Ethyl thiazole-4-carboxylate
- CAS No.
- 14527-43-6
- Chemical Name:
- Ethyl thiazole-4-carboxylate
- Synonyms
- 4-ThiazoL;4-Ethoxycarbonylthiazole;Ethyl 4-Thiazolecarboxylate;Ethyl thiazole-4-carboxylate;4-(Ethoxycarbonyl)-1,3-thiazole;ETHYL 1,3-THIAZOLE-4-CARBOXYLATE;2-ethyl-1,3-thiazole-4-carboxylate;Ethyl 1,3-thiazole-4-carboxylate 98%;4-Thiazolecarboxylic Acid Ethyl Ester;Ethyl thiazole-
4- carboxylate
- CBNumber:
- CB4459305
- Molecular Formula:
- C6H7NO2S
- Molecular Weight:
- 157.19
- MDL Number:
- MFCD03788566
- MOL File:
- 14527-43-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 42-44 |
|---|---|
| Boiling point | 130°C 12mm |
| Density | 1.242±0.06 g/cm3(Predicted) |
| Flash point | >110℃ |
| storage temp. | 2-8°C |
| solubility | Chloroform, Dichloromethane, Ether, Ethyl Acetate |
| form | Solid |
| pka | 0.38±0.10(Predicted) |
| color | Pale-Yellow Crystalline |
| InChI | 1S/C6H7NO2S/c1-2-9-6(8)5-3-10-4-7-5/h3-4H,2H2,1H3 |
| InChIKey | XDOKFEJMEJKVGX-UHFFFAOYSA-N |
| SMILES | CCC(=O)c1cscn1 |
| CAS DataBase Reference | 14527-43-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 2934100090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
Ethyl thiazole-4-carboxylate price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 707112 | Ethyl 4-thiazolecarboxylate 97% | 14527-43-6 | 500mg | $33.1 | 2023-06-20 | Buy |
| Usbiological | 011815 | Ethyl 4-Thiazolecarboxylate | 14527-43-6 | 1g | $425 | 2026-06-03 | Buy |
| AstaTech | CL2512 | ETHYLTHIAZOLE-4-CARBOXYLATE 97% | 14527-43-6 | 1G | $30 | 2026-04-30 | Buy |
| Activate Scientific | AS50078 | Ethyl thiazole-4-carboxylate 97% | 14527-43-6 | 1g | $23 | 2026-06-04 | Buy |
| Activate Scientific | AS50078 | Ethyl thiazole-4-carboxylate 97% | 14527-43-6 | 5g | $41 | 2026-06-04 | Buy |
Ethyl thiazole-4-carboxylate Chemical Properties, Uses, Production
Chemical Properties
Pale-Yellow Crystalline Solid
Uses
Ethyl 4-Thiazolecarboxylate (cas# 14527-43-6) is a compound useful in organic synthesis.
Synthesis Reference(s)
Synthesis, p. 681, 1976 DOI: 10.1055/s-1976-24156
Synthesis
3973-08-8
64-17-5
14527-43-6
The general procedure for the synthesis of ethyl 4-thiazolecarboxylate from thiazole-4-carboxylic acid and ethanol was as follows: 2.5 mmol of thiazole-4-carboxylic acid and 2.0 mmol of ethanol were dissolved in 25 mL of dry dichloromethane (DCM) in a dry flask with continuous stirring. Subsequently, 2.5 mmol of 3-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride (EDC-HCl) was added. After the temperature of the reaction system was lowered to 0 °C, 0.2 mmol of 4-dimethylaminopyridine (DMAP) was added slowly dropwise and the reaction was continued at 0 °C. After completion of the reaction, the temperature of the system was raised to room temperature and the reaction was continued with stirring for 4 hours. Upon termination of the reaction, 25 mL of saturated sodium bicarbonate (NaHCO3) solution was added and extracted twice with dichloromethane (2 x 20 mL). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product. Finally, the crude product was purified by column chromatography (eluent ratio: ethyl acetate:petroleum ether=1:5) to obtain the target compound ethyl 4-thiazolecarboxylate.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 64 - 73
Ethyl thiazole-4-carboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cangzhou Huiying Pharmaceutical Technology Co. , Ltd. | 15532866377 | 294989518@qq.com | China | 31 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. | 21-54820552 17702105771 | 188738128@qq.com | China | 300 | 66 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
View Latest Price from Ethyl thiazole-4-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | ETHYL THIAZOLE-4-CARBOXYLATE
14527-43-6
|
$8.00 | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- ETHYL THIAZOLE-4-CARBOXYLATE
14527-43-6
- $8.00
- 98%
- Career Henan Chemical Co
14527-43-6 (Ethyl thiazole-4-carboxylate) Related Search:
1of4
