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7-Chloro-4-piperazinoquinoline

7-Chloro-4-piperazinoquinoline structure

CAS No.: 837-52-5

Chemical Name:: 7-Chloro-4-piperazinoquinoline

Synonyms: Compound Fr13587;BUTTPARK 50\09-11;TIMTEC-BB SBB007478;Piperaquine Impurity I;Piperaquine Impurity 6;Piperaquine Impurity A;ASINEX-REAG BAS 07566563;7-CHLORO-4-PIPERAZINOQUINOLINE;7-chloro-4-piperazinyl quinoline;7-chloro-2-piperazin-1-ylquinoline

CBNumber:: CB4443456

Molecular Formula:: C13H14ClN3

Molecular Weight:: 247.72

MDL Number:: MFCD01476123

MOL File:: 837-52-5.mol

MSDS File:: SDS

Last updated:2026-09-10 08:17:50

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7-Chloro-4-piperazinoquinoline Properties

Melting point	113-116
Boiling point	433.5±35.0 °C(Predicted)
Density	1.257±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly)
form	Solid
pka	8.62±0.50(Predicted)
color	Light Yellow to Yellow
InChI	InChI=1S/C13H14ClN3/c14-10-1-2-11-12(9-10)16-4-3-13(11)17-7-5-15-6-8-17/h1-4,9,15H,5-8H2
InChIKey	DNXNPMDUDGUXOB-UHFFFAOYSA-N
SMILES	N1C2C(=CC=C(Cl)C=2)C(N2CCNCC2)=CC=1
FDA UNII	9JZN0X101D
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P280-P301+P330+P331-P303+P361+P353

Hazard Codes

C,Xi,Xn

Risk Statements

34-22

Safety Statements

22-26-36/37/39-45

WGK Germany

WGK 3

Hazard Note

Corrosive

HazardClass

IRRITANT

HS Code

2933499090

Storage Class

11 - Combustible Solids

NFPA 704

	1
3		0

7-Chloro-4-piperazinoquinoline price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-C380330-500MG	7-Chloro-4-(piperazin-1-yl)quinoline	837-52-5	500mg	$351	2026-06-03	Buy
TRC	TRC-C380330-250MG	7-Chloro-4-(piperazin-1-yl)quinoline	837-52-5	250mg	$195	2026-06-03	Buy
Biosynth	FC42406	7-Chloro-4-piperazinylquinoline	837-52-5	5g	$900	2026-06-04	Buy
Biosynth	FC42406	7-Chloro-4-piperazinylquinoline	837-52-5	50g	$900	2026-06-04	Buy
Biosynth	FC42406	7-Chloro-4-piperazinylquinoline	837-52-5	2g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-C380330-500MG	500mg	$351	Buy
TRC-C380330-250MG	250mg	$195	Buy
FC42406	5g	$900	Buy
FC42406	50g	$900	Buy
FC42406	2g	$900	Buy

7-Chloro-4-piperazinoquinoline Chemical Properties, Uses, Production

Uses

7-Chloro-4-(piperazin-1-yl)quinoline is a metabolite of Piperaquine phosphate (P480050), a low toxicity and quick acting antimalarial drug that is used to treat malaria.

Synthesis

110-85-0

86-98-6

837-52-5

4,7-Dichloroquinoline (2.00 g, 10.1 mmol), piperazine (4.35 g, 50.5 mmol, 5.0 eq.) and triethylamine (2.81 mL, 20.2 mmol, 2.0 eq.) were added to the reaction vial. The reaction vial was sealed under nitrogen protection and heated to 130 °C. Gradual dissolution of the solid was observed to form a clarified orange-yellow solution. A yellow precipitate appeared during the reaction. The progress of the reaction was monitored by thin layer chromatography (TLC) (unfolding agent: 5% v/v dichloromethane solution of methanol) and the reaction was completed after about 4 hours. The reaction mixture was cooled to room temperature and diluted with dichloromethane (25 mL) and water (25 mL). The organic layer was separated and the aqueous layer was extracted with dichloromethane (3 x 25 mL). The organic phases were combined, washed with brine (50 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give a yellow solid crude product (2.60 g). The crude product was purified by silica gel column chromatography (eluent: dichloromethane/methanol, 100/0 to 98/2) to afford 7-chloro-4-(1-piperazinyl)quinoline (2.44 g, 9.85 mmol, 98% yield) as a yellow solid. The 1H NMR and 13C NMR data of the product were in agreement with literature reports.1H NMR (300 MHz, CDCl3): δ 8.71 (d, J = 4.9 Hz, 1H), 8.03 (d, J = 2.0 Hz, 1H), 7.95 (d, J = 9.0 Hz, 1H), 7.41 (dd, J = 2.0, 9.0 Hz, 1H), 6.82 (d, J = 2.0, 9.0 Hz, 1H), 7.41 (dd, J = 2.0, 9.0 Hz, 1H). 6.82 (d, J = 5.0 Hz, 1H), 3.17 (br s, 4H), 3.16 (br s, 4H); 13C NMR (75 MHz, CDCl3): δ 157.3, 151.9, 150.1, 134.7, 128.8, 126.0, 125.2, 121.9, 108.9, 53.5, 46.0; ESI-MS: m/z 248.

IC 50

Plasmodium

References

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 18, p. 5502 - 5505
[2] Indian Journal of Heterocyclic Chemistry, 2010, vol. 19, # 3, p. 215 - 220
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 22, p. 4360 - 4364
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 2882 - 2886
[5] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 17, p. 4733 - 4736

7-Chloro-4-piperazinoquinoline synthesis

Synthesis of 7-Chloro-4-piperazinoquinoline from Piperazine and 4,7-Dichloroquinoline

7-Chloro-4-piperazinoquinoline Preparation Products And Raw materials

Raw materials

Piperazine hexahydrate 4,7-Dichloroquinoline diethyl [(m-chloroanilino)methylene]malonate Piperazine 7-Chloroquinolin-4-ol

3-Chloroaniline

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Preparation Products

7-Chloro-4-piperazinoquinoline Suppliers

Global Suppliers ( 112)

Supplier	Tel	Email	Country	ProdList	Advantage
Zhengzhou Ruike Biochemical Technology Co., Ltd.	18521304688;17324816296	421551521@qq.com	China	280	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
China Langchem Inc.	0086-21-58956006		China	7798	57
ShangHai YuanYe Biotechnology Co., Ltd.	15026964105	shyysw007@163.com	China	4998	60
Chengdu Forest Science and Technology Development Co., Ltd.	18030648795 18030648795	sales@cdforestchem.com	China	1997	58
Nanjing Norris-Pharm Technology Co., Ltd	13901585132	sales@norris-pharm.com	China	8869	55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55
9ding chemical ( Shanghai) Limited	4009209199	sales@9dingchem.com	China	18201	56

Supplier	Advantage
Zhengzhou Ruike Biochemical Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Shanghai Hanhong Scientific Co.,Ltd.	64
Syntechem Co.,Ltd	57
China Langchem Inc.	57
ShangHai YuanYe Biotechnology Co., Ltd.	60
Chengdu Forest Science and Technology Development Co., Ltd.	58
Nanjing Norris-Pharm Technology Co., Ltd	55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	55
9ding chemical ( Shanghai) Limited	56

View Latest Price from 7-Chloro-4-piperazinoquinoline manufacturers

Update time	Product	Price	Purity	Supply Ability	Manufacturer
2026-09-10	7-Chloro-4-(piperazin-1-yl)quinoline 837-52-5	$29.00	99.72%	10g	TargetMol Chemicals Inc.
2026-08-08	7-Chloro-4-(piperazin-1-yl)quinoline 837-52-5	$29.00	99.72%	10g	TargetMol Chemicals Inc.
2025-06-10	7-Chloro-4-(piperazin-1-yl)quinoline 837-52-5	$35.00-48.00	99.52%	10g	TargetMol Chemicals Inc.

7-Chloro-4-(piperazin-1-yl)quinoline
837-52-5
$29.00
99.72%
TargetMol Chemicals Inc.

7-Chloro-4-(piperazin-1-yl)quinoline
837-52-5
$29.00
99.72%
TargetMol Chemicals Inc.

7-Chloro-4-(piperazin-1-yl)quinoline
837-52-5
$35.00-48.00
99.52%
TargetMol Chemicals Inc.

7-Chloro-4-piperazinoquinoline Spectrum

7-Chloro-4-piperazinoquinoline(837-52-5)¹HNMR

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Piperaquine Impurity I Piperaquine Phosphate Impurity Ⅰ: 7-Chloro-4-piperazinoquinoline 7-chloro-2-(1-piperazinyl)quinoline 7-chloro-2-piperazin-1-ylquinoline 7-chloro-2-piperazin-1-yl-quinoline 7-CHLORO-4-PIPERAZINOQUINOLINE 7-CHLORO-4-PIPERAZIN-1-YL-QUINOLINE TIMTEC-BB SBB007478 7-CHLORO-4-(1-PIPERAZINYL)QUINOLINE 7-Chloro-4-piperazin-1-ylquinoline 97% 7-chloro-4-piperazinyl quinoline ASINEX-REAG BAS 07566563 BUTTPARK 50\09-11 1-(7-Chloroquinolin-4-yl)piperazine PiperaquinePhosphateRelatedCoMpoundA(7-Chloro-4-(piperazin-1-yl)quinoline) Quinoline, 7-chloro-4-(1-piperazinyl)- Piperaquine Impurity 6 Piperaquine Impurity A 7-chloro-4-(piperazin-1-yl)quinolineQ: What is 7-chloro-4-(piperazin-1-yl)quinoline Q: What is the CAS Number of 7-chloro-4-(piperazin-1-yl)quinoline Q: What is the storage condition of 7-chloro-4-(piperazin-1-yl)quinoline Q: What are the applications of 7-chloro-4-(piperazin-1-yl)quinoline Compound Fr13587 Piperaquine Impurity 6 (7-Chloro-4-Piperazinylquinoline) Piperaquine Phosphate Impurity Ⅰ: 7-Chloro-4-piperazinoquinoline 837-52-5