ChemicalBook >> CAS DataBase List >>CP-944629
CP-944629
- CAS No.
- 668990-94-1
- Chemical Name:
- CP-944629
- Synonyms
- CP-944629;CP-944629 >=98% (HPLC);1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethyl)-6-[4-(2,4,5-trifluorophenyl)-5-oxazolyl]-
- CBNumber:
- CB44741671
- Molecular Formula:
- C19H15F3N4O
- Molecular Weight:
- 372.34
- MDL Number:
- MOL File:
- 668990-94-1.mol
- MSDS File:
- SDS
Last updated:2026-05-22 09:14:11
| Density | 1.39±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | room temp |
| solubility | DMSO: 10mg/mL, clear |
| form | powder |
| pka | 2.70±0.50(Predicted) |
| color | white to beige |
| InChI | 1S/C19H15F3N4O/c1-19(2,3)18-25-24-15-5-4-10(8-26(15)18)17-16(23-9-27-17)11-6-13(21)14(22)7-12(11)20/h4-9H,1-3H3 |
| InChIKey | VNZJNPIWZYMGAO-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=NN=C2C=CC(C3=C(C4=C(F)C=C(F)C(F)=C4)N=CO3)=CN21 |
| FDA UNII | KB2ZD36HED |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
CP-944629 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0238 | CP-944629 ≥98% (HPLC) | 668990-94-1 | 5mg | $114 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0238 | CP-944629 ≥98% (HPLC) | 668990-94-1 | 25mg | $434 | 2023-06-20 | Buy |
| Biosynth | TBB99094 | CP-944629 | 668990-94-1 | 25mg | $853.75 | 2026-06-05 | Buy |
| Biosynth | TBB99094 | CP-944629 | 668990-94-1 | 50mg | $1365.5 | 2026-06-05 | Buy |
| Biosynth | TBB99094 | CP-944629 | 668990-94-1 | 100mg | $1899 | 2026-06-05 | Buy |
CP-944629 Chemical Properties, Uses, Production
Biochem/physiol Actions
CP-9446219 is a potent p38alpha (p38α) inhibitor (IC50 = 1.8 nM) with no inhibitory potency against a panel of 26 other knases (IC50 >10 μM), including p38gamma (p38γ) and p38delta (p38δ), MKK1, MAPK2/ERK2, JNK, MAPKAP-K1a, and MAPKAP-K2. CP-944629 effectively inhibits LPS-stimulated cellular TNF-α production in vitro (IC50 = 63 and 8.3 nM, using human whole blood and isolated mononuclear cells, respectively) and in rats in vivo (ED50 = 0.1 mg/kg p.o.) with good pharmacokinetic profile and oral availability (F = 66%/monkey, 54%/rat).
CP-944629 Preparation Products And Raw materials
Raw materials
Preparation Products
CP-944629 Suppliers
Global Suppliers ( 11)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Afflon Pharmaceutical (Sichuan) Co., Ltd. | 17336178085 | 1684779048@qq.com | China | 2263 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |
| TargetMol Chemicals Inc. | 58 |
| Energy Chemical | 58 |
| Beijing Biocreative Technology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Afflon Pharmaceutical (Sichuan) Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
CP-944629
1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethyl)-6-[4-(2,4,5-trifluorophenyl)-5-oxazolyl]-
CP-944629 >=98% (HPLC)
668990-94-1
