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MAST CELL DEGRANULATING PEPTIDE

MAST CELL DEGRANULATING PEPTIDE Structure
MAST CELL DEGRANULATING PEPTIDE structure
CAS No.
32908-73-9
Chemical Name:
MAST CELL DEGRANULATING PEPTIDE
Synonyms
MCD;isulfide);MCD PEPTIDE;Peptide 401;IKCNCKRHVIKPHICRKICGKN-NH2;MCD PEPTIDE (APIS MELLIFERA);MAST CELL DEGRANULATING PEPTIDE;MAST CELL DEGRANULATING (MCD) PEPTIDE;mastcelldegranulatingpeptide(honeybee);MCD-PEPTIDE (HONEYBEE, APIS MELLIFERA)
CBNumber:
CB4493264
Molecular Formula:
C110H192N40O24S4
Molecular Weight:
2587.24
MDL Number:
MFCD00167557
MOL File:
32908-73-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:11
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MAST CELL DEGRANULATING PEPTIDE Properties

Density 1.50±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility Soluble in DMSO
form Solid
color White to off-white
Sequence Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)

SAFETY

Risk and Safety Statements

WGK Germany  3
RTECS  OQ5980000

MAST CELL DEGRANULATING PEPTIDE price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth PMC-4258-V MCD-Peptide 32908-73-9 0.5mg $1133.96 2026-06-04 Buy
Biosynth FM110262 Mast Cell Degranulating (MCD) Peptide 32908-73-9 500ug $1170 2026-06-04 Buy
Biosynth FM110262 Mast Cell Degranulating (MCD) Peptide 32908-73-9 2000ug $3640 2026-06-04 Buy
ChemScene CS-7079 Peptide 401 97.37% 32908-73-9 1mg $101 2026-06-04 Buy
ChemScene CS-7079 Peptide 401 97.37% 32908-73-9 5mg $341 2026-06-04 Buy
Product number Packaging Price Buy
PMC-4258-V 0.5mg $1133.96 Buy
FM110262 500ug $1170 Buy
FM110262 2000ug $3640 Buy
CS-7079 1mg $101 Buy
CS-7079 5mg $341 Buy

MAST CELL DEGRANULATING PEPTIDE Chemical Properties, Uses, Production

Uses

Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

Biological Activity

Peptide 401 is a potent mast cell degranulation peptide derived from bee venom that inhibits vascular permeability.

in vivo

Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED 50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased 125 I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins). Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, ie, hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcut aneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5-hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents.

target

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IC 50

serotonin; Histamine Receptor

References

[1] Hanson JM, et al. Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.). Br J Pharmacol. 1974 Mar;50(3):383-92. DOI:10.1111/j.1476-5381.1974.tb09613.x
[2] Banks BE, et al. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) andcompound 48/80 results from mast cell degranulation in vivo. Br J Pharmacol. 1990 Feb;99(2):350-4. DOI:10.1111/j.1476-5381.1990.tb14707.x

MAST CELL DEGRANULATING PEPTIDE Preparation Products And Raw materials

Raw materials

Preparation Products

MAST CELL DEGRANULATING PEPTIDE Suppliers

Global Suppliers ( 75)

serotonin

Histamine Receptor

Supplier Tel Email Country ProdList Advantage
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Cellmano Biotech Limited 0551-65326643 18156095617 info@cellmano.com China 1010 55
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Creative Peptides info@creative-peptides.com United States 6083 56
Shanghai Xilong Biochemical Technology Co., Ltd. 021-52907766-8042 China 9928 58
Nanjing Leon Biological Technology Co., Ltd. 025-84523390 -127; 17705183659 sales@njleonbiotech.com China 5501 55
Nanjing Peptide Biotech Ltd. 025-58361106-805 15951641583 zhao.xu@njpeptide.com China 9976 55
Chengdu Youngshe Chemical Co., Ltd. +86-17380623303 Caroline@youngshechem.com China 4726 58
Supplier Advantage
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60
Cellmano Biotech Limited 55
MedChemexpress LLC 58
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Creative Peptides 56
Shanghai Xilong Biochemical Technology Co., Ltd. 58
Nanjing Leon Biological Technology Co., Ltd. 55
Nanjing Peptide Biotech Ltd. 55
Chengdu Youngshe Chemical Co., Ltd. 58

View Latest Price from MAST CELL DEGRANULATING PEPTIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MAST CELL DEGRANULATING PEPTIDE pictures 2024-08-13 MAST CELL DEGRANULATING PEPTIDE
32908-73-9
 $1.00 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
MAST CELL DEGRANULATING PEPTIDE pictures 2020-02-17 MAST CELL DEGRANULATING PEPTIDE
32908-73-9
 $7.00 1KG 99% 100KG Career Henan Chemical Co

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MAST CELL DEGRANULATING PEPTIDE Cys-Gly MAST CELL DEGRANULATING PEPTIDE

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H-ILE-LYS-+CYS-ASN-++CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-+CYS-ARG-LYS- ILE-++CYS-GLY-LYS-ASN-NH2 H-ILE-LYS-CYS-ASN-CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-CYS-ARG-LYS-ILE-CYS-GLY-LYS-ASN-NH2 H-ILE-LYS-CYS-ASN-CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-CYS-ARG-LYS-ILE-CYS-GLY-LYS-ASN-NH2 (RANDOM CYCLIZATION) IKCNCKRHVIKPHICRKICGKN-NH2 ILE-LYS-CYS-ASN-CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-CYS-ARG-LYS-ILE-CYS-GLY-LYS-ASN-NH2 MAST CELL DEGRANULATING PEPTIDE MAST CELL DEGRANULATING PEPTIDE (APIS MELLIFERA) MAST CELL DEGRANULATING (MCD) PEPTIDE MCD PEPTIDE MCD PEPTIDE (APIS MELLIFERA) isulfide) mastcelldegranulatingpeptide(honeybee) mastcelldegranulatingpeptide(honeybeereduced)cyclic(3-15),(5-19)-bis(d MCD-PEPTIDE (HONEYBEE, APIS MELLIFERA) L-Ile-L-Lys-L-Cys(1)-L-Asn-L-Cys(2)-L-Lys-L-Arg-L-His-L-Val-L-Ile-L-Lys-L-Pro-L-His-L-Ile-L-Cys(1)-L-Arg-L-Lys-L-Ile-L-Cys(2)-Gly-L-Lys-L-Asn-NH2 Peptide 401 Mast Cell Degranulating (MCD) Peptide Peptide 401 L-Aspartamide, L-isoleucyl-L-lysyl-L-cysteinyl-L-asparaginyl-L-cysteinyl-L-lysyl-L-arginyl-L-histidyl-L-valyl-L-isoleucyl-L-lysyl-L-prolyl-L-histidyl-L-isoleucyl-L-cysteinyl-L-arginyl-L-lysyl-L-isoleucyl-L-cysteinylglycyl-L-lysyl-, cyclic (3→15),(5→19)-bis(disulfide) MCD 32908-73-9 C110H192N40O24S4 Voltage-gated Ion Channels Ion Channels Potassium Channel Modulators Monovalent Ion Channels BioChemical Cell Signaling and Neuroscience Cell Biology