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D(+)-Malic acid

D(+)-Malic acid Structure
D(+)-Malic acid structure
CAS No.
636-61-3
Chemical Name:
D(+)-Malic acid
Synonyms
D-MALIC ACID;D-(+)-MALIC ACID;(R)-MALIC ACID;(2R)-2-Hydroxybutanedioic acid;D-(+)-MaL;D(+)-Malic;D-APPLE ACID;(R)-malicaci;l(+)-malicaci;D-Aepfelsaeure
CBNumber:
CB9373789
Molecular Formula:
C4H6O5
Molecular Weight:
134.09
MDL Number:
MFCD00004245
MOL File:
636-61-3.mol
MSDS File:
SDS
Last updated:2026-04-22 18:57:36
Product description Number Pack Size Price
D-(+)-Malic acid unnatural form, ≥97.0% (T) 02300 1g $62.2
D-(+)-Malic acid for the resolution of racemates for synthesis 8.00763 5G $131
D-(+)-Malic acid unnatural form, ≥97.0% (T) 02300 5g $91.5
D-Malic acid analytical standard 46940-U 1kit $38.7
D-(+)-Malic Acid >98.0%(GC)(T) M0021 5g $22
More product size
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D(+)-Malic acid Properties

Melting point 98-102 °C (lit.)
alpha 2.2 º (c=3, H2O)
Boiling point 167.16°C (rough estimate)
bulk density 600kg/m3
Density 1.60
refractive index 6.5 ° (C=10, Acetone)
storage temp. Store below +30°C.
solubility Soluble in methanol, ethanol, acetone, ether.
pka 3.61±0.23(Predicted)
form Crystalline Powder
color White
PH 2.2 (10g/l, H2O, 20℃)
optical activity [α]20/D +28.0±2°, c = 5.5% in pyridine
Water Solubility soluble
Merck 14,5707
BRN 1723540
InChI 1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/t2-/m1/s1
InChIKey BJEPYKJPYRNKOW-UWTATZPHSA-N
SMILES O[C@H](CC(O)=O)C(O)=O
LogP -1.370 (est)
CAS DataBase Reference 636-61-3(CAS DataBase Reference)
FDA UNII P750Y95K96
NIST Chemistry Reference (r)-Hydroxybutanedioic acid(636-61-3)
UNSPSC Code 85151701
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Danger
Hazard statements  H315-H318-H335
Precautionary statements  P261-P280-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  37/38-41-36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  ON7260000
HS Code  29181980
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Dam. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

D(+)-Malic acid price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 02300 D-(+)-Malic acid unnatural form, ≥97.0% (T) 636-61-3 1g $62.2 2026-03-19 Buy
Sigma-Aldrich 8.00763 D-(+)-Malic acid for the resolution of racemates for synthesis 636-61-3 5G $131 2026-03-19 Buy
Sigma-Aldrich 02300 D-(+)-Malic acid unnatural form, ≥97.0% (T) 636-61-3 5g $91.5 2026-03-19 Buy
Sigma-Aldrich 46940-U D-Malic acid analytical standard 636-61-3 1kit $38.7 2026-03-19 Buy
TCI Chemical M0021 D-(+)-Malic Acid >98.0%(GC)(T) 636-61-3 5g $22 2026-03-19 Buy
Product number Packaging Price Buy
02300 1g $62.2 Buy
8.00763 5G $131 Buy
02300 5g $91.5 Buy
46940-U 1kit $38.7 Buy
M0021 5g $22 Buy

D(+)-Malic acid Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid rece

Uses

D-(+)-Malic acid used as an acidulant and flavoring agent, food additive. And it is also used in the place of the less sour citric acid in sour sweets.

Uses

D-(+)-Malic acid can be used:

  • As a starting material for the enantioselective total synthesis of ()-erinapyrone B.
  • As a chiral organocatalyst in the synthesis of α-aminophosphonates from various aldehydes, aniline, and diethyl phosphite.

Definition

ChEBI: An optically active form of malic acid having (R)-configuration.

Biological Activity

D-(+)-Malic acid, an active isomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport.

Synthesis

Malic acid is isolated from immature apples; industrially prepared is obtained by catalytic oxidation of benzene, then reacting with water at high temperature and high pressure to generate maleic anhydride.

in vitro

Some bacteria belonging to Arthrobacter, Brevibacterium, Corynebacterium, Pseudomonas, Bacillus, and Acinetobacter produced D-(+)-Malic acid (D-Malic acid) from Maleic acid when the cells grown in a medium containing citraconic acid are reacted aerobically with Maleic acid in the pH 7.0 phosphate buffer containing 0.1% sodium chloride.

D(+)-Malic acid synthesis

56-84-8
636-61-3
4198-33-8
6915-18-0
Synthesis of D(+)-Malic acid from L-Aspartic acid

D(+)-Malic acid Preparation Products And Raw materials

Raw materials

Butanoic acid, 4,4,4-trichloro-3-hydroxy-, (R)- (9CI) MALEIC ACID (S)-2-CHLOROSUCCINIC ACID CHLOROSUCCINIC ACID L-Aspartic acid
DL-Malic acid Oxaloacetic acid Fumaric acid L-Asparagine L(+)-Tartaric acid
Maleic acid L-Malic acid

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Preparation Products

(R)-(-)-3-Pyrrolidinol hydrochloride (S)-(+)-3-Quinuclidinol (R)-3-Hydroxypyrrolidine (R)-(+)-1-Benzyl-3-pyrrolidinol 2-Butenoic acid, 4-hydroxy-2-methyl-, (E)- (9CI)
DIISOPROPYL (R)-(+)-MALATE

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D(+)-Malic acid Suppliers

Global( 520)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing New Thinking Chem Co.,Ltd
+8615896017193 nanjingxinsi@163.com China 217 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5235 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649 sarah@tnjone.com China 1143 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 880 50
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13815 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21592 55
Speranza Chemical Co., Ltd. 		+86-86-075521030354 +8618688942810 sophieliu@speranzachem.com China 923 55
Supplier Advantage
Nanjing New Thinking Chem Co.,Ltd
58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Speranza Chemical Co., Ltd. 		55

Related articles

View Lastest Price from D(+)-Malic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
D( )Malic acid pictures 2026-04-23 D( )Malic acid
636-61-3
 US $0.00-0.00 / KG 5KG 99% 500kg Speranza Chemical Co., Ltd.
D(+)-Malic acid pictures 2026-04-23 D(+)-Malic acid
636-61-3
 US $0.00 / KG 1KG 98.0% 1000kg/month WUHAN FORTUNA CHEMICAL CO., LTD
D-(+)-Malic acid pictures 2026-04-22 D-(+)-Malic acid
636-61-3
 US $29.00 / mL 99.85% 10g TargetMol Chemicals Inc.
  • D( )Malic acid pictures
  • D( )Malic acid
    636-61-3
  • US $0.00-0.00 / KG
  • 99%
  • Speranza Chemical Co., Ltd.

D(+)-Malic acid Spectrum

D(+)-Malic acid(636-61-3)1HNMRD(+)-Malic acid(636-61-3)IR1

636-61-3(D(+)-Malic acid)Related Search:

Folic acid D(-)-Tartaric acid Disodium succinate L-Malic acid 2,3-Dibromosuccinic acid
Succimer Hyaluronic acid Ethyl 2-(Chlorosulfonyl)acetate Diethyl succinosuccinate Malic acid
Succinic acid DL-Malic acid D(+)-Trehalose dihydrate 4-Hydroxy-D-(-)-2-phenylglycine ZINC ZIRCONATE
Citric acid Oxaloacetic acid 3,4-dihydroxybutanoic acid

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Butanedioic acid, hydroxy-, (R)- hydroxy-,(R)-Butanedioicacid l(+)-malicaci (R)-(+)-MALIC ACID (R)-MALIC ACID Malic Acid Impurity 3 (2R)-2-hydroxybutanedioate (+)-D-MALIC ACID D-(+)-APPLE ACID D-APPLE ACID MALIC ACID, D-(+)- (r)-hydroxybutanedioic acid (R)-(+)-HYDROXYSUCCINIC ACID (R)-HYDROXYSUCCINIC ACID (R)-2-HYDROXY-SUCCINIC ACID R(+)-2-HYDROXYSUCCINIC ACID (R)-2-HYDROXYBUTANEDICARBOXYLIC ACID D-MALIC ACID 100MG NEAT D-(+)-MALIC ACID 99% D-(+)-Malic acid, 98+% D-Aepfelsaeure D(+)-Malic Butanedioic acid, hydroxy-, (2R)- MALIC ACID, D-(+)-(P) D-MALIC ACID / (R)-(+)-HYDROXYSUCCINIC ACID D-HYDROXYBUTANEDIOIC ACID D-HYDROXYSUCCINIC ACID D-(+)-Malic acid ,99% D-(+)-Malic acid,(R)-(+)-2-Hydroxysuccinic acid, D-Hydroxybutanedioic acid D-(+)-MALIC ACID FOR THE RESOLUTION OF R (R)-(+)-2-Hydroxysuccinic acid, D-(+)-Malic acid, D-Hydroxybutanedioic acid (R)-(+)-2-Hydroxysuccinic acid, D-Hydroxybutanedioic acid (2R)-Malic acid D-(+)-2-Hydroxysuccinic acid [R,(+)]-2-Hydroxybutanedioic acid D-(+)-Malic acid unnatural forM, >=97.0% (T) D-(+)-Malic Acid, 97+% Butanedioic acid, 2-hydroxy-, (2R)- D-(+)-MalicAcid> D-(+)-MaL (R)-malicaci dextro-malic acid (+)-Malic acid abozantinib Impurity D-(+)-Malic acid, 10 mM in DMSO D-Malic acid (R)-2-Hydroxysuccinic acid (Cabozantinib Impurity) D-(+)-MALIC ACID D-MALIC ACID (2R)-2-Hydroxybutanedioic acid 636-61-3 480-40-4 Asymmetric Synthesis Optical Resolution Chiral Building Blocks Carboxylic Acids (Chiral) for Resolution of Bases Chiral Resolution Reagents