2,4,5-Triamino-6-hydroxypyrimidine sulfate
- CAS No.
- 35011-47-3
- Chemical Name:
- 2,4,5-Triamino-6-hydroxypyrimidine sulfate
- Synonyms
- 2,5,6-Triamino-4(1H)-pyrimidinone sulfate;2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE HYDRATE;TAPOS;4-Hydr;NSC 167378;Triammoniacompound;Folic acid Impurity 69;Folic Acid Impurity 26;Folic Acid Impurity B Sulfate;Folic Acid EP Impurity B Sulfate
- CBNumber:
- CB0447678
- Molecular Formula:
- C4H9N5O5S
- Molecular Weight:
- 239.21
- MDL Number:
- MFCD00150093
- MOL File:
- 35011-47-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Folic Acid Impurity B Pharmaceutical Secondary Standard; Certified Reference Material | PHR2001 | 20MG | $647 |
| 2,4,5-Triamino-6-hydroxypyrimidine Sulfate Hydrate >90.0%(T) | T0335 | 25g | $34 |
| 6-Hydroxy-2,4,5-triaminopyrimidine,Sulfate | H971250 | 1g | $100 |
| 2,5,6-Triamino-4(3H)-pyrimidinoneSulfate | T767240 | 10g | $110 |
| 6-Hydroxy-2,4,5-triaminopyrimidine,Sulfate | H971250 | 2.5g | $125 |
| More product size | |||
| Melting point | ≥300 °C(lit.) |
|---|---|
| RTECS | UW7175000 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in DMSO. |
| form | Solid |
| color | Pale Yellow |
| InChI | InChI=1S/C4H7N5O.H2O4S/c5-1-2(6)8-4(7)9-3(1)10;1-5(2,3)4/h5H2,(H5,6,7,8,9,10);(H2,1,2,3,4) |
| InChIKey | RSKNEEODWFLVFF-UHFFFAOYSA-N |
| SMILES | NC1C(N=C(N)NC=1N)=O.S(O)(O)(=O)=O |
| CAS DataBase Reference | 35011-47-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
2,4,5-Triamino-6-hydroxypyrimidine sulfate price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2001 | Folic Acid Impurity B Pharmaceutical Secondary Standard; Certified Reference Material | 35011-47-3 | 20MG | $647 | 2024-03-01 | Buy |
| TCI Chemical | T0335 | 2,4,5-Triamino-6-hydroxypyrimidine Sulfate Hydrate >90.0%(T) | 35011-47-3 | 25g | $34 | 2025-07-31 | Buy |
| TRC | H971250 | 6-Hydroxy-2,4,5-triaminopyrimidine,Sulfate | 35011-47-3 | 1g | $100 | 2021-12-16 | Buy |
| TRC | T767240 | 2,5,6-Triamino-4(3H)-pyrimidinoneSulfate | 35011-47-3 | 10g | $110 | 2021-12-16 | Buy |
| TRC | H971250 | 6-Hydroxy-2,4,5-triaminopyrimidine,Sulfate | 35011-47-3 | 2.5g | $125 | 2021-12-16 | Buy |
2,4,5-Triamino-6-hydroxypyrimidine sulfate Chemical Properties,Uses,Production
application
6-Hydroxy-2,4,5-triaminopyrimidine, Sulfate (cas# 35011-47-3) is a compound useful in organic synthesis.
Chemical Properties
yellow-beige crystalline powder
Uses
2,4,5-Triamino-6-hydroxypyrimidine sulfate is used in the preparation of guanines and other purine derivatives with antiviral activities.
Uses
2,4,5-Triamino-6-hydroxypyrimidine Sulfate Salt is an intermediate used in the preparation of labelled 2-Amino-6,8-dihydroxypurine Hydrochloride (A604920). A labelled substituted 5-aminopyrimidines with antioxidative activity.
Synthesis
3.875g (0.016mol) of 2,4-diamino-5-nitroso-6-hydroxypyrimidine with 36% water content was put into a 200ml high-pressure reactor with stirring, and 0.02g of sodium dodecylbenzene sulfonate was measured and added into 80ml of deionized water to form a suspension, and then palladium and carbon (in which palladium and carbon were added by mass) were added. 0.02g of sodium dodecylbenzenesulfonate, measured to add 80ml of deionized water, stirring and dispersion to form a suspension, and then add the solid content of 34.29% of palladium-carbon (in which the mass ratio of palladium, carbon is 5:95) 0.3164g, N2 protection under the heating to 40 C, through the H2, control of the H2 pressure of 2MPa, the reaction is over after 5h. Add 2 mol·l-1 hydrochloric acid solution dropwise in the reaction solution to adjust the pH value to between 3-4, stirred thoroughly, filtered and separated. The filtrate was adjusted to pH 1-2 with 2 mol·l-1 sulfuric acid solution, left to stand for 30 min, cooled and crystallized, and the product 2,4,5-triamino-6-hydroxypyrimidine sulfate was filtered after complete precipitation. Completely precipitated after filtration, the filter cake is white crystals, after drying to get the finished product 2,4,5-triamino-6-hydroxypyrimidine sulfate 3.76g, purity is 98.3%.
Purification Methods
This salt has very low solubility in H2O. It is best purified by conversion into the dihydrochloride salt, which is then re-converted to the insoluble sulfate salt. The sulfate salt (2.57g, 10mmoles) is suspended in H2O (20mL) containing BaCl2 (10mmoles) and stirred in a boiling water bath for 15minutes. After cooling, the insoluble BaSO4 is filtered off and washed with boiling H2O (10mL). The combined filtrate and washings are made acidic with HCl and evaporated to dryness. The residual hydrochloride salt is recrystallised from H2O by adding conc HCl whereby the dihydrochloride salt separates as clusters which darken at 260o and dec > 300o[darkening > 360o]. [Baugh & Shaw J Org Chem 29 3610 1964, King & Spengley J Chem Soc 2144 1952]. The hydrochloride is then dissolved in H2O, and while hot an equivalent of H2SO4 is added when the sulfate separates as a white microcrystalline solid which is filtered off washed liberally with H2O and dried in vacuum over P2O5. [Albert & Wood J Appl Chem London 3 521 1953, UV: Cavalieri et al. J Am Chem Soc 70 3875 1948; see also Pfleiderer Chem Ber 90 2272 1957, Traube Chem Ber 33 1371 1900.] The hydrochloride has m > 300o. [Beilstein 25 II 384, 25 III/IV 3648.]
2,4,5-Triamino-6-hydroxypyrimidine sulfate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28387 | 80 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-17392712697 | 1022@dideu.com | China | 3995 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21597 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2988 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
View Lastest Price from 2,4,5-Triamino-6-hydroxypyrimidine sulfate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-13 | 2,4,5-Triamino-6-hydroxypyrimidine sulfate
35011-47-3
|
US $0.00-0.00 / Kg/Drum | 1KG | 99%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-12-24 | 2,4,5-Triamino-6-hydroxypyrimidine sulfate
35011-47-3
|
US $0.10 / KG | 1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-12-01 | 2,4,5-Triamino-6-hydroxypyrimidine sulfate
35011-47-3
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2,4,5-Triamino-6-hydroxypyrimidine sulfate
35011-47-3
- US $0.00-0.00 / Kg/Drum
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2,4,5-Triamino-6-hydroxypyrimidine sulfate
35011-47-3
- US $0.10 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2,4,5-Triamino-6-hydroxypyrimidine sulfate
35011-47-3
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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