Product Details
| Product Name:
ML382 |
CAS No.:
1646499-97-9 |
| Purity:
99.79% |
Supply Ability:
10g |
| Release date:
2026/05/26 |
Product Introduction
Bioactivity
| Name | ML382 |
| Description | ML382 is a potent and selective MrgX1 positive allosteric modulator (EC50 : 190 nM). |
| In vivo | ML382 enhances the ability of BAM8-22 to inhibit high-voltage-activated Ca2+ channels and attenuate spinal nociceptive transmission, both BAM8-22 and ML382 effectively attenuated evoked, persistent, and spontaneous pain without causing obvious side effects.?Notably, ML382 by itself attenuated both evoked pain hypersensitivity and spontaneous pain in MrgprX1 mice after nerve injury without acquiring coadministration of an exogenous agonist[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.55 mM), Sonication is recommended.
DMSO : 32.5 mg/mL (90.17 mM), Sonication is recommended.
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| Keywords | pain | nociceptor | neurons | nervous | MrgX1 | ML-382 | ML382 | ML 382 | injury | Inhibitor | inhibit | DRG |
| Inhibitors Related | (R)-ZINC-3573 | MRGPRX1 agonist 1 | MrgprX2 antagonist-3 | BAM (8-22) acetate | MrgprX2 antagonist-8 | MrgprX2 antagonist-1 | MrgprX2-IN-1 | Imidazolidinyl urea | PAMP-12(human, porcine) TFA | Imidazolidinyl urea (Standard) | Mrgx2 antagonist-3 | MRGPRX4 modulator-2 |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States