ChemicalBook >> CAS DataBase List >>MIK665
MIK665
- CAS No.
- 1799631-75-6
- Chemical Name:
- MIK665
- Synonyms
- S64315;MIK665;MIK665,S64315;S64315 (MIK665);MIK665, 10 mM in DMSO;S64315 (MIK665) ，S8836;S64315(MIK665 ，S-64315);MIK665 (S-64315, MIK-665);(2S)-2-(5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yloxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid;(αR)-α-[[(5S)-5-[3-Chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[2-(2-methoxyphenyl)-4-pyrimidinyl]methoxy]benzenepropanoic acid
- CBNumber:
- CB44635293
- Molecular Formula:
- C47H44ClFN6O6S
- Molecular Weight:
- 875.41
- MDL Number:
- MOL File:
- 1799631-75-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-14 16:49:18
| Boiling point | 909.4±65.0 °C(Predicted) |
|---|---|
| Density | 1.324±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble |
| form | A solid |
| pka | 2.53±0.11(Predicted) |
| color | White to off-white |
| InChIKey | PKYIMGFMRFVOMB-UHFFFAOYSA-N |
| SMILES | O(C1N=CN=C2SC(C3C=CC(F)=CC=3)=C(C3C=CC(OCCN4CCN(C)CC4)=C(Cl)C=3C)C=12)C(C(=O)O)CC1C=CC=CC=1OCC1C=CN=C(C2C=CC=CC=2OC)N=1 |
| FDA UNII | 801XYWHNOS |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
MIK665 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 36404 | MIK665 ≥98% | 1799631-75-6 | 1mg | $185 | 2026-04-30 | Buy |
| Cayman Chemical | 36404 | MIK665 ≥98% | 1799631-75-6 | 5mg | $599 | 2026-04-30 | Buy |
| Cayman Chemical | 36404 | MIK665 ≥98% | 1799631-75-6 | 10mg | $1105 | 2026-04-30 | Buy |
| Biosynth | BM170717 | MIK665 | 1799631-75-6 | 1mg | $356.95 | 2026-06-04 | Buy |
| Biosynth | BM170717 | MIK665 | 1799631-75-6 | 2mg | $571.12 | 2026-06-04 | Buy |
MIK665 Chemical Properties, Uses, Production
Uses
MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor[1]. MIK665 has an IC50 of 1.81 nM for MCL1[2].
IC 50
Mcl-1: 1.81 nM (IC50)
References
[1] Mukherjee N, et al. Simultaneously Inhibiting BCL2 and MCL1 Is a Therapeutic Option for Patients with Advanced Melanoma. Cancers (Basel). 2020;12(8):2182. Published 2020 Aug 5. DOI:10.3390/cancers12082182
[2] Zoltán SZLáVIK, et al. New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them. WO2016207225A1.
MIK665 Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 81)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SuZhou GoodChemTech Co., Ltd | 18136139868; 18136139868 | jinlun@goodchemtech.cn | China | 321 | 58 |
| Elucigen bio | 13501719342 13501719342 | wayne.zheng@elucigenbio.com | China | 5000 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai YuanQi Biotechnology Co., Ltd. | +86-2332782371 +86-18120098618 | sales@adobechem.com | China | 1250 | 50 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4858 | 55 | |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
MIK665
MIK665,S64315
S64315 (MIK665)
(2S)-2-(5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yloxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid
MIK665 (S-64315, MIK-665)
Benzenepropanoic acid, α-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[2-(2-methoxyphenyl)-4-pyrimidinyl]methoxy]-, (αR)-
(5S)-(R)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid
S64315(MIK665 ，S-64315)
(αR)-α-[[(5S)-5-[3-Chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[2-(2-methoxyphenyl)-4-pyrimidinyl]methoxy]benzenepropanoic acid
MIK665, 10 mM in DMSO
S64315 (MIK665) ，S8836
S64315
1799631-75-6
C47H44ClFN6O6S
