Manidipine synthesis
- Product Name:Manidipine
- CAS Number:89226-50-6
- Molecular formula:C35H38N4O6
- Molecular Weight:610.7
89226-75-5
89226-50-6
Synthesis of 3-(2-(4-diphenylmethylpiperazin-1-yl)ethyl)-5-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride as 3-(2-(4-diphenylmethylpiperazin-1-yl)ethyl)-5-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3 ,5-dicarboxylate in the following general steps: 1. 12 g of sodium hydroxide was weighed and 18 mL of water was added to prepare a 40% aqueous sodium hydroxide solution and cooled in an ice bath. 2. add manidipine hydrochloride (20.5 g) to a 500 mL three-necked flask pre-cooled in an ice bath with 100 mL of water. 3. With stirring on, slowly add the pre-prepared ice-cold 40% sodium hydroxide solution dropwise to the three-necked flask. 4. During the dropwise addition, 90mL of ethyl acetate was added. 5. After all bases are added, stop stirring and let stand for stratification. 6. After determining the pH of the aqueous phase to be 11-12, the liquid phase was separated. 7. The aqueous phase was extracted twice with ethyl acetate (30mL x 2) and the organic phases were combined. 8. The combined organic phases were washed once with water (50mL) and once with saturated sodium chloride solution (50mL). 9. The organic phase was dried with anhydrous sodium sulfate (15 g) for 2 hours. 10. After filtration, about 35 parts of the solvent were removed by evaporation under reduced pressure to give a yellow solid manidipine free base in 98% yield.
841-77-0
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89226-50-6
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Yield:-
Steps:
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide; toluene / 20 °C / Reflux
2: dmap; dicyclohexyl-carbodiimide / toluene / 2 h / 20 - 75 °C
References:
CIPLA LIMITED;RAO, Dharmaraj Ramachandra;KANKAN, Rajendra Narayanrao;GHAGARE, Maruti Ganpati;CURTIS, Philip Anthony WO2011/23954, 2011, A2
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89226-50-6
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130 suppliers
$49.00/5mg