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Manidipine

Manidipine Structure
Manidipine structure
CAS No.
89226-50-6
Chemical Name:
Manidipine
Synonyms
Manidipine (Manyper);Artedil;Iperten;Manidipine;Franidipine;Manidipine 6300;Manidipine（base）;Manidipine(CV-4093);Manidipine Impurity1254;Manidipine (10mM in DMSO)
CBNumber:
CB4506757
Molecular Formula:
C35H38N4O6
Molecular Weight:
610.7
MDL Number:
MFCD00871291
MOL File:
89226-50-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
Product description Number Pack Size Price
Manidipine ≥98% 23614 10mg $121
Manidipine ≥98% 23614 25mg $227
Manidipine ≥98% 23614 50mg $388
Manidipine TRC-M164000-5MG 5mg $107
Manidipine TRC-M164000-50MG 50mg $485
More product size
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Manidipine Properties

Melting point 125-128°C
Boiling point 722.0±60.0 °C(Predicted)
Density 1.232±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Soluble in DMSO > 10 mM
form Powder
pka 6.12±0.10(Predicted)
color Light yellow to yellow
LogP 4.135
FDA UNII 6O4754US88

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
REACH Registrations Active
NFPA 704
0
2 0

Manidipine price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23614 Manidipine ≥98% 89226-50-6 10mg $121 2026-04-30 Buy
Cayman Chemical 23614 Manidipine ≥98% 89226-50-6 25mg $227 2026-04-30 Buy
Cayman Chemical 23614 Manidipine ≥98% 89226-50-6 50mg $388 2026-04-30 Buy
TRC TRC-M164000-5MG Manidipine 89226-50-6 5mg $107 2026-06-03 Buy
TRC TRC-M164000-50MG Manidipine 89226-50-6 50mg $485 2026-06-03 Buy
Product number Packaging Price Buy
23614 10mg $121 Buy
23614 25mg $227 Buy
23614 50mg $388 Buy
TRC-M164000-5MG 5mg $107 Buy
TRC-M164000-50MG 50mg $485 Buy

Manidipine Chemical Properties,Uses,Production

Description

Manidipine is a dihydropyridine L- and T-type calcium channel blocker. It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; ) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively). In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol when administered at a dose of 3 mg/kg. Formulations containing manidipine have been used in the treatment of hypertension.

Chemical Properties

Light Yellow Crystalline Solid

Uses

Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

Definition

ChEBI: Manidipine is a diarylmethane.

Synthesis

Manidipine hydrochloride

89226-75-5

Manidipine

89226-50-6

Synthesis of 3-(2-(4-diphenylmethylpiperazin-1-yl)ethyl)-5-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride as 3-(2-(4-diphenylmethylpiperazin-1-yl)ethyl)-5-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3 ,5-dicarboxylate in the following general steps: 1. 12 g of sodium hydroxide was weighed and 18 mL of water was added to prepare a 40% aqueous sodium hydroxide solution and cooled in an ice bath. 2. add manidipine hydrochloride (20.5 g) to a 500 mL three-necked flask pre-cooled in an ice bath with 100 mL of water. 3. With stirring on, slowly add the pre-prepared ice-cold 40% sodium hydroxide solution dropwise to the three-necked flask. 4. During the dropwise addition, 90mL of ethyl acetate was added. 5. After all bases are added, stop stirring and let stand for stratification. 6. After determining the pH of the aqueous phase to be 11-12, the liquid phase was separated. 7. The aqueous phase was extracted twice with ethyl acetate (30mL x 2) and the organic phases were combined. 8. The combined organic phases were washed once with water (50mL) and once with saturated sodium chloride solution (50mL). 9. The organic phase was dried with anhydrous sodium sulfate (15 g) for 2 hours. 10. After filtration, about 35 parts of the solvent were removed by evaporation under reduced pressure to give a yellow solid manidipine free base in 98% yield.

References

[1] Patent: CN105439942, 2016, A. Location in patent: Paragraph 0040; 0041; 0042

Manidipine synthesis

841-77-0
89226-50-6
Synthesis of Manidipine from 1-BENZHYDRYLPIPERAZINE

Manidipine Preparation Products And Raw materials

Raw materials

Manidipine Acetyl ketene Methyl 3-aminocrotonate Manidipine hydrochloride 1-(2-Hydroxyethyl)piperazine
Diisopropyl ether Magnesium sulfate 2-(4-Benzhydrylpiperazino)ethyl acetoacetate 5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid 2-(4-benzhydrylpiperazin-1-yl)ethanol
Methyl 3-nitrobenzylideneacetoacetate 3-Nitrobenzaldehyde 1-BENZHYDRYLPIPERAZINE

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Preparation Products

Manidipine Suppliers

Global( 149)Suppliers
Supplier Tel Email Country ProdList Advantage
Moxin Chemicals 		+86-17320513646 +86-17320513646 anna@molcoo.com China 9998 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63645 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17339 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-17392587031 1059@dideu.com China 9984 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9040 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +86-18949823763 sales@tnjchem.com China 25333 58
Supplier Advantage
Moxin Chemicals 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
SIMAGCHEM CORP 		58
TargetMol Chemicals Inc. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Baoji Guokang Healthchem Co., Ltd. 		58
InvivoChem 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from Manidipine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Manidipine pictures 2026-07-15 Manidipine
89226-50-6
 $30.00-72.00 99.30% 10g TargetMol Chemicals Inc.
Manidipine Impurity pictures 2025-12-16 Manidipine Impurity
89226-50-6
 10mg 98 10000000 Moxin Chemicals
Manidipine pictures 2021-07-13 Manidipine
89226-50-6
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
  • Manidipine pictures
  • Manidipine
    89226-50-6
  • $30.00-72.00
  • 99.30%
  • TargetMol Chemicals Inc.
  • Manidipine pictures
  • Manidipine
    89226-50-6
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Manidipine Spectrum

Manidipine(89226-50-6)1HNMR

89226-50-6(Manidipine)Related Search:

Dimethyl sulfide Manidipine hydrochloride Nifedipine Dichlorodiphenylsilane Nimodipine
1,5-Diphenylcarbazide 1,3-Diphenyl-2-thiourea Amlodipine 3,4'-DIAMINODIPHENYLMETHANE Dimethyl fumarate
Dimethyl ether Chlorodiphenylphosphine Dimethyl phthalate Diphenyldimethoxysilane ETHANE
Dimethyl sulfoxide N,N-Dimethylformamide Methyl

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Manidipine(CV-4093) MANIDIPINE;CV-4093;FRANIDIPINE;(±)-MANIDIPINE 2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(diphenylmethyl)-1-piperazinyl)ethyl methyl ester 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine 3-{2-[4-(diphenylMethyl)piperazin-1-yl]ethyl} 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester MANIDIPINE: MANIDIPINE DIHYDROCHLORIDE 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester (9CI) Franidipine Manidipine 6300 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] ester 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 5-methyl 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] ester 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)piperazin-1-yl]ethyl]5-methyl ester 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridi 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester Manidipine（base） 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl]5-methyl ester Manidipine 2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Artedil Iperten 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester Manidipine (10mM in DMSO) Manidipine Impurity1254 Calcium Channel,Manidipine,Inhibitor,inhibit,Ca channels,Ca2+ channels Manidipine (Manyper) 89226-50-6 120096-68-4 Inhibitors Artedil, Iperten Dihydropyridine Dihydropyridine Class Chemicals Intermediates & Fine Chemicals Pharmaceuticals