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D(+)-Trehalose dihydrate

D(+)-Trehalose dihydrate Structure
D(+)-Trehalose dihydrate structure
CAS No.
6138-23-4
Chemical Name:
D(+)-Trehalose dihydrate
Synonyms
TREHALOSE DIHYDRATE;D-TREHALOSE;D-TREHALOSE DIHYDRATE;D-(+)-TREHALOSE DIHYDRATE;Haizaotang;D(+)-TREHALOSE;Trehalose (hydrate);α,α-Trehalose dihydrate;ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GLUCOPYRANOSIDE DIHYDRATE;Trehalose 99
CBNumber:
CB4454890
Molecular Formula:
C12H22O11·2H2O
Molecular Weight:
378.33
MDL Number:
MFCD00071594
MOL File:
6138-23-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-22 10:47:44
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D(+)-Trehalose dihydrate Properties

Melting point 97-99 °C(lit.)
alpha 179 º (c=2, H2O)
Boiling point 115.3 °C
FEMA 4600 | TREHALOSE, DIHYDRATE
refractive index 181 ° (C=7, H2O)
storage temp. room temp
solubility H2O: 50 mg/mL
form powder
color White to Off-White
biological source Saccharomyces cerevisiae
optical activity [α]20/D +179±3°, c = 2% in H2O
Water Solubility 68.9 g/100 mL (20 ºC)
Sensitive Hygroscopic
Merck 14,9580
BRN 5322018
InChI 1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1
InChIKey DPVHGFAJLZWDOC-NYAOJISMSA-N
SMILES [H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
CAS DataBase Reference 6138-23-4(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) TREHALOSE, DIHYDRATE
FDA UNII 7YIN7J07X4
UNSPSC Code 41116107
NACRES NA.85

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  38-36/37/38
Safety Statements  37/39-26-24/25
WGK Germany  2
RTECS  LZ5776547
F  3-10
TSCA  Yes
HS Code  29400000
Storage Class 11 - Combustible Solids
NFPA 704
1

D(+)-Trehalose dihydrate price More Price(126)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001172 Trehalose dihydrate European Pharmacopoeia (EP) Reference Standard 6138-23-4 250 mg $254 2026-04-30 Buy
Sigma-Aldrich 90210 D-(+)-Trehalose dihydrate for microbiology, ≥99.0% 6138-23-4 50g $271 2026-04-30 Buy
Sigma-Aldrich 625625 Trehalose, Dihydrate - CAS 6138-23-4 - Calbiochem Non-reducingdisaccharidewhichyields2molesofD-glucoseuponacidhydrolysis 6138-23-4 50g $123 2026-04-30 Buy
Sigma-Aldrich 1673715 Trehalose United States Pharmacopeia (USP) Reference Standard 6138-23-4 400mg $564 2026-04-30 Buy
Sigma-Aldrich 1.02776 Trehalose dihydrate EMPROVE? EXPERT, Ph. Eur., ChP, NF, JP 6138-23-4 1KG $1140 2026-04-30 Buy
Product number Packaging Price Buy
Y0001172 250 mg $254 Buy
90210 50g $271 Buy
625625 50g $123 Buy
1673715 400mg $564 Buy
1.02776 1KG $1140 Buy

D(+)-Trehalose dihydrate Chemical Properties,Uses,Production

Description

Trehalose is a natural non-reducing disaccharide composed of two α-glucose units. It is found in all major groups of organisms except vertebrates, has biological functions as an osmolyte, storage reserve, and stress protectant, and has diverse commercial applications. Trehalose can also induce or enhance autophagy.

Chemical Properties

D(+)-Trehalose dihydrate occurs as virtually odorless, white or almost white crystals with a sweet taste (approximately 45% of the sweetness of sucrose).

Uses

Stabilizes cells during freezing, freeze-drying and air-drying. Sweetener and stabilizer in foods; cryoprotectant for freeze-dried foods. Additive in cosmetics and personal care products.

Uses

D(+)-Trehalose dihydrate is used in many processed foods as well as in biopharmaceutical monoclonal antibody formulations, it is also used as a protein stabilize.

Production Methods

Trehalose is prepared from liquefied starch by a multistep enzymatic process. The commercial product is the dihydrate.

Pharmaceutical Applications

D(+)-Trehalose dihydrate is used for the lyoprotection of therapeutic proteins, particularly for parenteral administration. Other pharmaceutically relevant applications include use as an excipient for diagnostic assay tablets; for stabilization during the freeze–thaw and lyophilization of liposomes; and for stabilization of blood cells, cosmetics, and monoclonal antibodies. Trehalose may also be used in formulations for topical application.

Biochem/physiol Actions

D(+)-Trehalose dihydrate is a non-reducing sugar formed from two glucose units joined by a 1-1 alpha bond. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.

Safety

Trehalose is used in cosmetics, foods, and parenteral and nonparenteral pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient.
In the gut, trehalose is rapidly metabolized to glucose by the specific enzyme trehalase. A small minority of the population exhibits a primary (hereditary) or secondary (acquired) trehalase deficiency and thus may experience intestinal discomfort after ingestion of excessive amounts of trehalose owing to the osmotic activity of undigested trehalose in the gut. However, smaller amounts of trehalose are tolerated by such individuals without any symptoms.
Trehalose is used as a sweetener and is reported to have substantially less cariogenic potential than sucrose.
LD50 (dog, IV): >1 g/kg
LD50 (dog, oral): >5 g/kg
LD50 (mouse, IV): >1 g/kg
LD50 (mouse, oral): >5 g/kg
LD50 (rat, IV): >1 g/kg
LD50 (rat, oral): >5 g/kg

Source

D(+)-Trehalose dihydrate is a natural alpha-linked disaccharide that is also referred to as mycose or tremalose. It is found naturally in plants and microorganisms such as grasshoppers, shrimp, butterflies and bees.

storage

Trehalose is a relatively stable material. At 60°C for 5 hours it loses not more than 1.5% w/w of water (the dihydrate water of crystallization is retained). Open stored powder may liquefy at high relative humidity (≥90%).
Trehalose should be stored in a cool, dry place in a well-sealed container.

Purification Methods

α,α-D(+)-Trehalose crystallises (as the dihydrate) from aqueous EtOH. Dry it at 13o. For the anhydrous compound dissolve 10g in pyridine (200mL) and distil off this solvent at atmospheric pressure, and when the temperature rises to 115.3o all the H2O is removed and 73mL of distillate is collected. Most of the anhydrous material crystallises out at this stage. The crystals are collected (6.8g), washed with Et2O to give 6.1g of anhydrous product. Higher yields are obtained by slightly more prolonged distillation. [Birch J Chem Soc 3489 1965, X-ray cryst: Brown et al. Acta Cryst 28 3145 1972, Beilstein 17/8 V 3.]

Incompatibilities

D(+)-Trehalose dihydrate is incompatible with strong oxidizing agents, especially in the presence of heat.

Regulatory Status

GRAS listed. In the UK trehalose may be used in certain food applications. Included in parenteral and nonparenteral investigational formulations.

References

[1] CARLOS M FIGUEROA J E L. A Tale of Two Sugars: Trehalose 6-Phosphate and Sucrose.[J]. Plant Physiology, 2016, 172 1: 7-27. DOI: 10.1104/pp.16.00417
[2] O J GODDIJN. Inhibition of trehalase activity enhances trehalose accumulation in transgenic plants.[J]. Plant Physiology, 1997, 113 1: 181-190. DOI: 10.1104/pp.113.1.181
[3] MAARTEN WALMAGH T D Renfei Zhao. Trehalose Analogues: Latest Insights in Properties and Biocatalytic Production.[J]. International Journal of Molecular Sciences, 2015, 16 6: 13729-13745. DOI: 10.3390/ijms160613729
[4] SAEID GHAVAMI . Autophagy and apoptosis dysfunction in neurodegenerative disorders[J]. Progress in Neurobiology, 2014, 112: Pages 24-49. DOI: 10.1016/j.pneurobio.2013.10.004

D(+)-Trehalose dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

D(+)-Trehalose dihydrate Suppliers

Global( 646)Suppliers
Supplier Tel Email Country ProdList Advantage
AVT(Shanghai) Pharmaceutical Tech Co., Ltd. 021-58876118 15692161719 avt013@avt-cn.com China 97 58
QINGDAO WANYUAN MOUNTAIN BIOTECH CO.,LTD 0532-0532-66720179 15092119928 cuiningning@bionutrichem.com China 71 58
Spec-Chem Industry Inc. 025-84523390 13505162978 sc@specchemind.com China 123 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Shanghai Yikefan Biotechnology Co., LTD 18221419461; 18221419461 sales@yikefan.com China 612 58
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Hubei wei shi reagent group ltd., company 027-59102966 18717199209 2853877583@qq.com China 2896 58
SHANGHAI YUANJU BIO-TECH CO., LTD 62750277 15618798178 362310313@qq.com China 469 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Supplier Advantage
AVT(Shanghai) Pharmaceutical Tech Co., Ltd. 58
QINGDAO WANYUAN MOUNTAIN BIOTECH CO.,LTD 58
Spec-Chem Industry Inc. 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai Yikefan Biotechnology Co., LTD 58
Shandong Xiya Chemical Co., Ltd 57
Hubei wei shi reagent group ltd., company 58
SHANGHAI YUANJU BIO-TECH CO., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62

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View Lastest Price from D(+)-Trehalose dihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
D(+)-Trehalose dihydrate pictures 2026-09-13 D(+)-Trehalose dihydrate
6138-23-4
 0.99 RongNa Biotechnology Co.,Ltd
D(+)-Trehalose dihydrate pictures 2026-09-11 D(+)-Trehalose dihydrate
6138-23-4
 $666.00-999.00 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
D(+)-Trehalose dihydrate pictures 2026-09-11 D(+)-Trehalose dihydrate
6138-23-4
 1KG 98.0% 500kg/month WUHAN FORTUNA CHEMICAL CO., LTD

D(+)-Trehalose dihydrate Spectrum

D(+)-Trehalose dihydrate(6138-23-4)1HNMRD(+)-Trehalose dihydrate(6138-23-4)RamanD(+)-Trehalose dihydrate(6138-23-4)IRD(+)-Trehalose dihydrate(6138-23-4)FT-IR

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D-ALPHA,ALPHA-TREHALOSE DIHYDRATE D(+)TREHALOSE DIHYDRATE CELL*CULTURE TES TED D(+)-TREHALOSE DIHYDRATE, FOR MICRO-BIOL OGY .alpha.-D-Glucopyranoside, .alpha.-D-glucopyranosyl, dihydrate d(+)-trehalose dihydrate, mycose a,a-D-Trehaloseendotoxinfree D-(+)-TREHALOSE,DIHYDRATE,POTATO D-TREHALOSE DIHYDRATE extrapure CHR α,α-Trehalose, D-(+)-Trehalose dihydrate, α-D-Glucopyranosyl-α-D-glucopyranoside α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside D(+)-Trehalose dihydrate 99% Trehalose·2hydrate α,α-Trehalose·2hydrate α-D-Glucopyranosyl α-D-glucopyranoside·dihydrate A-D-GLUCOPYRANOSYL-A-D-GLUCOPYRANOSIDE DIHYDRATE D-(+)-TREHALOSE DIHYDATE D-TREHALOSE.2H2OANALYTICAL GRADE D-(+)-Trehalose dihydrate,α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside D(+)-Trehalose dihyd D(+)-Trehalose dihydrate,99% Trehalose (400 mg) TREHALOSE DIHYDRATE, D-(+)-(RG) Trehalose dihydrat a-D-Glucopyranoside, a-D-glucopyranosyl, hydrate (1:2) D(+)-Trehalose dihydrate (for injection) D-(+)-Trehalose dihydrate (D-Trehalose dihydrate D-(+)-Trehalose dihydrate (Synonyms: D-Trehalose dihydrate ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GLUCOPYR 1-O-ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GLUCOPYRANOSIDE DIHYDRATE A,A-TREHALOSE DIHYDRATE A,A-D-TREHALOSE DIHYDRATE A-D-GLUCOPYRANOSYL-A-D-GLUCOPYRANOSIDE ALPHA-D-GLUCOPYRANOSIDE DIHYDRATE ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GLUCOPYRANOSIDE ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GLUCOPYRANOSIDE DIHYDRATE ALPHA-D-GLUCOPYRANOSYL DIHYDRATE ALPHA,ALPHA-D-TREHALOSE DIHYDRATE ALPHA,ALPHA-TREHALOSE DIHYDRATE MYCOSE DIHYDRATE TREHALOSE, D-(+)- alpha-D-Glucopypranosyl-alpha-D-glucopyranoside α-D-Glucopyranosyl-α-D-glucopyranoside D-(+)-TREHALOSE DIHYDRATE FROM*SACCHAROM YCES CEREVI D(+)TREHALOSE REDUCED METAL ION CONTENT DIHYDRATE Trehalose Dihydrate,D(+)-Trehalose dihydrate D-(+)-Trehalose dihydrate Vetec(TM) reagent grade, >=99% MAGNESIUM 1000PPM FOR ICP-MS PHOSPHORIC ACID 150 ML/L a,a-D-Trehalose dihydrate endotoxin free D-(+)-TREHALOSE DIHYDRATE, FROM STAR D(+)TREHALOSE REDUCED METAL ION CONT Trehalose (hydrate) D-(+)-Trehalose dihydrate, from Saccharomyces cerevisiae D-(+)-Trehalose Dihydrate> Trehalose 99 Trehalose dihydrate CRS Trehalose, Endotoxin Free Trehalose (for injection)