAH2 DIHYDROPTEROYL-L-GLUTAMIC ACID DIHYDROFOLIC ACID dihydrofolate 2-[4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid 7,8-Dihydropteroyl-L-glutamic acid, Dihydropteroyl-L-glutamic acid, FAH2 N-[4-[[[(2-Amino-1,4,5,6-tetrahydro-4-oxopteridin)-6-yl]methyl]amino]benzoyl]-L-glutamic acid Folic acid impurity 2/Folinic Acid EP Impurity G/Dihydrofolic acid/7,8-Dihydrofolic Acid Impurity G of Calcium Levofolinate Folic Acid 7,8-Dihydro Impurity Levofolinate EP Impurity G L-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- 2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid Calcium levoflonate EP impurity G (4-(((2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid FolinicAcidEPImpurityGHCl (S)-2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid (4-(((2-Imino-4-Oxo-1,2,3,4,7,8-Hexahydropteridin-6-Yl)Methyl)Amino)Benzoyl)-L-Glutamicacid Impurity G (hydrochloride) Folinic Acid EP Impurity G Sulfate 4033-27-6 40033-27-6 C19H21N7O6 Cell Signaling Enzymes Application Index Biochemicals and Reagents BioChemical Cofactors Dihydrofolate reductase Enzymes, Inhibitors, and Substrates Oxidation-Reduction Substrate/Cofactor