ChemicalBook >> CAS DataBase List >>4-Hydroxymethylthiazole

4-Hydroxymethylthiazole

4-Hydroxymethylthiazole structure

CAS No.: 7036-04-6

Chemical Name:: 4-Hydroxymethylthiazole

Synonyms: 4-Thiazolemethanol;THIAZOLE-4-METHANOL;4-Hydroxymethylthiaz;4-HYDROXYMETHYLTHIAZOLE;1,3-THIAZOL-4-YLMETHANOL;4-(Hydroxymethyl)-1,3-thiazole;4-(Hydroxymethyl)-1,3-thiazole95%;4-(Hydroxymethyl)-1,3-thiazole 95%;4-HydroxyMethylthiazole CAS7036-04-6

CBNumber:: CB9672002

Molecular Formula:: C4H5NOS

Molecular Weight:: 115.15

MDL Number:: MFCD04115728

MOL File:: 7036-04-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:38:39

Request For Quotation

4-Hydroxymethylthiazole Properties

Melting point	112-114 °C(Solv: ethyl ether (60-29-7); ethanol (64-17-5))
Boiling point	85-90/0.5mm
Density	1.339±0.06 g/cm3(Predicted)
storage temp.	2-8°C
form	liquid
pka	13.21±0.10(Predicted)
color	colourless
InChI	InChI=1S/C4H5NOS/c6-1-4-2-7-3-5-4/h2-3,6H,1H2
InChIKey	WQVOUANKVCYEIQ-UHFFFAOYSA-N
SMILES	S1C=C(CO)N=C1
CAS DataBase Reference	7036-04-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xi
Risk Statements	37/38-41
Safety Statements	26-39
Hazard Note	Irritant
HS Code	2934100090

4-Hydroxymethylthiazole price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	280115	4-Hydroxymethylthiazole Asreported	7036-04-6	500mg	$347	2026-06-03	Buy
Usbiological	280115	4-Hydroxymethylthiazole Asreported	7036-04-6	1g	$532	2026-06-03	Buy
Usbiological	280115	4-Hydroxymethylthiazole Asreported	7036-04-6	2g	$731	2026-06-03	Buy
Usbiological	280115	4-Hydroxymethylthiazole Asreported	7036-04-6	5g	$1007	2026-06-03	Buy
Activate Scientific	AS50102	4-(Hydroxymethyl)thiazole 97%	7036-04-6	1g	$119	2026-06-04	Buy

Product number	Packaging	Price	Buy
280115	500mg	$347	Buy
280115	1g	$532	Buy
280115	2g	$731	Buy
280115	5g	$1007	Buy
AS50102	1g	$119	Buy

4-Hydroxymethylthiazole Chemical Properties,Uses,Production

Chemical Properties

Off-yellow oily liquid

Uses

4-Hydroxymethylthiazole is mainly used as a pharmaceutical intermediate.

Synthesis

14527-43-6

7036-04-6

The general procedure for the synthesis of 4-hydroxymethylthiazole from ethyl 4-thiazolecarboxylate was as follows: - Lithium aluminum hydride (1M tetrahydrofuran solution, 1.5 mL) was slowly added dropwise to a stirred tetrahydrofuran solution (4 mL) of ethyl 4-thiazolecarboxylate (224 mg) at 0 °C. - The reaction mixture was naturally warmed to room temperature with stirring for 1 hour. - Ethyl acetate (20 mL), water (1 mL), 2M sodium hydroxide solution (2 mL), and water (3 mL) were added sequentially to the reaction mixture. - The precipitate formed was removed by filtration through diatomaceous earth (iT). - The filtrate was concentrated to give 4-hydroxymethylthiazole (150 mg, 92% yield). - Nuclear magnetic resonance hydrogen spectroscopy (DMSO-d6) data: δ 4.12 (s, 2H), 7.47 (s, 1H), 9.03 (s, 1H).

References

[1] Patent: WO2005/61465, 2005, A1. Location in patent: Page/Page column 62
[2] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 367 - 391

4-Hydroxymethylthiazole synthesis

Synthesis of 4-Hydroxymethylthiazole from Thiazole-4-carboxaldehyde

4-Hydroxymethylthiazole Preparation Products And Raw materials

Raw materials

4-Thiazolemethanol,acetate(ester)(9CI) 4-Thiazolecarboxylic acid Thiazole-4-carboxaldehyde Ethyl thiazole-4-carboxylate 4-Methylthiazole

Lithium Aluminum Hydride Ethyl acetate Sodium hydroxide Tetrahydrofuran

1of2

Preparation Products

4-Hydroxymethylthiazole Suppliers

Global( 135)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Anmike Chemical Co. Ltd.	微信 18019252918 18019252918	sale@amkchem.com	China	9988	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Shanghai Litong Chemical Technology Co.,Ltd.	13598610367 0373-7129549	2468833170@qq.com	China	932	58
Shanghai Topbiochem Technology Co., Ltd	021-58170097	info@topbiochem.com	China	9513	58
Nanjing Norris-Pharm Technology Co., Ltd	13901585132	sales@norris-pharm.com	China	8869	55
Shanghai potentpharm CO.,Ltd	13524892556	sales-cn@potentpharm.com	China	1011	55

Supplier	Advantage
Shanghai Anmike Chemical Co. Ltd.	55
J & K SCIENTIFIC LTD.	76
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Pure Chemistry Scientific Inc.	62
Chemsky（shanghai）International Co.,Ltd.	50
Shanghai Litong Chemical Technology Co.,Ltd.	58
Shanghai Topbiochem Technology Co., Ltd	58
Nanjing Norris-Pharm Technology Co., Ltd	55
Shanghai potentpharm CO.,Ltd	55

4-Hydroxymethylthiazole Spectrum

4-Hydroxymethylthiazole(7036-04-6)¹HNMR

7036-04-6(4-Hydroxymethylthiazole)Related Search:

Tris(hydroxymethyl)nitromethane 2-Methyl-4-isothiazolin-3-one Thiazole methylol cellulose CARBOXYMETHYLCELLULOSE SODIUM SALT

2-Hydroxyethyl methacrylate Trimethylolpropane Tris(hydroxymethyl)aminomethane Methyl 2-amino-5-bromothiazole-4-carboxylate ETHYL 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLATE

5-Hydroxymethylthiazole ,99%,5-HYDROXYMETHYLTHIAZOLE ETHYL 2-METHYLTHIAZOLE-4-CARBOXYLATE 2-Phenyl-1,3-thiazole-4-carboxylic acid (2-Methyl-1,3-thiazol-4-yl)methanol 2-(4-Chlorophenyl)-1,3-thiazole-4-carboxylic acid

2-(3-Pyridyl)-1,3-thiazole-4-carboxylic acid 2-(4-Pyridyl)thiazole-4-carboxylic acid 2-Bromo-5-hydroxymethylthiazole

1of4

4-Hydroxymethylthiaz 4-HydroxyMethylthiazole CAS7036-04-6 4-(Hydroxymethyl)-1,3-thiazole95% THIAZOLE-4-METHANOL 1,3-THIAZOL-4-YLMETHANOL 4-HYDROXYMETHYLTHIAZOLE 4-(Hydroxymethyl)-1,3-thiazole 4-(Hydroxymethyl)-1,3-thiazole 95% 4-Thiazolemethanol 7036-04-6 4/6/7036 1875-98-3 7036-4-6 blocks Thiazoles