2-QUINOLINYLMETHANOL
- CAS No.
- 1780-17-2
- Chemical Name:
- 2-QUINOLINYLMETHANOL
- Synonyms
- QUINOLIN-2-YLMETHANOL;α-Quinaldinol;2-QUINOLINONE;2-quinolylmethanol;RARECHEM AK ML 0556;2-QUINOLINEMETHANOL;2-QUINOLINYLMETHANOL;2-Quinolineylmethanol;2-HYDROXYMETHYLQUINOLINE;4-Hydroxymethyl-2-pyrrolidinone
- CBNumber:
- CB4461872
- Molecular Formula:
- C10H9NO
- Molecular Weight:
- 159.18
- MDL Number:
- MFCD00086626
- MOL File:
- 1780-17-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Quinolinylmethanol | Q990150 | 100mg | $65 |
| 2-(Hydroxymethyl)quinoline 97% | OR23074 | 250mg | $48 |
| 2-Quinolinylmethanol | KMA0114 | 250mg | $49.5 |
| 2-(Hydroxymethyl)quinoline | 4H01-1-T3 | 250mg | $53 |
| 2-Quinolinylmethanol | KMA0114 | 1g | $123.2 |
| More product size | |||
| Melting point | 64 °C |
|---|---|
| Boiling point | 205 °C(Press: 15 Torr) |
| Density | 1.218±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 14.29±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 1780-17-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H318-H335 |
| Precautionary statements | P280-P302+P352-P305+P351+P338+P310 |
| Hazard Codes | Xi |
| Risk Statements | 20/21/22-36/37/38-41-37/38 |
| Safety Statements | 26-36/37/39-39 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 2933491090 |
2-QUINOLINYLMETHANOL price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | Q990150 | 2-Quinolinylmethanol | 1780-17-2 | 100mg | $65 | 2021-12-16 | Buy |
| Apolloscientific | OR23074 | 2-(Hydroxymethyl)quinoline 97% | 1780-17-2 | 250mg | $48 | 2021-12-16 | Buy |
| AK Scientific | KMA0114 | 2-Quinolinylmethanol | 1780-17-2 | 250mg | $49.5 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H01-1-T3 | 2-(Hydroxymethyl)quinoline | 1780-17-2 | 250mg | $53 | 2021-12-16 | Buy |
| AK Scientific | KMA0114 | 2-Quinolinylmethanol | 1780-17-2 | 1g | $123.2 | 2021-12-16 | Buy |
2-QUINOLINYLMETHANOL Chemical Properties,Uses,Production
Uses
Intermediate in the preparation of aminopiperidines and related compounds as MCH receptor modulators useful in the treatment of metabolic, feeding and sexual disorders in humans.
Synthesis
19575-07-6
1780-17-2
General procedure for the synthesis of 2-hydroxymethylquinoline from methyl quinoline-2-carboxylate: a tetrahydrofuran (THF, 30 mL) solution of methyl quinoline-2-carboxylate (5 g, 26.8 mmol) was slowly added to a tetrahydrofuran (THF, 20 mL) solution containing sodium borohydride (NaBH4, 710 mg, 18.8 mmol) at room temperature. The reaction mixture was stirred at 35 °C for 30 min. Subsequently, methanol (2.5 mL), warm water (30 mL) and ethyl acetate (20 mL) were added sequentially at the same temperature. The organic layer was separated and washed with deionized water (2 x 30 mL). The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/methylcyclohexane=60/40) to give a white solid product in 73% yield. The melting point of the product was 135 °C (decomposition). Nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3) showed: δ 4.68 (1H, s, OH), 4.95 (2H, s, CH2), 7.31 (1H, m, aromatic CH), 7.55 (1H, m, aromatic CH), 7.71 (1H, m, aromatic CH), 7.81 (1H, m, aromatic CH), 8.10 (2H , m, aromatic CH). The nuclear magnetic resonance carbon spectrum (13C NMR, 75 MHz, CDCl3) showed: δ 64.25, 118.43, 126.35, 127.55, 127.69, 128.57, 129.81, 136.86, 146.72, 159.19. Calculated values for elemental analysis (C10H9NO): C, 75.45; H, 5.70 Measured values (C10H9NO): C, 75.45; H, 5.70; N, 8.80; measured values: C, 75.13; H, 5.56; N, 8.75.
References
[1] Organic Letters, 2005, vol. 7, # 17, p. 3609 - 3612
[2] Tetrahedron Letters, 2012, vol. 53, # 35, p. 4747 - 4750
[3] Tetrahedron, 2013, vol. 69, # 44, p. 9322 - 9328
[4] Tetrahedron Asymmetry, 2009, vol. 20, # 14, p. 1672 - 1682
[5] Journal of Organic Chemistry, 1953, vol. 18, p. 55,56
2-QUINOLINYLMETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Nanjing jinheyou Trading Co., Ltd. | 15705188088 | admin@jheyou.com | CHINA | 1268 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9983 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
View Lastest Price from 2-QUINOLINYLMETHANOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-31 | 2-QUINOLINYLMETHANOL
1780-17-2
|
US $6.60 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co | |
 |
2019-12-20 | 2-QUINOLINYLMETHANOL
1780-17-2
|
US $0.00 / g | 1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. |
-
- 2-QUINOLINYLMETHANOL
1780-17-2
- US $6.60 / KG
- 97%-99%
- Career Henan Chemical Co
-
- 2-QUINOLINYLMETHANOL
1780-17-2
- US $0.00 / g
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
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