4-Hydroxymethylthiazole
- CAS No.
- 7036-04-6
- Chemical Name:
- 4-Hydroxymethylthiazole
- Synonyms
- 4-Thiazolemethanol;THIAZOLE-4-METHANOL;4-Hydroxymethylthiaz;4-HYDROXYMETHYLTHIAZOLE;1,3-THIAZOL-4-YLMETHANOL;4-(Hydroxymethyl)-1,3-thiazole;4-(Hydroxymethyl)-1,3-thiazole95%;4-(Hydroxymethyl)-1,3-thiazole 95%;4-HydroxyMethylthiazole CAS7036-04-6
- CBNumber:
- CB9672002
- Molecular Formula:
- C4H5NOS
- Molecular Weight:
- 115.15
- MDL Number:
- MFCD04115728
- MOL File:
- 7036-04-6.mol
- MSDS File:
- SDS
| Melting point | 112-114 °C(Solv: ethyl ether (60-29-7); ethanol (64-17-5)) |
|---|---|
| Boiling point | 85-90/0.5mm |
| Density | 1.339±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | liquid |
| pka | 13.21±0.10(Predicted) |
| color | colourless |
| InChI | InChI=1S/C4H5NOS/c6-1-4-2-7-3-5-4/h2-3,6H,1H2 |
| InChIKey | WQVOUANKVCYEIQ-UHFFFAOYSA-N |
| SMILES | S1C=C(CO)N=C1 |
| CAS DataBase Reference | 7036-04-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 37/38-41 |
| Safety Statements | 26-39 |
| Hazard Note | Irritant |
| HS Code | 2934100090 |
4-Hydroxymethylthiazole price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 069454 | 4-(Hydroxymethyl)thiazole 97% | 7036-04-6 | 1g | $72 | 2021-12-16 | Buy |
| Apolloscientific | OR5598 | 4-(Hydroxymethyl)-1,3-thiazole 95% | 7036-04-6 | 1g | $145 | 2021-12-16 | Buy |
| SynQuest Laboratories | 8H01-1-04 | 4-(Hydroxymethyl)-1,3-thiazole 95% | 7036-04-6 | 1g | $160 | 2021-12-16 | Buy |
| AK Scientific | X0268 | 4-Hydroxymethylthiazole | 7036-04-6 | 5g | $289 | 2021-12-16 | Buy |
| Apolloscientific | OR5598 | 4-(Hydroxymethyl)-1,3-thiazole 95% | 7036-04-6 | 5g | $363 | 2021-12-16 | Buy |
4-Hydroxymethylthiazole Chemical Properties,Uses,Production
Chemical Properties
Off-yellow oily liquid
Synthesis
14527-43-6
7036-04-6
The general procedure for the synthesis of 4-hydroxymethylthiazole from ethyl 4-thiazolecarboxylate was as follows: - Lithium aluminum hydride (1M tetrahydrofuran solution, 1.5 mL) was slowly added dropwise to a stirred tetrahydrofuran solution (4 mL) of ethyl 4-thiazolecarboxylate (224 mg) at 0 °C. - The reaction mixture was naturally warmed to room temperature with stirring for 1 hour. - Ethyl acetate (20 mL), water (1 mL), 2M sodium hydroxide solution (2 mL), and water (3 mL) were added sequentially to the reaction mixture. - The precipitate formed was removed by filtration through diatomaceous earth (iT). - The filtrate was concentrated to give 4-hydroxymethylthiazole (150 mg, 92% yield). - Nuclear magnetic resonance hydrogen spectroscopy (DMSO-d6) data: δ 4.12 (s, 2H), 7.47 (s, 1H), 9.03 (s, 1H).
References
[1] Patent: WO2005/61465, 2005, A1. Location in patent: Page/Page column 62
[2] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 367 - 391
4-Hydroxymethylthiazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10242 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
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