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5-Chloro-8-hydroxyquinoline

5-Chloro-8-hydroxyquinoline structure

CAS No.: 130-16-5

Chemical Name:: 5-Chloro-8-hydroxyquinoline

Synonyms: Cloxyquin;cloxiquine;Cloxiquin;5-CHLORO-8-QUINOLINOL;Cloxyqui;Chlorisept;Cloxyquine;Dermofungin;DERMOFONGIN;5-CHLOROOXINE

CBNumber:: CB4434834

Molecular Formula:: C9H6ClNO

Molecular Weight:: 179.6

MDL Number:: MFCD00006788

MOL File:: 130-16-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-08-29 11:56:07

Product description	Number	Pack Size	Price
5-Chloro-8-quinolinol 95%	C47000	100g	$75.3
5-Chloro-8-hydroxyquinoline >98.0%(GC)(T)	C0645	25g	$36
5-Chloro-8-hydroxyquinoline >98.0%(GC)(T)	C0645	250g	$158
Dermofungin >95%(HPLC)	TRC-D281930-50G	50g	$451
Dermofungin >95%(HPLC)	TRC-D281930-1G	1g	$192
More product size

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5-Chloro-8-hydroxyquinoline Properties

Melting point	122-124 °C(lit.)
Boiling point	348.7±22.0 °C(Predicted)
Density	1.2364 (rough estimate)
vapor pressure	0.003Pa at 25℃
refractive index	1.5330 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	0.019g/l (experimental)
form	Powder
pka	3.77±0.10(Predicted)
color	Light green to gray
Sensitive	Light Sensitive
Merck	14,2422
BRN	5289
InChI	1S/C9H6ClNO/c10-7-3-4-8(12)9-6(7)2-1-5-11-9/h1-5,12H
InChIKey	RWPWQYXFGFYJBA-UHFFFAOYSA-N
SMILES	Oc1ccc(Cl)c2cccnc12
CAS DataBase Reference	130-16-5(CAS DataBase Reference)
FDA 21 CFR	310.545
EWG's Food Scores	1
FDA UNII	BPF36H1G6S
NIST Chemistry Reference	8-Quinolinol, 5-chloro-(130-16-5)
EPA Substance Registry System	8-Quinolinol, 5-chloro- (130-16-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS09

Signal word

Warning

Hazard statements

H315-H319-H335-H410

Precautionary statements

P261-P264-P271-P273-P302+P352-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-24/25

WGK Germany

RTECS

VC4590000

TSCA

TSCA listed

HS Code

29334990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2
Skin Sens. 1

REACH Registrations

Active

NFPA 704

	0
2		0

5-Chloro-8-hydroxyquinoline price More Price(76)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C47000	5-Chloro-8-quinolinol 95%	130-16-5	100g	$75.3	2026-04-30	Buy
TCI Chemical	C0645	5-Chloro-8-hydroxyquinoline >98.0%(GC)(T)	130-16-5	25g	$36	2026-04-30	Buy
TCI Chemical	C0645	5-Chloro-8-hydroxyquinoline >98.0%(GC)(T)	130-16-5	250g	$158	2026-04-30	Buy
TRC	TRC-D281930-50G	Dermofungin >95%(HPLC)	130-16-5	50g	$451	2026-06-03	Buy
TRC	TRC-D281930-1G	Dermofungin >95%(HPLC)	130-16-5	1g	$192	2026-06-03	Buy

Product number	Packaging	Price	Buy
C47000	100g	$75.3	Buy
C0645	25g	$36	Buy
C0645	250g	$158	Buy
TRC-D281930-50G	50g	$451	Buy
TRC-D281930-1G	1g	$192	Buy

5-Chloro-8-hydroxyquinoline Chemical Properties,Uses,Production

Chemical Properties

light green to grey powder

Uses

antibacterial, antifungal

Uses

Dermofungin, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.

Definition

ChEBI: Cloxiquine is a member of quinolines and an organochlorine compound.

Synthesis Reference(s)

The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x

Synthesis

3054-95-3

95-85-2

130-16-5

GENERAL PROCEDURE: A 1N HCl solution (82.5 mL) was added to a round-bottomed flask containing 4-chloro-2-aminophenol (~1 mmol). Acrolein diethyl acetal (2.5 mmol) was added to the reaction mixture. The resulting solution was refluxed at 111°C for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and neutralized to pH 7-8 with solid Na2CO3. Subsequently, the product was extracted with dichloromethane (3 x 100 mL), the organic layers were combined and dried with anhydrous Na2SO4. After removal of solvent by evaporation under reduced pressure, the crude product was purified by column chromatography with the eluent being a mixture of 15% ethyl acetate/cyclohexane and methanol to afford the target compound 5-chloro-8-hydroxyquinoline.

in vitro

Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis .
Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.|
Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells.
Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells.

in vivo

Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model.
Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model.

References

[1] Tetrahedron Letters, 2015, vol. 56, # 46, p. 6436 - 6439

5-Chloro-8-hydroxyquinoline synthesis

Synthesis of 5-Chloro-8-hydroxyquinoline from Acrolein diethyl acetal and 2-Amino-4-chlorophenol

5-Chloro-8-hydroxyquinoline Preparation Products And Raw materials

Raw materials

8-Hydroxyquinoline Acrolein diethyl acetal 2-Amino-4-chlorophenol Water Hydrochloric acid

Preparation Products

1,2,3,4-Tetrahydro-8-hydroxyquinoline Quinoline, 5-chloro-8-phenoxy- 5-CHLORO-1,2,3,4-TETRAHYDRO-QUINOLIN-8-OL 8-Quinolinol, 5-chloro-7-(2-propen-1-yl)-

5-Chloro-8-hydroxyquinoline Suppliers

Global( 479)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hefei Lbao Physical & Chemical Science Co.,Ltd	+1-5184799099;	lbaochemicals@gmail.com	China	670	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21533	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Zhengzhou Alfa Chemical Co.,Ltd	+86-18530059196	sale04@alfachem.cn	China	9666	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34526	58
Dideu Industries Group Limited	+8617392712697	1022@dideu.com	China	29091	58

Supplier	Advantage
Hefei Lbao Physical & Chemical Science Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
Zhengzhou Alfa Chemical Co.,Ltd	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58

View Lastest Price from 5-Chloro-8-hydroxyquinoline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-29	Cloxiquine 130-16-5	$31.00		99.82%	10g	TargetMol Chemicals Inc.
2026-08-20	5-Chloro-8-hydroxyquinoline USP/EP/BP 130-16-5	$1.10	1g	99.9%	100 Tons min	Dideu Industries Group Limited
2026-07-27	Cloxiquine 130-16-5	$31.00		99.82%	10g	TargetMol Chemicals Inc.

Cloxiquine
130-16-5
$31.00
99.82%
TargetMol Chemicals Inc.

5-Chloro-8-hydroxyquinoline USP/EP/BP
130-16-5
$1.10
99.9%
Dideu Industries Group Limited

Cloxiquine
130-16-5
$31.00
99.82%
TargetMol Chemicals Inc.

5-Chloro-8-hydroxyquinoline Spectrum

5-Chloro-8-hydroxyquinoline(130-16-5)¹HNMR 5-Chloro-8-hydroxyquinoline(130-16-5)¹³CNMR 5-Chloro-8-hydroxyquinoline(130-16-5)IR1 5-Chloro-8-hydroxyquinoline(130-16-5)Raman

130-16-5(5-Chloro-8-hydroxyquinoline)Related Search:

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5-Chloro-8-quinolinol, >=98% 5-CHLORO-8-HYDROXYQUINOLINE 5-CHLORO-8-QUINOLINOL 5-CHLOROOXINE 5-CHLOROQUINOPHENOL Clioquinol EP Impurity A 5-Chloro-8-oxyquinoline 5-chloro-8-quinolino 5-Chloro-8-quinolol 8-Hydroxy-5-chloroquinoline Chlorisept Chloroxyquinoline Cloxyqui Cloxyquin Dermofungin Monochlorohydroxyquinoline DERMOFONGIN 5-CHLORO-8-HYDROXYQUINOLINE CRYSTALLINE 8-Quinolinol, 5-chloro- Cloxyquine 5-Chlorooxine 5-Chloro-8-quinolinol 5-Chloroquinophenol 5-Chloro-8-hydroxyqu 5-chloro-8hydroxyquninoline 5-Chloro-8-hydroxyquinoline, 95% 100GR 5-CHLORO-8-QUINOLINOL 99+% 5-CHLORO-8-HYDROXYQUINOLINE 95% Cloxiquin 5-Chloro-8-hydroxyquinoline,95% Clioquinol EP IMpurity A (Cloxyquin) Chloro-8-quinoli Clioquinol EP Impurit 5-Chloro-8-hydroxyquinoline > 5-Chloro-8-hydroxyquinoline USP/EP/BP Manufacturer Supplying High Quality?5-Chloro-8-Hydroxyquinoline CAS:?130-16-5 5-Chloro-8-hydroxyquinolineQ: What is 5-Chloro-8-hydroxyquinoline Q: What is the CAS Number of 5-Chloro-8-hydroxyquinoline Q: What is the storage condition of 5-Chloro-8-hydroxyquinoline Clioquinol Impurity 1 Ergothioneine-d3 5-Chloro-8-quinolinol, 5-Chloro-8-hydroxyquinoline Clioquinol Impurity A 5-Chloro-8-hydroxyquinoline, 98% Clioquinol EP Impurity A (Clioquinol USP Related Compound A, Cloxyquin) cloxiquine 130-16-5 C9H6NOCl Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Quinolines Hydroxyquinolines Haloquinolines Quinolines Haloquinolines Hydroxyquinolines pesticide intermediates Quinolines, Quinazolines and derivatives API 130-16-5