Piperaquinoline
- CAS No.
- 4085-31-8
- Chemical Name:
- Piperaquinoline
- Synonyms
- piperaquinoline;Piperaquine phosphate;PIRERAQUINE PHOSPHATE;pipieraquine phosphate;4,4'-(1,3-Propanediyldi-4;Piperaquinoline USP/EP/BP;Piperaquine phosphate CP2000;BULK DRUG: PIPERAQUINE PHOSPHATE (DMF GRADE);1,3-Bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)propane;4,4'-(trimethylenedi-4,1-piperazinediyl)bis(7-chloro-quinoline)
- CBNumber:
- CB9744930
- Molecular Formula:
- C29H32Cl2N6
- Molecular Weight:
- 535.51
- MDL Number:
- MFCD01237079
- MOL File:
- 4085-31-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 198-200 °C |
|---|---|
| Boiling point | 721.1±60.0 °C(Predicted) |
| Density | 1.292±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≤0.2mg/ml in DMSO |
| form | crystalline solid |
| pka | 8.92±0.50(Predicted) |
| InChIKey | UCRHFBCYFMIWHC-UHFFFAOYSA-N |
| SMILES | C(N1CCN(C2C3C(N=CC=2)=CC(Cl)=CC=3)CC1)CCN1CCN(C2C3C(N=CC=2)=CC(Cl)=CC=3)CC1 |
| FDA UNII | A0HV2Q956Y |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Piperaquinoline price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20799 | Piperaquine ≥98% | 4085-31-8 | 10mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 20799 | Piperaquine ≥98% | 4085-31-8 | 25mg | $316 | 2026-04-30 | Buy |
| Cayman Chemical | 20799 | Piperaquine ≥98% | 4085-31-8 | 50mg | $598 | 2026-04-30 | Buy |
| Cayman Chemical | 20799 | Piperaquine ≥98% | 4085-31-8 | 100mg | $1127 | 2026-04-30 | Buy |
| Usbiological | 287611 | Piperaquine tetraphosphate tetrahydrate Asreported | 4085-31-8 | 5g | $340 | 2026-06-03 | Buy |
Piperaquinoline Chemical Properties,Uses,Production
Chemical Properties
To class white crystalline powder
Uses
Antimalarial drugs.
Definition
ChEBI: An aminoquinoline that is 1,3-di(piperazin-1-yl)propane in which the nitrogen at position 4 of each of the piperazine moieties is replaced by a 7-chloroquinolin-4-yl group.
Biological Activity
piperaquine, an antimalarial drug, is first synthesised in the 1960s and extensively used as prophylaxis and treatment during the next 20 years.
in vitro
in 280 p. falciparum isolates, the ic50 for piperaquine ranged from 9.8 nm to 217.3 nm and a significant but low correlation was observed between the ic50 values for piperaquine and chloroquine. however, the coefficient of determination indicated that only 2.1% of the variation in the response to piperaquine was explained by the variation in the response to chloroquine. moreover, the mean value for piperaquine was 74.0 nm in the pfcrt k76 wild-type group and 87.7 nm in the 76t mutant group and such difference was not significant [1].
in vivo
male sd rats were orally administered piperaquine or as a short-term i.v. infusion. results showed that piperaquine disposition was best described by a 3-compartment model with a rapid initial distribution phase after i.v. administration. the pk of piperaquine was characterized by a low clearance, a large volume of distribution and a long terminal half-life [2].
IC 50
9.8 to 217.3 nm for p. falciparum isolates
References
[1] pascual a et al. in vitro piperaquine susceptibility is not associated with the plasmodium falciparum chloroquine resistance transporter gene. malar j. 2013 nov 25;12:431.
[2] tarning j, lindegardh n, sandberg s, day nj, white nj, ashton m. pharmacokinetics and metabolism of the antimalarial piperaquine after intravenous and oral single doses to the rat. j pharm sci. 2008 aug;97(8):3400-10.
[3] denis mb, davis tm, hewitt s, incardona s, nimol k, fandeur t, poravuth y, lim c, socheat d. efficacy and safety of dihydroartemisinin-piperaquine (artekin) in cambodian children and adults with uncomplicated falciparum malaria. clin infect dis. 2002 dec 15;35(12):1469-76.
Piperaquinoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6746 | 52 |
| Beijing Isomersyn Technology CO;LTD | 010-82954736 13391601435 | sales@isomersyn.com | China | 3294 | 57 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Wuhan Fortuna Chemical Co., Ltd | 027-59207852 13308628970 | buy@fortunachem.com | China | 2698 | 58 |
| Cantotech Chemicals, Ltd. | 86-0755-86635001 | cantotech@126.com | China | 4554 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
View Lastest Price from Piperaquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Piperaquinoline USP/EP/BP
4085-31-8
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-07-20 | Piperaquine
4085-31-8
|
$415.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2026-05-28 | Piperaquine Phosphate
4085-31-8
|
$10.00 | 1kg | 98% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Piperaquinoline USP/EP/BP
4085-31-8
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Piperaquine
4085-31-8
- $415.00
- TargetMol Chemicals Inc.
-
- Piperaquine Phosphate
4085-31-8
- $10.00
- 98%
- Hebei Chuanghai Biotechnology Co,.LTD
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